Detalhe da pesquisa
1.
3-Substituted Quinolines as RORγt Inverse Agonists.
Bioorg Med Chem Lett
; 29(12): 1463-1470, 2019 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31010722
2.
Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry.
J Chem Inf Model
; 59(5): 2046-2062, 2019 05 28.
Artigo
Inglês
| MEDLINE | ID: mdl-30817167
3.
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Bioorg Med Chem Lett
; 28(9): 1446-1455, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29631962
4.
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Proc Natl Acad Sci U S A
; 111(33): 12163-8, 2014 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25092323
5.
Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.
Structure
; 29(3): 238-251.e4, 2021 03 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33238146
6.
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
J Med Chem
; 60(8): 3511-3517, 2017 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28300404
7.
RORγt and RORα signature genes in human Th17 cells.
PLoS One
; 12(8): e0181868, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28763457
8.
Universal screening methods and applications of ThermoFluor.
J Biomol Screen
; 11(7): 854-63, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16943390
9.
Affinity assays for decrypting protein targets of unknown function.
Drug Discov Today Technol
; 2(3): 267-73, 2005.
Artigo
Inglês
| MEDLINE | ID: mdl-24981946
10.
Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy. II. Effects of core heteroatoms and meso-substituents on biological activity.
J Med Chem
; 45(2): 449-61, 2002 Jan 17.
Artigo
Inglês
| MEDLINE | ID: mdl-11784149
11.
Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.
J Biol Chem
; 280(12): 11704-12, 2005 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-15634672
12.
Synthesis and mass spectrometry studies of branched oxime ether libraries. Mapping the substitution motif via linker stability and fragmentation pattern.
J Org Chem
; 67(1): 59-65, 2002 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-11777439