RESUMO
Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. Aspects of the children's intellectual and motor development, school achievement, and social-emotional functioning were investigated. There were no differences between the corticoid group and the placebo group on these variables, nor were there more children with learning difficulties and behavioral disturbances in either of the groups.
Assuntos
Betametasona/efeitos adversos , Desenvolvimento Infantil/efeitos dos fármacos , Efeitos Tardios da Exposição Pré-Natal , Psicologia da Criança , Síndrome do Desconforto Respiratório do Recém-Nascido/prevenção & controle , Criança , Feminino , Seguimentos , Humanos , Recém-Nascido , Masculino , Análise Multivariada , Placebos , Gravidez , Testes Psicológicos , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. The children had a general physical examination; parents were interviewed about the medical history of their child with special attention to infectious diseases; growth data were collected; and a developmental neurological examination, an ophthalmological examination, and a lung function test were conducted. In the corticosteroid group significantly more hospital admissions because of infectious diseases during the first years of life were reported. On the other variables no differences between the corticoid and the placebo groups were found.