Detalhe da pesquisa
1.
NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.
PLoS Pathog
; 13(6): e1006343, 2017 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-28594932
2.
IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming.
Eur J Immunol
; 46(7): 1622-32, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27129615
3.
Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.
Gastroenterology
; 146(5): 1373-85.e1-11, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24512803
4.
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
Gastroenterology
; 147(2): 453-62.e7, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24768676
5.
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Blood
; 122(6): 932-42, 2013 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-23794066
6.
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
PLoS Pathog
; 8(3): e1002576, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22412376
7.
Hepatitis C virus-specific directly acting antiviral drugs.
Curr Top Microbiol Immunol
; 369: 289-320, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23463206
8.
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture.
Bioorg Med Chem Lett
; 19(6): 1779-83, 2009 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19216075
9.
NS5A phosphorylation and hyperphosphorylation.
Methods Mol Biol
; 510: 95-110, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-19009256
10.
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorg Med Chem Lett
; 18(6): 1814-9, 2008 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18308563
11.
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Nat Microbiol
; 2: 16247, 2016 12 19.
Artigo
Inglês
| MEDLINE | ID: mdl-27991882
12.
Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.
PLoS One
; 10(9): e0138546, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26405760
13.
Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Nat Microbiol
; 2: 17012, 2017 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-28112725
14.
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain.
J Biol Chem
; 283(39): 26694-704, 2008 Sep 26.
Artigo
Inglês
| MEDLINE | ID: mdl-18614528
15.
Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.
J Biol Chem
; 282(8): 5536-44, 2007 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-17166835
16.
The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation.
J Virol
; 80(22): 11305-12, 2006 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-16943283
17.
High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein.
J Virol
; 78(7): 3502-13, 2004 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-15016873
18.
Determination of the stoichiometry of noncovalent complexes using reverse-phase high-performance liquid chromatography coupled with electrospray ion trap mass spectrometry.
Anal Biochem
; 309(1): 11-8, 2002 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12381356
19.
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture.
J Virol
; 78(23): 13306-14, 2004 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-15542681
20.
A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR.
EMBO Rep
; 4(2): 159-65, 2003 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-12612605