Detalhe da pesquisa
1.
Accelerating therapeutics development during a pandemic: population pharmacokinetics of the long-acting antibody combination AZD7442 (tixagevimab/cilgavimab) in the prophylaxis and treatment of COVID-19.
Antimicrob Agents Chemother
; 68(5): e0158723, 2024 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38534112
2.
Common UGT1A9 polymorphisms do not have a clinically meaningful impact on the apparent oral clearance of dapagliflozin in type 2 diabetes mellitus.
Br J Clin Pharmacol
; 88(4): 1942-1946, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34687551
3.
Population Pharmacodynamic Dose-Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate.
Clin Pharmacokinet
; 63(4): 551-560, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38504082
4.
Potassium homeostasis and therapeutic intervention with sodium zirconium cyclosilicate: A model-informed drug development case study.
CPT Pharmacometrics Syst Pharmacol
; 13(2): 296-307, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38050337
5.
Randomised, blinded, cross-over evaluation of the palatability of and preference for different potassium binders in participants with chronic hyperkalaemia in the USA, Canada and Europe: the APPETIZE study.
BMJ Open
; 14(2): e074954, 2024 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38387989
6.
A Phase 1, open-label, crossover study evaluating the effect of a single dose of sodium zirconium cyclosilicate on the pharmacokinetics of tacrolimus and cyclosporin.
Clin Kidney J
; 16(1): 151-158, 2023 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-36726439
7.
A systematic review of pregnancy-related clinical intervention of drug regimens due to pharmacokinetic reasons.
Front Med (Lausanne)
; 10: 1241456, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-38093976
8.
Understanding Statin-Roxadustat Drug-Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling.
Clin Pharmacol Ther
; 114(4): 825-835, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37376792
9.
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 92(3): 193-203, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37394627
10.
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.
Cancer Chemother Pharmacol
; 92(2): 141-150, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37368100
11.
Phase I Study of the Pharmacodynamics and Safety of Sodium Zirconium Cyclosilicate in Healthy Chinese Adults.
Clin Pharmacol Drug Dev
; 11(3): 348-357, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34997825
12.
Transient lower esophageal sphincter relaxation pharmacokinetic-pharmacodynamic modeling: count model and repeated time-to-event model.
J Pharmacol Exp Ther
; 339(3): 878-85, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21890509
13.
Evaluation of potential drug interactions with sodium zirconium cyclosilicate: a single-center, open-label, one sequence crossover study in healthy adults.
Clin Kidney J
; 14(7): 1808-1816, 2021 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-34221388
14.
Effects of sodium zirconium cyclosilicate on sodium and potassium excretion in healthy adults: a Phase 1 study.
Clin Kidney J
; 14(8): 1924-1931, 2021 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-34345416
15.
Pharmacokinetics of Roxadustat: A Population Analysis of 2855 Dialysis- and Non-Dialysis-Dependent Patients with Chronic Kidney Disease.
Clin Pharmacokinet
; 60(6): 759-773, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33486718
16.
A Systematic Review of Gastric Acid-Reducing Agent-Mediated Drug-Drug Interactions with Orally Administered Medications.
Clin Pharmacokinet
; 59(4): 447-462, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31788764
17.
Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 86(1): 97-108, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32556602
18.
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
J Med Chem
; 62(9): 4312-4324, 2019 05 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30869888
19.
The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.
PLoS One
; 12(12): e0189060, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29206860
20.
Chlorine interactions with water ice studied by molecular beam techniques.
J Phys Chem B
; 110(46): 23497-501, 2006 Nov 23.
Artigo
Inglês
| MEDLINE | ID: mdl-17107204