Pesquisa | Secretaria de Estado da Saúde

1.

Gut microbial carbohydrate metabolism contributes to insulin resistance.

Takeuchi, Tadashi; Kubota, Tetsuya; Nakanishi, Yumiko; Tsugawa, Hiroshi; Suda, Wataru; Kwon, Andrew Tae-Jun; Yazaki, Junshi; Ikeda, Kazutaka; Nemoto, Shino; Mochizuki, Yoshiki; Kitami, Toshimori; Yugi, Katsuyuki; Mizuno, Yoshiko; Yamamichi, Nobutake; Yamazaki, Tsutomu; Takamoto, Iseki; Kubota, Naoto; Kadowaki, Takashi; Arner, Erik; Carninci, Piero; Ohara, Osamu; Arita, Makoto; Hattori, Masahira; Koyasu, Shigeo; Ohno, Hiroshi.

Nature ; 621(7978): 389-395, 2023 Sep.

Artigo Inglês | MEDLINE | ID: mdl-37648852

2.

Characterization of metabolic phenotypes and distinctive genes in mice with low-weight gain.

Nemoto, Shino; Kubota, Tetsuya; Ishikura, Tomoyuki; Nakayama, Manabu; Kobayashi, Atsuo; Yazaki, Junshi; Uchida, Kazuyo; Matsuda, Masashi; Kondo, Takashi; Ohara, Osamu; Koseki, Haruhiko; Koyasu, Shigeo; Ohno, Hiroshi.

FASEB J ; 38(1): e23339, 2024 01.

Artigo Inglês | MEDLINE | ID: mdl-38069905

3.

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.

Wang, Chuangui; Chen, Lihong; Hou, Xinghua; Li, Zhenyu; Kabra, Neha; Ma, Yihong; Nemoto, Shino; Finkel, Toren; Gu, Wei; Cress, W Douglas; Chen, Jiandong.

Nat Cell Biol ; 8(9): 1025-31, 2006 Sep.

Artigo Inglês | MEDLINE | ID: mdl-16892051

4.

Exploring body weight-influencing gut microbiota by elucidating the association with diet and host gene expression.

Nemoto, Shino; Kubota, Tetsuya; Ohno, Hiroshi.

Sci Rep ; 13(1): 5593, 2023 04 05.

Artigo Inglês | MEDLINE | ID: mdl-37019989

5.

Metabolic differences and differentially expressed genes between C57BL/6J and C57BL/6N mice substrains.

Nemoto, Shino; Kubota, Tetsuya; Ohno, Hiroshi.

PLoS One ; 17(12): e0271651, 2022.

Artigo Inglês | MEDLINE | ID: mdl-36548271

6.

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.

Smith, Wanli W; Norton, Darrell D; Gorospe, Myriam; Jiang, Haibing; Nemoto, Shino; Holbrook, Nikki J; Finkel, Toren; Kusiak, John W.

J Cell Biol ; 169(2): 331-9, 2005 Apr 25.

Artigo Inglês | MEDLINE | ID: mdl-15837797

7.

Ageing and the mystery at Arles.

Nemoto, Shino; Finkel, Toren.

Nature ; 429(6988): 149-52, 2004 May 13.

Artigo Inglês | MEDLINE | ID: mdl-15141200

8.

Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.

Arai, Satoko; Miyake, Katsuhisa; Voit, Renate; Nemoto, Shino; Wakeland, Edward K; Grummt, Ingrid; Miyazaki, Toru.

Proc Natl Acad Sci U S A ; 104(7): 2289-94, 2007 Feb 13.

Artigo Inglês | MEDLINE | ID: mdl-17283331

9.

Phosphatidylinositol 3-kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1.

Kristof, Arnold S; Fielhaber, Jill; Triantafillopoulos, Alexandra; Nemoto, Shino; Moss, Joel.

J Biol Chem ; 281(33): 23958-68, 2006 Aug 18.

Artigo Inglês | MEDLINE | ID: mdl-16687394

10.

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.

Nemoto, Shino; Combs, Christian A; French, Stephanie; Ahn, Bong-Hyun; Fergusson, Maria M; Balaban, Robert S; Finkel, Toren.

J Biol Chem ; 281(15): 10555-60, 2006 Apr 14.

Artigo Inglês | MEDLINE | ID: mdl-16481327

11.

Mitochondria, oxidants, and aging.

Balaban, Robert S; Nemoto, Shino; Finkel, Toren.

Cell ; 120(4): 483-95, 2005 Feb 25.

Artigo Inglês | MEDLINE | ID: mdl-15734681

12.

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.

Nemoto, Shino; Fergusson, Maria M; Finkel, Toren.

J Biol Chem ; 280(16): 16456-60, 2005 Apr 22.

Artigo Inglês | MEDLINE | ID: mdl-15716268

13.

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.

Nemoto, Shino; Finkel, Toren.

Science ; 295(5564): 2450-2, 2002 Mar 29.

Artigo Inglês | MEDLINE | ID: mdl-11884717

14.

Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).

Ichida, Masaru; Nemoto, Shino; Finkel, Toren.

J Biol Chem ; 277(52): 50991-5, 2002 Dec 27.

Artigo Inglês | MEDLINE | ID: mdl-12397057

15.

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

Nemoto, Shino; Fergusson, Maria M; Finkel, Toren.

Science ; 306(5704): 2105-8, 2004 Dec 17.

Artigo Inglês | MEDLINE | ID: mdl-15604409

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