[A long-term follow-up of the correlation between obstructive sleep apnea hypopnea syndrome and multiple organ diseases].

OBJECTIVE: To explore the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and multiple organ diseases. METHODS: Home-visit questionnaires were performed in 1 868 subjects (956 male, 912 female) with an average age of (79 ± 5) years, and a prospective follow-up was performed for a period of 20 years with annual medical examinations. Multiple organ diseases included hypertension, coronary heart disease, stroke, diabetes, pulmonary heart disease, renal insufficiency and erythrocytosis. The subjects were grouped by the diagnosis of OSAHS. RESULTS: Among the 1 868 subjects, 598 (32.0%) were diagnosed with OSAHS, and 1 270 (68.0%) of non-OSAHS as the control group. By the end of follow-up, in the OSAHS group there were 477 (79.8%) cases with hypertension, 337 (56.4%) cases with coronary heart disease, 167 (27.9%) cases with stroke, 76 (12.7%) cases with diabetes, 37 (6.2%) cases with pulmonary heart disease, 73 (12.2%) cases with renal insufficiency and 211(35.3%) cases with erythrocytosis, all of which were significantly higher than those of the control group [323(25.4%), 315 (24.8%), 95 (7.5%), 69 (5.4%), 40 (3.2%), 58 (4.6%), 30 (2.4%), P < 0.01]. The number of diseases in the OSAHS group was also higher than that in the control group (P < 0.05) . CONCLUSION: The incidence of multiple organ diseases was remarkably higher in the OSAHS group than that in the control group, which indicated that OSAHS was a risk factor for multiple organ diseases. These diseases in OSAHS patients may be related to hypoxia caused by OSAHS, endocrine and metabolic disorders, unhealthy lifestyles and arteriosclerosis.

[Twenty years follow-up: the correlation between sleep apnea syndrome and cerebrovascular disease].

OBJECTIVE: To explore the correlation between obstructive sleep apnea syndrome (OSAS) and cerebrovascular disease (CVD). METHODS: A cohort of 1868 people was screened for OSAS, and followed from November 1989 to November 2009. Annual medical examinations including blood pressure, blood fat, serum glucose, electrocardiogram and chest x-ray were performed. Computer tomography was carried out when CVD, the endpoint of the study, was manifested. RESULTS: Among the 1868 elderly people, 598 (32.0%) were confirmed to have OSAS, including 496 (82.9%) males and 102 (17.1%) females. Compared with the non-OSAS group, patients with OSAS had more symptoms including daytime somnolence, headache, decreased ability of memory, aphronesia and allolalia (P < 0.05). CVD occurred in 276 (46.2%) patients of the OSAS group, but in 150 (11.8%, P < 0.01) subjects of the non-OSAS group. During the 20-year follow-up, 817 people died, 66.2% (396/598) in the OSAS group, but 33.1% (421/1270) in the non-OSAS group (P < 0.01). CONCLUSION: Patients with OSAS are more likely to suffer from CVD. OSAS may be an independent risk factor for CVD.