Aerosol penetration and leakage characteristics of masks used in the health care industry.

BACKGROUND: Historically, surgical masks have been worn to protect patients from being infected by large, pathogen-containing aerosol droplets emitted by health care personnel. Today, emphasis has shifted from solely protecting the patient to protecting the health care worker as well. As a result of new procedures used in operating rooms and clinical areas, aerosolized hazardous agents in the submicrometer size range are being produced, posing a potential threat to health care workers. METHODS: Eight surgical masks were tested for aerosol particle penetration through their filter media and through induced face-seal leaks. RESULTS: The percentage of filter penetration ranged from 20% to nearly 100% for submicrometer-sized particles. In comparison, a dust-mist-fume respirator used in industrial settings had significantly less penetration through its filter medium. When the surgical masks had artificially induced face-seal leaks, the concentration of submicrometer-sized particles inside the mask increased slightly; in contrast, the more protective dust-mist-fume respirator showed a fourfold increase in aerosol penetration into the mask with an artificial leak 4 mm in diameter. CONCLUSION: We conclude that the protection provided by surgical masks may be insufficient in environments containing potentially hazardous submicrometer-sized aerosols.

Equivalent diameter of standard quartz dust used as a test aerosol for the dust respirator.

In the standard of the approval test for dust respirator certification, test aerosols are defined as air containing quartz particles of 2 microns or smaller1. However, it is well-known that the filtration efficiency of air filters depends on the size of the test aerosol particles. Alternative test aerosols containing submicron size particles will be studied for use in future approval test of dust respirators. Before searching for alternatives, characterization of currently-used quartz dust, e.g. information about size and electrostatic charge of the aerosol particles, should be determined. The currently-used approval test measures filtration efficiencies with a light scattering photometer. The photometer gives overall aerosol concentration, while Aerodynamic Particle Sizer (APS-33B, TSI Inc., St. Paul, U.S.A.) is able to give the number concentration for each particle size based on the aerodynamic diameter ranging from 0.9 to 2.0 microns. In this study, equivalent diameter was defined as the diameter at which penetration has the same value when measured by APS-33B and by light scattering photometer. The equivalent diameter for the ten filter samples for dust respirator was around 1 microns, irrespective of neutralization of the test aerosol.

Comparative study of challenge aerosols for performance test for dust respirators.

A comparative study of challenge aerosols was conducted to review a performance test for dust respirators. The national approval test for dust respirator certification in Japan requires that air containing quartz particles of smaller than 2 microns in diameter should be used as the test aerosol. Aerosols with broad size distributions may therefore be used as the test aerosols. In view of the international harmonization of respirator certification standards, it is necessary to use alternative test aerosols for the approval test for dust respirators. The present study was undertaken to measure the collection efficiency of filters by using three kinds of test aerosols, i.e., quartz dust, sodium chloride and dioctyl sebacate mist aerosols. We used the cartridges of dust respirators and filtering facepieces from eight Japanese and foreign manufacturers, all of which have been certified by the national approval test. Good correlation among the measured collection efficiencies was found for the three test aerosols, but penetrations with sodium chloride and dioctyl sebacate mist aerosols were more than 10 times those of quartz dust aerosol.

Estimation of fibrous aerosol deposition in upper bronchi based on experimental data with model bifurcation.

Lung deposition of fibrous aerosol was studied by using a model of the lung bifurcation with dimensions based on the symmetric model A of Weibel. The fibrous aerosols were introduced to the model under steady inspiratory flow conditions. Glass fibers depositing in the daughter tubes and these escaping from them were observed under a scanning electron microscope (SEM). The deposited fractions were calculated for each length and diameter using a bivariate lognormal distribution. In this study the authors propose empirical equations to estimate total deposited fractions of fibrous aerosol at upper bronchi. The dimensionless relationship among deposited fractions Fd, Stokes number St for randomly-oriented fibers and interception parameter I were used to estimate the deposited fraction at arbitrary position in the upper bronchi. The calculation procedure for Fd(St,I) consists of two steps: the determination of the four deposited fractions, Fdn for each In (n=1-4) followed by interpolation or extrapolation from Fdn to find the deposited fraction Fd at a given I. With this procedure, it is possible to determine the deposited fraction Fd in the range of 2 x 10(-3)

Cell toxicity, hemolytic action and clastogenic activity of asbestos and its substitutes.

The cell toxicity, hemolytic and clastogenic activity were examined in various kinds of asbestos and some asbestos substitutes with reference to the their mineralogical and physicochemical characteristics. There were thirty-five fibrous and non-fibrous samples including UICC chrysotile, size-selected samples of UICC chrysotile, chrysotile altered by heating and grinding, Yamabe (Japan) chrysotile with long and short fibers, Coalinga (U.S. A.) chrysotile with short fibers, UICC crocidolite, amosite, and 19 non-asbestos samples such as, glass fibers, calcium silicates, sepiolites and some clay minerals. The cell toxicity and the hemolytic and clastogenic activity of asbestos were the strongest for chrysotile among all of the asbestos samples tested, and their strengths varied with fiber length and with the conditions of grinding and heating. These cellular effects of Yamabe chrysotile with long fibers and size-selected UICC chrysotile with long fibers were stronger than those of chrysotile of the same origin but with short fibers. These effects were weaker in chrysotile altered by heating and grinding. Among the asbestos substitutes, the cell toxicity, hemolytic and clastogenic activities of thin glass fibers were more marked than those of thick glass fibers. The four types of sepiolite were strongly hemolytic, but their cell toxicity and clastogenicity varied according to their grade of crystallinity and/or fiber size. These effects of calcium silicates and some clay minerals were generally low but varied with mineral species. In general, the cell toxicity, hemolytic and clastogenic activities of the asbestos substitutes tested here were mild compared with those of asbestos.

Breathing pattern simulation using slit/cam valve.

A breathing simulator was developed to reproduce the human breathing pattern. The simulator incorporated a newly designed slit/cam valve without piston/cylinder or bellows. This breathing simulator was able to separate airflow into expiration and inspiration without check valves. The separation of flow facilitated easy and precise measurements of the aerosol or gas concentrations in performance tests of respirator filters, exhalation valves, and whole respirators under cyclic flow conditions. The programmed motions of the single cam of the slit/cam valve produced all the patterns of sedentary, 208, 415, and 622 kg.m/min work rates presented in other research because the stepping motor driving the cam was controlled by microcomputer and the breathing patterns were stored in the computer memory. The breathing patterns generated by this simulator were smooth curves and reproduced the original curves very precisely. The breathing simulator is very small and can be utilized for testing protective equipment.

Fit test for filtering facepieces: search for a low-cost, quantitative method.

Conventional fit-testing methods use HEPA filter cartridges to distinguish face-seal leakage from filter penetration and thereby test a respirator's ability to face-seal. These methods cannot be applied to low-efficiency filtering facepieces that also protect the wearer through aerosol particle retention by the filter material. Therefore, the ability of a filtering facepiece to face-seal is of interest to the developer for improving the design and to the user for finding the conditions for optimal face-seal. A unique difference has been found between the combined aerosol penetration through filter medium and leak site at low versus high flow rate. This feature has been used to differentiate face-seal leakage from filter penetration. A "fit index" has been introduced as the most sensitive indicator of fit. When normalized by reference to the aerosol penetration through the filter material, this index displays a unified behavior irrespective of the filter material used. The fit index is determined by relating the measured total aerosol concentration at a high flow rate to that at a low flow rate. Tests during normal breathing of a human subject compare well with the data obtained during breath-holding experiments. Available instruments may be used for this test, but need to be modified for tests on humans.

Variation in quantitative respirator fit factors due to fluctuations in leak size during fit testing.

Variation in fit factors during quantitative respirator fit testing was studied for a high degree of fit (aerosol fit factors > 1000) and a low degree of fit (aerosol fit factors < 1000). In a controlled human study, fit factors were determined sequentially for three different exercises by (1) an aerosol fit test (using a portable condensation nuclei counter and room aerosol as the test agent) and (2) the newly developed dichotomous-flow fit test (Dichot). For the higher level of respirator fit, the aerosol fit factors were 30 to 60 times the corresponding flow fit factors, and for the lower level of respirator fit they were 2 to 4 times the flow fit factors. A coefficient of variation (CV) of 84% (GSD 1.6) for the higher respirator fit and 178% (GSD 2.2) for the lower respirator fit data was observed in the human study when aerosol fit factors for the three exercises were pooled. In a similar mannequin study, the center sampling probe gave aerosol fit factors with a CV of 5.4% (GSD 1.05). The flow fit factors for all three exercises pooled had a CV of 36% (GSD 1.3) for the higher respirator fit and 40% (GSD 1.5) for the lower respirator fit data, while the mannequin study gave flow fit factors with a CV of 2.2% (GSD 1.02). Thus, the variation in fit factors obtained in the human study was much higher than that obtained in a mannequin study. However, the variation in the aerosol method relative to the flow method, in the human study, os of the same order of magnitude as in the mannequin study.(ABSTRACT TRUNCATED AT 250 WORDS)