Evaluation of fatigue in young female adults due to repeated exposure to heat in summer and cold in winter.

PURPOSE: The magnitude of fatigue (MF) from psychological and physiological responses during repeated exposure to heat in summer and during repeated exposure to cold in winter was evaluated to test two hypotheses on fatigue models. The first hypothesis is that exposure time (ET, min) would be a factor determining the MF and the second hypothesis is that the same fatigue models as a function of the number of exposure repetitions (NR) could be applied to both repeated exposure to heat in summer and cold in winter. METHODS: In summer, eight young adult female subjects with clothing insulation (Icl, clo) of 0.3 clo first stayed in the control room at 26 ℃ for 15 min, moved to the main testing room at 30 ℃ for 25 min, 33 °C for 15 min, or 36 ℃ for 10 min, and then returned to the control room. The product of air temperature difference (ΔTa, ℃) and ET was designed to be almost equal among these latter three conditions. The exposure was repeated five times. In winter, the same female subjects with Icl of 0.84 clo first stayed in the control room at 24 ℃ for 15 min, moved to the main testing room at 18 ℃ for 30 min, 15 ℃ for 20 min, or 12 ℃ for 15 min, and then returned to the control room. Again, the product of ΔTa and ET was designed to be equal among these latter three conditions. The exposure was repeated four times. The scores of subjective fatigue feeling (SFF) and salivary amylase value (SAV) were recorded when the subjects returned to the control room. Tympanic temperature, skin temperatures and local sweat rates (Sw, mg/cm2/min) at chest, forearm, front thigh, and front shin, and ECG were continuously monitored, except for Sw in the winter experiment. RESULTS: In the summer experiment, the SFF showed a threshold value at ΔTa = 4 ℃ but continuously increased with NR at ΔTa = 7 ℃ and 10 ℃. It was not correlated with ECG variables, but was positively correlated with SAV (R2 = 0.50) and the mean Sw (R2 = 0.76) at ΔTa = 7 ℃ and 10 ℃. In the winter experiment, the SFF showed a threshold value at ΔTa = - 6 ℃ but continuously increased with NR at ΔTa = - 9 ℃ and - 12 ℃. It was correlated with SAV at ΔTa = - 9 ℃ (R2 = 0.77) and score of LF: HF ratio at ΔTa = - 6 ℃ and - 9 ℃ (R2 = 0.49). CONCLUSION: It was confirmed that ET may be related to the MF and that different fatigue models may be applied dependent on ΔTa during repeated exposure to heat in summer and during repeated exposure to cold in winter. Thus, the two hypotheses were verified.

Tag-assisted liquid-phase peptide synthesis using hydrophobic benzyl alcohols as supports.

A soluble tag-assisted liquid-phase peptide synthesis was successfully established based on simple hydrophobic benzyl alcohols, which can be easily prepared from naturally abundant materials. Excellent precipitation yields can be obtained at each step, combining the best properties of solid-phase and liquid-phase techniques. This approach can also be applied efficiently to fragment couplings, allowing chemical synthesis of several bioactive peptides.

Development of outdoor thermal index indicating universal and separate effects on human thermal comfort.

The purpose of this study is to propose a new outdoor thermal index that simultaneously indicates universal and separate effects. The value indicating universal effect in this index consists of the summation of air temperature and the effective temperature differences by air velocity, longwave radiation, solar radiation, and humidity. This paper describes the theoretical construction of this newly derived index to compare with previous indices. The calculations of the new index are demonstrated using the observed data in order to explicitly indicate the specific features of the new index.

Feasibility evaluation of a new irradiation technique: three-dimensional unicursal irradiation with the Vero4DRT (MHI-TM2000).

The Vero4DRT (MHI-TM2000) is a newly designed unique image-guided radiotherapy system consisting of an O-ring gantry. This system can realize a new irradiation technique in which both the gantry head and O-ring continuously and simultaneously rotate around the inner circumference of the O-ring and the vertical axis of the O-ring, respectively, during irradiation. This technique creates three-dimensional (3D) rotational dynamic conformal arc irradiation, which we term '3D unicursal irradiation'. The aim of this study was to present the concept and to estimate feasibility and potential advantages of the new irradiation technique. Collision maps were developed for the technique and a 3D unicursal plan was experimentally created in reference to the collision map for a pancreatic cancer case. Thereafter, dosimetric comparisons among the 3D unicursal, a two-dimensionally rotational dynamic conformal arc irradiation (2D-DCART), and an intensity-modulated radiation therapy (IMRT) plan were conducted. Dose volume data of the 3D unicursal plan were comparable or improved compared to those of the 2D-DCART and IMRT plans with respect to both the target and the organs at risk. The expected monitor unit (MU) number for the 3D unicursal plan was only 7% higher and 22.1% lower than the MUs for the 2D-DCART plan and IMRT plan, respectively. It is expected that the 3D unicursal irradiation technique has potential advantages in both treatment time and dose distribution, which should be validated under various conditions with a future version of the Vero4DRT fully implemented the function.

Initial validations for pursuing irradiation using a gimbals tracking system.

Our newly designed image-guided radiotherapy (IGRT) system enables the dynamic tracking irradiation with a gimbaled X-ray head and a dual on-board kilovolt imaging subsystem for real-time target localization. Examinations using a computer-controlled three-dimensionally movable phantom demonstrated that our gimbals tracking system significantly reduced motion blurring effects in the dose distribution compared to the non-tracking state.

Effects of ambient temperature steps on thermal comfort requirements.

The purpose of this study was to determine the thermal comfort requirements for steps in temperature. Thirty male subjects were exposed for 50 min to a 34 or 37 degrees C condition, and then quickly transferred to a cooler environment of 31, 28, 25, and 22 degrees C for 50 min. Mean skin temperature was continuously measured, and the subjects reported their thermal sensation and comfort sensation every 2 min. Just after the step changes, the mean skin temperature immediately decreased, while the thermal sensation overshot and gradually rose again. Both the skin temperature and the thermal sensation seemed to reach a constant level within about 20 min. However, there were differences in the mean skin temperature and the neutral temperature derived from the correlation between the ambient temperature and the thermal sensation even 50 min after the steps, due to the thermal environmental condition before the changes of temperature. The change in the neutral temperature with time was expressed as two attenuating equations. These equations indicate that there is an obvious difference between the neutral temperatures due to the thermal condition before step changes, and that it takes >50 min after the step changes to reach the steady state. It is expected that these equations predict in quantitative terms the thermal comfort requirements within a given experimental condition.