Detalhe da pesquisa
1.
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
Bioorg Med Chem Lett
; 29(20): 126611, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31447084
2.
Acute-on-chronic liver failure: The challenge of PREDICTing who and when.
J Hepatol
; 73(4): 755-756, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32800351
3.
Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure.
Hepatology
; 59(4): 1564-76, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24282114
4.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
ACS Chem Neurosci
; 13(6): 751-765, 2022 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-35245037
5.
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Bioorg Med Chem Lett
; 20(15): 4639-44, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20579874
6.
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Bioorg Med Chem Lett
; 19(13): 3669-73, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19477642
7.
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Bioorg Med Chem Lett
; 19(13): 3664-8, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19428244
8.
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Bioorg Med Chem Lett
; 19(13): 3674-8, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19406640
9.
Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
J Med Chem
; 51(11): 3313-7, 2008 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-18457381
10.
BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Bioorg Med Chem Lett
; 18(3): 1017-21, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18166458
11.
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Bioorg Med Chem Lett
; 18(3): 1011-6, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18171614
12.
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Bioorg Med Chem Lett
; 18(3): 1022-6, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18171615
13.
Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.
Mol Cancer Ther
; 10(9): 1542-52, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21764904