Detalhe da pesquisa
1.
Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies.
Drug Metab Dispos
; 49(10): 870-881, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34321251
2.
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
Bioorg Med Chem Lett
; 25(3): 587-92, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25575658
3.
Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.
Bioorg Med Chem Lett
; 25(3): 581-6, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25556092
4.
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.
J Med Chem
; 65(6): 4600-4615, 2022 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35293760
5.
SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability.
Bioorg Med Chem Lett
; 20(17): 5039-43, 2010 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20675133
6.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33082276
7.
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun
; 10(1): 97, 2019 01 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30626872
8.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Nat Commun
; 10(1): 96, 2019 01 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30626880
9.
Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction.
J Clin Pharmacol
; 45(6): 631-9, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15901744
10.
Efficacy of dichloroacetate as a lactate-lowering drug.
J Clin Pharmacol
; 43(7): 683-91, 2003 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-12856382
11.
Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women.
J Clin Pharmacol
; 43(3): 243-51, 2003 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-12638392
12.
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.
J Clin Pharmacol
; 43(4): 386-96, 2003 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-12723459
13.
Microdialysis of triamcinolone acetonide in rat muscle.
J Pharm Sci
; 92(2): 394-7, 2003 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-12532388
14.
Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry.
Drug Metab Dispos
; 34(3): 384-8, 2006 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-16326814
15.
Population pharmacokinetics of digoxin in Egyptian pediatric patients: impact of one data point utilization.
Am J Ther
; 9(6): 492-8, 2002.
Artigo
Inglês
| MEDLINE | ID: mdl-12424506