Detalhe da pesquisa
1.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol Cell
; 73(3): 621-638.e17, 2019 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30554943
2.
Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
Nucleic Acids Res
; 51(1): 475-487, 2023 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36546776
3.
Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Nucleic Acids Res
; 51(18): 9920-9937, 2023 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37665033
4.
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
Mol Cell
; 64(4): 704-719, 2016 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-27871366
5.
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Nucleic Acids Res
; 49(16): 9294-9309, 2021 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34387694
6.
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Nucleic Acids Res
; 49(16): 9310-9326, 2021 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34387696
7.
The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.
J Biol Chem
; 295(10): 2948-2958, 2020 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31914405
8.
RECQL5: Another DNA helicase potentially involved in hereditary breast cancer susceptibility.
Hum Mutat
; 40(5): 566-577, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30817846
9.
Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes.
J Biol Chem
; 293(33): 12862-12876, 2018 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29880640
10.
Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res
; 45(7): 4231-4243, 2017 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28100692
11.
The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.
Nucleic Acids Res
; 43(22): 11047-60, 2015 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26582912
12.
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Nucleic Acids Res
; 43(10): 5221-35, 2015 May 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25901030
13.
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.
J Biol Chem
; 290(22): 13692-709, 2015 May 29.
Artigo
Inglês
| MEDLINE | ID: mdl-25866208
14.
Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2.
J Biol Chem
; 290(13): 8539-49, 2015 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25670864
15.
The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis.
J Bacteriol
; 196(2): 265-75, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24163345
16.
Molecular basis of the activity of SinR protein, the master regulator of biofilm formation in Bacillus subtilis.
J Biol Chem
; 288(15): 10766-78, 2013 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-23430750
17.
Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.
Biochem Soc Trans
; 42(1): 130-8, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24450640
18.
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.
Chem Sci
; 15(21): 8227-8241, 2024 May 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38817593
19.
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Nat Commun
; 12(1): 4848, 2021 08 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34381037
20.
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Life Sci Alliance
; 4(1)2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33199508