Detalhe da pesquisa
1.
Discovery of novel and potent dual-targeting AXL/HDAC2 inhibitors for colorectal cancer treatment via structure-based pharmacophore modelling, virtual screening, and molecular docking, molecular dynamics simulation studies, and biological evaluation.
J Enzyme Inhib Med Chem
; 39(1): 2295241, 2024 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-38134358
2.
Discovery and biological evaluation of novel CARM1/HDAC2 dual-targeting inhibitors with anti-prostate cancer agents.
J Enzyme Inhib Med Chem
; 38(1): 2241118, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37528657
3.
Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation.
J Enzyme Inhib Med Chem
; 38(1): 2220558, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37357755
4.
Highly Potent, Selective, Biostable, and Cell-Permeable Cyclic d-Peptide for Dual-Targeting Therapy of Lung Cancer.
J Am Chem Soc
; 144(16): 7117-7128, 2022 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-35417174
5.
Association between serum uric acid and carotid atherosclerosis in elderly postmenopausal women: A hospital-based study.
J Clin Lab Anal
; 36(1): e24097, 2022 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-34837265
6.
Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity.
Molecules
; 24(17)2019 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31480625
7.
Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors.
Molecules
; 24(23)2019 Nov 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31766720
8.
Discovery of a Potent PLK1-PBD Small-Molecule Inhibitor as an Anticancer Drug Candidate through Structure-Based Design.
Molecules
; 24(23)2019 Nov 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31795214
9.
Structure-Based Virtual Screening and Biological Evaluation of Peptide Inhibitors for Polo-Box Domain.
Molecules
; 25(1)2019 Dec 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31892137
10.
Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors.
Bioorg Med Chem
; 26(12): 3429-3437, 2018 07 23.
Artigo
Inglês
| MEDLINE | ID: mdl-29807699
11.
Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking.
Acta Pharmacol Sin
; 35(7): 967-79, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24909516
12.
Discovery of a dual-target DYRK2 and HDAC8 inhibitor for the treatment of hepatocellular carcinoma.
Biomed Pharmacother
; 177: 116839, 2024 Jun 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38889633
13.
Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer.
J Med Chem
; 67(9): 7130-7145, 2024 May 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38630077
14.
[Effect of continuous cropping of Rehmannia on its morphological and physiological characteristics].
Zhong Yao Cai
; 36(5): 691-5, 2013 May.
Artigo
Chinês
| MEDLINE | ID: mdl-24218955
15.
Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity.
Front Pharmacol
; 14: 1208740, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37492092
16.
Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation.
J Med Chem
; 66(23): 16187-16200, 2023 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38093696
17.
Dual-targeting cyclic peptides of receptor-binding domain (RBD) and main protease (Mpro) as potential drug leads for the treatment of SARS-CoV-2 infection.
Front Pharmacol
; 13: 1041331, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36339564
18.
Discovery of potent and noncovalent KRASG12D inhibitors: Structure-based virtual screening and biological evaluation.
Front Pharmacol
; 13: 1094887, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36618907
19.
Non-covalent cyclic peptides simultaneously targeting Mpro and NRP1 are highly effective against Omicron BA.2.75.
Front Pharmacol
; 13: 1037993, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36408220
20.
An NRP1/MDM2-Targeted D-Peptide Supramolecular Nanomedicine for High-Efficacy and Low-Toxic Liver Cancer Therapy.
Adv Healthc Mater
; 10(9): e2002197, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33690977