Detalhe da pesquisa
1.
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Cell
; 186(5): 1013-1025.e24, 2023 03 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36827973
2.
High-Dose Isoniazid Lacks EARLY Bactericidal Activity Against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized, Phase 2 Clinical Trial.
Am J Respir Crit Care Med
; 2024 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38564365
3.
Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis.
Annu Rev Pharmacol Toxicol
; 61: 495-516, 2021 01 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32806997
4.
Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 68(4): e0156223, 2024 Apr 03.
Artigo
Inglês
| MEDLINE | ID: mdl-38376228
5.
Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis.
Antimicrob Agents Chemother
; 67(12): e0078923, 2023 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37966090
6.
Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis.
Antimicrob Agents Chemother
; 67(7): e0153222, 2023 07 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37255473
7.
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model.
Antimicrob Agents Chemother
; 67(4): e0003523, 2023 04 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36920217
8.
Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy.
Antimicrob Agents Chemother
; 67(7): e0048123, 2023 07 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37338374
9.
Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs.
Eur Respir J
; 62(2)2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37321622
10.
Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy.
Am J Respir Crit Care Med
; 205(5): 570-579, 2022 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34939891
11.
Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial.
Am J Respir Crit Care Med
; 205(10): 1228-1235, 2022 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35258443
12.
Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment.
Clin Infect Dis
; 75(Suppl 4): S510-S516, 2022 11 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36410384
13.
CRISPR Inhibition of Essential Peptidoglycan Biosynthesis Genes in Mycobacterium abscessus and Its Impact on ß-Lactam Susceptibility.
Antimicrob Agents Chemother
; 66(4): e0009322, 2022 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35311518
14.
Model-Based Meta-Analysis of Relapsing Mouse Model Studies from the Critical Path to Tuberculosis Drug Regimens Initiative Database.
Antimicrob Agents Chemother
; 66(3): e0179321, 2022 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35099274
15.
T405, a New Penem, Exhibits In Vivo Efficacy against M. abscessus and Synergy with ß-Lactams Imipenem and Cefditoren.
Antimicrob Agents Chemother
; 66(6): e0053622, 2022 06 21.
Artigo
Inglês
| MEDLINE | ID: mdl-35638855
16.
Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models.
Antimicrob Agents Chemother
; 66(4): e0239821, 2022 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35315690
17.
Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments.
Antimicrob Agents Chemother
; 66(4): e0231021, 2022 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35311519
18.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother
; 66(6): e0013222, 2022 06 21.
Artigo
Inglês
| MEDLINE | ID: mdl-35607978
19.
One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis.
N Engl J Med
; 380(11): 1001-1011, 2019 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30865794
20.
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
PLoS Pathog
; 16(2): e1008287, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32032366