RESUMO
At the beginning of this century, there was a paradigm shift in understanding the histogenesis of high-grade serous carcinomas. The theory of the origin of these tumors from the ovarian surface epithelium was replaced by the concept of their origin from the secretory epithelium of the fallopian tubes. In recent years, researchers have put forward the hypothesis of the "escape" of the precursor of high-grade serous carcinomas. It allows looking at the carcinogenesis of these neoplasms as a natural history of tumor transformation of the serous epithelium without reference to a specific localization.
Assuntos
Carcinoma in Situ , Cistadenocarcinoma Seroso , Neoplasias Ovarianas , Humanos , Feminino , Neoplasias Ovarianas/patologia , Cistadenocarcinoma Seroso/genética , Cistadenocarcinoma Seroso/patologia , Epitélio/patologia , Tubas Uterinas/patologia , CarcinogêneseRESUMO
On the samples of 26 prostatectomies, the method of excision of the prostate gland according to Kim was tested. This method increased the number of blocks by 30.2% and increased the detectability of extraprostatic extension by 41.7% and positive surgical margin by 40.0% compared to the method of alternate prostate sections. Also, the method according to Kim reduced the number of blocks of prostate tissue by 34.3% compared to the method of complete prostate excision.
Assuntos
Margens de Excisão , Neoplasias da Próstata , Masculino , Humanos , Neoplasias da Próstata/cirurgia , Neoplasias da Próstata/diagnóstico , Próstata/cirurgia , Prostatectomia/métodos , Invasividade NeoplásicaRESUMO
Seromucinous tumors belong to a group of ovarian epithelial tumors. They were originally described as tumors characterized by Müllerian endocervical differentiation. Molecular genetic studies have indicated these tumors as endometriosis-associated tumors due to the presence of ARID1 gene mutations. However, the histogenesis of these neoplasms is still unstudied.