Detalhe da pesquisa
1.
An efficient system for stable markerless integration of large biosynthetic gene clusters into Streptomyces chromosomes.
Appl Microbiol Biotechnol
; 105(5): 2123-2137, 2021 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-33564923
2.
Genetic Engineering in Combination with Semi-Synthesis Leads to a New Route for Gram-Scale Production of the Immunosuppressive Natural Product Brasilicardinâ A.
Angew Chem Int Ed Engl
; 60(24): 13536-13541, 2021 06 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33768597
3.
An efficient blue-white screening system for markerless deletions and stable integrations in Streptomyces chromosomes based on the blue pigment indigoidine biosynthetic gene bpsA.
Appl Microbiol Biotechnol
; 102(23): 10231-10244, 2018 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-30259098
4.
Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains.
Appl Microbiol Biotechnol
; 102(2): 857-869, 2018 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-29196786
5.
Correction to: Increased heterologous production of the antitumoral polyketide mithramycin a by engineered Streptomyces lividans TK24 strains.
Appl Microbiol Biotechnol
; 102(2): 871, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29279959
6.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity.
Bioorg Med Chem Lett
; 22(13): 4310-3, 2012 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22647722
7.
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
Antimicrob Agents Chemother
; 55(4): 1638-49, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21263049
8.
A novel LysR-type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin.
Eng Life Sci
; 21(1-2): 4-18, 2021 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-33531886
9.
Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis.
Antimicrob Agents Chemother
; 54(5): 1684-92, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20176899
10.
Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma.
Mol Ther Oncolytics
; 18: 83-99, 2020 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32637583
11.
Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya.
Mol Microbiol
; 69(3): 633-45, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19138192
12.
The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling.
Front Immunol
; 10: 2455, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31681329
13.
Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia.
Mol Cancer Ther
; 17(3): 614-624, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29339551
14.
EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-κB.
Mol Cancer Ther
; 15(5): 806-18, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26826115
15.
High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio Technologies.
Genome Announc
; 4(6)2016 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27979943
16.
Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma.
Oncotarget
; 7(21): 30935-50, 2016 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-27105533
17.
Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.
Clin Cancer Res
; 22(16): 4105-18, 2016 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26979396
18.
The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya.
Chem Biol
; 10(4): 301-11, 2003 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-12725858
19.
Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy.
Toxicol In Vitro
; 29(7): 1537-44, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26079942
20.
Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2.
Oncotarget
; 6(32): 32856-67, 2015 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-26439989