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Nucleosides Nucleotides Nucleic Acids ; 27(10): 1197-210, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18788049

RESUMO

The present article deals with the synthesis of 2-chloroquinoline-3-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazone (CQCMH) (2a-c) and 2-chloroquinoline-3-carbaldehyde [4-(dimethylamino) benzylidene] hydrazone (CQCDBH) (3a-c) from quinoline derivatives under suitable experimental conditions. The synthesized compounds were characterized by elemental analysis, FTIR, (1)HNMR, and mass spectral data. The selected compounds were studied for interaction with calf thymus-DNA (CT-DNA) by electronic spectra, viscosity measurements as well as thermal denaturation studies. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. The binding constant (K(b)) had value of 2.3 x 10(3) M(-1) for (2a) and 2.5 x 10(4) M(-1) for (3a). The viscosity measurements indicated that the viscosity of sonicated rod like DNA fragments increased. The synthesized derivatives have been screened for antibacterial and antifungal activities.


Assuntos
Anti-Infecciosos/síntese química , DNA/metabolismo , Hidrazonas/síntese química , Quinolinas/síntese química , Bases de Schiff/síntese química , Anti-Infecciosos/metabolismo , Hidrazonas/metabolismo , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Quinolinas/metabolismo , Bases de Schiff/metabolismo , Espectroscopia de Infravermelho com Transformada de Fourier , Viscosidade
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