Detalhe da pesquisa
1.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Immunity
; 56(9): 2121-2136.e6, 2023 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37659412
2.
Deep learning-based identification of genetic variants: application to Alzheimer's disease classification.
Brief Bioinform
; 23(2)2022 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35183061
3.
Transcriptional risk scores in Alzheimer's disease: From pathology to cognition.
Alzheimers Dement
; 20(1): 243-252, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37563770
4.
The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.
Alzheimers Dement
; 20(1): 652-694, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37698424
5.
Integrative-omics for discovery of network-level disease biomarkers: a case study in Alzheimer's disease.
Brief Bioinform
; 22(6)2021 11 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33971669
6.
Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer's biomarkers.
Mol Psychiatry
; 27(2): 1256-1273, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35087196
7.
Genome-wide association study of occupational attainment as a proxy for cognitive reserve.
Brain
; 145(4): 1436-1448, 2022 05 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34613391
8.
Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
Brain
; 145(7): 2541-2554, 2022 07 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35552371
9.
Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC.
Alzheimers Dement
; 19(4): 1234-1244, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35971593
10.
Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles.
Alzheimers Dement
; 19(11): 5173-5184, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37166019
11.
A simulative deep learning model of SNP interactions on chromosome 19 for predicting Alzheimer's disease risk and rates of disease progression.
Alzheimers Dement
; 19(12): 5690-5699, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37409680
12.
Progress in Polygenic Composite Scores in Alzheimer's and Other Complex Diseases.
Trends Genet
; 35(5): 371-382, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30922659
13.
MicroRNA-298 reduces levels of human amyloid-ß precursor protein (APP), ß-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties.
Mol Psychiatry
; 26(10): 5636-5657, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31942037
14.
Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging.
Mol Psychiatry
; 26(1): 309-321, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30361487
15.
Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease.
Alzheimers Dement
; 18(6): 1260-1278, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34757660
16.
APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.
Alzheimers Dement
; 18(11): 2151-2166, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35077012
17.
INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.
Neurobiol Dis
; 153: 105303, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33631273
18.
Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
PLoS Med
; 18(5): e1003615, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34043628
19.
Genetic variants and functional pathways associated with resilience to Alzheimer's disease.
Brain
; 143(8): 2561-2575, 2020 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32844198
20.
Common genetic variants influence human subcortical brain structures.
Nature
; 520(7546): 224-9, 2015 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25607358