RESUMO
Superoxide radical (O2-) is a free radical that may be involved in various toxic processes. Cu-Zn superoxide dismutase catalyzes the dismutation of the superoxide free radical and protects cells from oxidative damage. A rat bioassay validated for the identification of the toxic effects of azomethine H revealed increased serum activities of amylase, alanine transaminase, and alkaline phosphatase. The lipoperoxide and bilirubin concentrations were also increased in animals that received azomethine H (1 g/kg) from ascorbic or hydrochloric acid solutions. Azomethine H increased Cu-Zn superoxide dismutase activity. This elevation of Cu-Zn superoxide dismutase activity was highest on the 7th day and was at levels comparable with those of control rats from day 60 onwards. Superoxide is an important intermediate in the action and toxicity of azomethine H.
Assuntos
Antimaláricos/farmacologia , Naftalenossulfonatos/farmacologia , Oxigênio/metabolismo , Tiossemicarbazonas/farmacologia , Animais , Ativação Enzimática/efeitos dos fármacos , Peróxidos Lipídicos/sangue , Masculino , Ratos , Ratos Wistar , Superóxido Dismutase/sangue , Fatores de TempoRESUMO
BACKGROUND: The present report was carried out to determine whether alcohol intake could induce prostate lesions. METHODS: We tested male rats for 300 days. Animals were divided into three groups: controls received only tap water as liquid diet; the chronic alcohol intake group received only ethanol solution in semivoluntary research; and the withdrawal group received the same treatment as chronic alcohol intake until 240 days, after which they reverted to drinking water. RESULTS: Chronic alcohol intake increased lipoperoxide concentrations and acid phosphatase activities. Cu-Zn superoxide dismutase (SOD) was decreased at 60 days, but approached controls values at 300 days following treatment. The serum increased alkaline phosphatase, and alanine transaminase activities reflected the chronic toxic effect of ethanol. CONCLUSIONS: Since SOD activity was unable to scavenge superoxide radical and lipoperoxide formation, we can conclude that superoxide is an important intermediate in prostate damage of chronic alcohol intake.
Assuntos
Consumo de Bebidas Alcoólicas/sangue , Etanol/efeitos adversos , Próstata/efeitos dos fármacos , Alanina Transaminase/sangue , Fosfatase Alcalina/sangue , Animais , Peso Corporal/efeitos dos fármacos , Masculino , Próstata/metabolismo , Ratos , Ratos Wistar , Superóxido Dismutase/sangueRESUMO
Se presenta una experiencia con la tecnica de esofagectomia total sin toracotomia para el tratamiento del cancer esofagico o faringoesofagico segun fuera practicada en 4 pacientes. Se describe la tecnica utilizada, se discuten las indicaciones de la misma y se explicita la conducta que se sigue en el tratamiento de estos paciente
Assuntos
Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Esofagoplastia , Neoplasias EsofágicasRESUMO
Se presenta una experiencia con la tecnica de esofagectomia total sin toracotomia para el tratamiento del cancer esofagico o faringoesofagico segun fuera practicada en 4 pacientes. Se describe la tecnica utilizada, se discuten las indicaciones de la misma y se explicita la conducta que se sigue en el tratamiento de estos paciente