Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature.

Benign osteoblastoma is a rarely seen tumor of the facial bones. The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus. The histopathological diagnosis was one of osteoblastoma. Postoperative recurrence with soft tissue infiltration suggested an osteosarcoma radiologically, but the histological examination again revealed the presence of an osteoblastoma. A second recurrence occured in the pharyngo-glossal region and this time the tumor was histologically diagnosed as an osteoblastoma, but with foci of well-differentiated osteosarcoma. The patient was given a course of radiotherapy, but clinical and radiological examination 8 months later revealed lung metastases and chemotherapy was started. Unfortunately, the patient died months later. While osteoblastomas are rare, and their sarcomatous change even rarer, our experience with this case lead us to suggest that a therapeutic preventative approach, involving both chemotherapy and total excision of the tumor, is the regime to adopt with osteoblastomas which involve soft tissues and have radiological features suggesting malignancy.

[Metastatic breast cancer of the mandible. Case report]. / Przerzut raka sutka do zuchwy. Opis przypadku.

The authors describe the case of the rare location breast cancer metastasis to the lower jaw, 24 months after primary tumor removal. Clinical symptoms and additional examinations suggested the new neoplastic focus. Histopathological study of the operating material brought to light the origin of the change.

[Malignant tumors of the oral cavity and neck in clinic of maxillo-facial surgery in Poznan from 2002-2004]. / Nowotwory zlosiwe jamy ustnej i szyi w materiale kliniki chirurgii szczekowo-twarzowej w Poznaniu w okresie 2002-2004.

UNLABELLED: Increasing number of malignant neoplasms of the oral cavity and facial region as well as lower age of the patients hospitalized were the interest of the authors. MATERIAL AND METHODS: Clinical data from the years 2002-2004 were analysed in this paper. In this study the factors as: sex and age of patients, tumor localization, histological examinations, surgical treatment of the tumor and lymph nodes are reported. RESULTS: During the 3 years period there were 346 tumors of the oral cavity treated in Clinic of Maxillofacial Surgery in Poznan. Epidemiologic studies have revealed a increased number of squamous cell carcinomas and other malignant tumors as lymphomas, adenoid cystic carcinomas and sarcomas of the oro-facial region. The staging of the tumors is similar as in previous years. CONCLUSIONS: The study shows better knowledge about oral malignancies in dentists and general praticioners. The tumor patients are surgically treated earlyer as in previous years.

[Expression of factors inducing apoptosis of peripheral blood lymphocytes in oral cavity cancers]. / Ocena ekspresji bialek indukujacych apoptoze limfocytów krwi obwodowej chorych z rakiem jamy ustnej.

One of possible immunosuppression mechanisms during cancer disease is apoptotic death of immunology system cells. Factor FAS and xi chain of TCR-CD3 complex take part in induction of apoptosis of lymphocyte which infiltrate neoplasm as well as lymphocytes of peripheral blood (PBL). Expression of the two factors was estimated in PBL of patients with cancer of bottom of oral cavity and granuloma fissuratum (control group). During cancer disease higher level of FAS factor in PBL was observed in comparison to control group. Lymphocytes of peripheral blood in cases of cancer disease shown lower expression of TCR-xi.