Detalhe da pesquisa
1.
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol Cell
; 82(9): 1643-1659.e10, 2022 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35334231
2.
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
J Enzyme Inhib Med Chem
; 39(1): 2313055, 2024 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-38416868
3.
Flow cytometric reporter assays provide robust functional analysis of signaling complexes.
J Biol Chem
; 298(12): 102666, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36334634
4.
The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs.
J Biol Chem
; 298(5): 101857, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35337798
5.
Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics.
Semin Cell Dev Biol
; 99: 96-114, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29738879
6.
Structural characterization of ß-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins
; 88(1): 47-56, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31237717
7.
Structural characterization of a short-chain dehydrogenase/reductase from multi-drug resistant Acinetobacter baumannii.
Biochem Biophys Res Commun
; 518(3): 465-471, 2019 10 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31443964
8.
Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signalling.
FEBS Lett
; 596(7): 886-897, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35038778
9.
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.
Science
; 377(6614): eadc8969, 2022 09 30.
Artigo
Inglês
| MEDLINE | ID: mdl-36048923
10.
Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing.
Acta Crystallogr F Struct Biol Commun
; 77(Pt 10): 364-373, 2021 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34605441
11.
Structural Evolution of TIR-Domain Signalosomes.
Front Immunol
; 12: 784484, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34868065
12.
Structural basis for nuclear import selectivity of pioneer transcription factor SOX2.
Nat Commun
; 12(1): 28, 2021 01 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33397924
13.
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Neuron
; 109(7): 1118-1136.e11, 2021 04 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33657413
14.
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun
; 12(1): 2578, 2021 05 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33972532
15.
Structure, function, and regulation of thioesterases.
Prog Lipid Res
; 79: 101036, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32416211
16.
Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling.
J Leukoc Biol
; 105(2): 363-375, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30517972
17.
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Science
; 365(6455): 793-799, 2019 08 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31439792
18.
Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes.
Sci Rep
; 7: 39277, 2017 01 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28045020
19.
Structural Characterisation of FabG from Yersinia pestis, a Key Component of Bacterial Fatty Acid Synthesis.
PLoS One
; 10(11): e0141543, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26539719
20.
Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis.
Sci Rep
; 5: 14797, 2015 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26469877