RESUMO
Pericarditis is an uncommon pathology that represents 0.1% of patients hospitalized for chest pain with a wide etiological spectrum and whose cause is uncommonly highlighted. In order to determine the incidence of specific acute microbiological or autoimmune pericarditis and identify subsets of patients with a higher incidence of specific etiologies; and analyze the conformity of the management of acute pericarditis according to the recommendations, a retrospective inclusion of all patients admitted to our hospital from January 2010 to December 2018 with the diagnosis of acute pericarditis was conducted. Data concerning clinical, paraclinical and treatment items were collected. Ninety-nine patients were included. Specific etiologic exams were completely conducted in 63.6% of the patients. There was no link between the decision to conduct etiology exams and the age, gender, a history of acute pericarditis or relapse. There was a trend between an elevated CRP and the realization of the kit. There was a statistically significant link between the achievement of etiologic exams and the presence of severity criteria or the presence of a pericardial effusion. An etiology was found in 52.4%, more frequently microbiological (viral and Mycoplasma pneumoniae). Approximately 85.9% of all patients were hospitalized. Treatment was in accordance with the recommendations in 76.8%. Despite the percentage of microbiological etiologies found, it does not impact the therapeutic strategy. The criteria for hospitalization must be better suited since half of those hospitalized after the european society of cardiology (ESC) 2015 recommendations had no need to be. However, monitoring after discharge is not clearly defined by learned societies.
Assuntos
Pericardite , Doença Aguda , Cardiologia , Humanos , Incidência , Derrame Pericárdico , Pericardite/diagnóstico , Pericardite/etiologia , Pericardite/terapia , Estudos RetrospectivosRESUMO
Using a neonatal rat meningitis model, we examined the involvement of three iron uptake systems, namely, the high-pathogenicity island, the hemin receptor ChuA, and the siderophore receptor IroN, in the pathogenesis of Escherichia coli neonatal meningitis. Only IroN appeared to play a major role during the bacteremic step of the disease.
Assuntos
Bacteriemia/etiologia , Proteínas da Membrana Bacteriana Externa/fisiologia , Infecções por Escherichia coli/etiologia , Proteínas de Escherichia coli/fisiologia , Escherichia coli/patogenicidade , Ferro/metabolismo , Meningites Bacterianas/etiologia , Receptores de Superfície Celular/fisiologia , Animais , Animais Recém-Nascidos , Proteínas da Membrana Bacteriana Externa/genética , Sequência de Bases , Escherichia coli/metabolismo , Proteínas de Escherichia coli/genética , Dados de Sequência Molecular , Ratos , Ratos Sprague-Dawley , Receptores de Superfície Celular/genética , VirulênciaRESUMO
We describe a case of culture-negative meningitis and endocarditis caused by Streptococcus agalactiae in a 27-day-old boy. S. agalactiae was detected in cerebrospinal fluid and serum by broad-spectrum PCR amplification.