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BACKGROUND: During the COVID-19 pandemic, United Kingdom (UK) stop smoking services had to shift to remote delivery models due to social distancing regulations, later reintroducing face-to-face provision. The "Living Well Smokefree" service in North Yorkshire County Council adopted a hybrid model offering face-to-face, remote, or a mix of both. This evaluation aimed to assess the hybrid approach's strengths and weaknesses and explore potential improvements. METHODS: Conducted from September 2022 to February 2023, the evaluation consisted of three components. First, qualitative interviews involved 11 staff and 16 service users, analysed thematically. Second, quantitative data from the QuitManager system that monitored the numbers and proportions of individuals selecting and successfully completing a 4-week quit via each service option. Third, face-to-face service expenses data was used to estimate the value for money of additional face-to-face provision. The qualitative findings were used to give context to the quantitative data via an "expansion" approach and complementary analysis. RESULTS: Overall, a hybrid model was seen to provide convenience and flexible options for support. In the evaluation, 733 individuals accessed the service, with 91.3% selecting remote support, 6.1% face-to-face, and 2.6% mixed provision. Remote support was valued by service users and staff for promoting openness, privacy, and reducing stigma, and was noted as removing access barriers and improving service availability. However, the absence of carbon monoxide monitoring in remote support raised accountability concerns. The trade-off in "quantity vs. quality" of quits was debated, as remote support reached more users but produced fewer carbon monoxide-validated quits. Primarily offering remote support could lead to substantial workloads, as staff often extend their roles to include social/mental health support, which was sometimes emotionally challenging. Offering service users a choice of support options was considered more important than the "cost-per-quit". Improved dissemination of information to support service users in understanding their options for support was suggested. CONCLUSIONS: The hybrid approach allows smoking cessation services to evaluate which groups benefit from remote, face-to-face, or mixed options and allocate resources accordingly. Providing choice, flexible provision, non-judgmental support, and clear information about available options could improve engagement and match support to individual needs, enhancing outcomes.
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Monóxido de Carbono , Pandemias , Humanos , Fumar , Fumar Tabaco , InglaterraRESUMO
OBJECTIVES: We tested whether generalized beliefs that the world is safe, abundant, pleasurable, and progressing (termed "primal world beliefs") are associated with several objective measures of privilege. METHODS: Three studies (N = 16,547) tested multiple relationships between indicators of privilege-including socioeconomic status, health, sex, and neighborhood safety-and relevant world beliefs, as well as researchers and laypeople's expectations of these relationships. Samples were mostly from the USA and included general population samples (Study 2) as well as focused samples of academic researchers (Study 1) and people who had experienced serious illness or trauma (Study 3). RESULTS: Studies 1-2 found mostly negligible relationships between world beliefs and indicators of privilege, which were invariably lower than researcher predictions (e.g., instead of the expected r = 0.33, neighborhood affluence correlated with Abundant world belief at r = 0.01). Study 3 found that people who had experienced serious illness (cancer, cystic fibrosis) only showed modest differences in beliefs from controls. CONCLUSIONS: While results do not preclude that some individuals' beliefs were meaningfully affected by life events, they imply that such changes are smaller or less uniform than widely believed and that knowing a person's demographic background may tell us relatively little about their beliefs (and vice versa).
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BACKGROUND: There is widespread recognition that creating a safety culture supports high-quality health care. However, the complex factors affecting cultural change interventions are not well understood. This study examines factors influencing the implementation of an intervention to promote professionalism and build a safety culture at an Australian hospital. METHODS: The study was completed midway into the three-year intervention and involved collecting qualitative data from two sources. First, face-to-face interviews were conducted pre- and mid-intervention with a purposely selected sample. Second, a survey with three open-ended questions was completed one year into the intervention by clinical and patient support staff. Data from interviews and survey questions were analyzed using a combination of inductive and deductive approaches. RESULTS: A total of 25 participants completed preintervention interviews, and 24 took part mid-intervention. Of the 2,047 staff who completed the survey (61% response rate), 59.1% of respondents answered at least one open-ended question. Multiple interrelated factors were identified as enhancing intervention implementation. These include sustaining a favorable implementation climate, leaders consistently demonstrating behaviors that support a safety culture, increasing compatibility of working conditions with intervention aims, building confidence in systems to address unprofessional behaviors, and responding to evolving needs. CONCLUSION: Strengthening safety culture remains an enduring challenge, but this study yields valuable insights into factors influencing implementation of a multifaceted behavior change intervention. The findings provide a basis for practical strategies that health care leaders seeking cultural improvements can employ to enhance the delivery of similar interventions and address potential impediments to success.
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Cultura Organizacional , Profissionalismo/normas , Gestão da Segurança/organização & administração , Adulto , Austrália , Comunicação , Feminino , Administração Hospitalar , Humanos , Capacitação em Serviço , Entrevistas como Assunto , Liderança , Masculino , Pessoa de Meia-Idade , Pesquisa Qualitativa , Qualidade da Assistência à Saúde , Gestão da Segurança/normas , Meio SocialRESUMO
Culturing bacteria and monitoring bacterial cell growth is a critical issue when dealing with patients who present with bacterial infections. One of the main challenges that arises is the time taken to identify the particular strain of bacteria and consequently, decide the correct treatment. In the majority of cases, broad spectrum antibiotics are used to target infections when a narrow spectrum drug would be more appropriate. The efficient monitoring of bacterial growth and potential antibiotic resistance is necessary to identify the best treatment options for patients. Minturising the reactions into microfluidic droplets offers a novel method to rapidy analyze bacteria. Microfluidics facilitates low volume reactions that provide a unique system where each droplet reaction acts as an individual bioreactor. Here, we designed and built a novel platform that allowed us to create and monitor E.coli microfluidic droplet cultures. Optical capacity was built in and measurements of bacterial cultures were captured facilitating the continuous monitoring of individual reactions. The capacity of the instrument was demonstrated by the application of treatments to both bacteria and drug resistant strains of bacteria. We were able to detect responses within one hour in the droplet cultures, demonstrating the capacity of this workflow to the culture and rapid characterization of bacterial strains.
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Antibacterianos/farmacologia , Resistência Microbiana a Medicamentos , Escherichia coli/efeitos dos fármacos , Dispositivos Lab-On-A-Chip , Microfluídica/métodos , Nefelometria e Turbidimetria/métodos , Ampicilina/farmacologia , Escherichia coli/crescimento & desenvolvimento , Canamicina/farmacologia , Testes de Sensibilidade Microbiana , Microfluídica/economia , Microfluídica/instrumentação , Nefelometria e Turbidimetria/economia , Nefelometria e Turbidimetria/instrumentação , Dispositivos ÓpticosRESUMO
BACKGROUND: Despite the many advantages of an aortic allograft valve (AAV) over a prosthetic aortic valve, its durability is suboptimal. The aims of the present study were to document characteristic features of AAV dysfunction and to investigate factors influencing the development of such dysfunction. METHODS AND RESULTS: A group of 570 patients (mean age, 48+/-16 years) with a cryopreserved AAV underwent a follow-up echocardiographic study (mean time after surgery, 6.8 years; range, 1.0 to 22.9 years). Significant AAV regurgitation was present in 14.7% of patients, and AAV stenosis was present in 3.2%. The root replacement subgroup had the smallest number of patients with significant AAV regurgitation (5.0%) compared with the subcoronary (23.0%) or the inclusion cylinder technique subgroup (14.7%). After 10 to 15 years after AAV replacement, grade > or =2 AAV dysfunction was present in 40% of patients in the subcoronary subgroup, but no significant dysfunction was observed in patients in the root replacement subgroup (P<0.001). Smaller host aortic annulus size in both subcoronary (coefficient, -0.145; P=0.013) and root replacement subgroups (coefficient, -0.249; P=0.011) was associated with more frequent AAV dysfunction (grade > or =2). In addition, significant AAV dysfunction was more frequent when patients were younger (coefficient, -0.020; P=0.015) in the subcoronary subgroup and the donor was older (coefficient, 0.054; P=0.019) in the root replacement subgroup. CONCLUSIONS: The present study indicates that the root replacement technique is associated with less frequent AAV degeneration. Our findings should help in establishing more strict selection criteria for surgical replacement procedure type and patient/donor factors for AAV replacement and, therefore, could lead to improve AAV longevity.
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Valva Aórtica/transplante , Criopreservação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Valva Aórtica/fisiopatologia , Estenose da Valva Aórtica/fisiopatologia , Estenose da Valva Aórtica/cirurgia , Criança , Pré-Escolar , Ecocardiografia , Feminino , Seguimentos , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Doadores de Tecidos , Transplante HomólogoRESUMO
BACKGROUND: Alveolar air leaks and broncho-pleural fistulae after thoracic surgical procedures contribute significantly to hospital morbidity and mortality. BioGlue has offered the thoracic surgeon an alternative to the products presently used to reduce the incidence of these complications. This retrospective study reviews our experience with this new adhesive. METHODS: Forty patients upon whom BioGlue was used were identified through operation records. Pre-, intra- and postoperative data were collected to establish use, indications and outcome. RESULTS: The predominant underlying pathology was malignancy. In 32 patients BioGlue was used during the primary procedure while in the remaining eight, persistent air- or lymph-leak led to a further procedure requiring the use of glue. The indications for BioGlue use were alveolar air leak (36), broncho-pleural fistula (2) and lymph leak (2). There was one death. In 35 out of 36 patients with alveolar air leak, BioGlue controlled the leak at the site of application. CONCLUSIONS: Our results in this particular patient group indicate that BioGlue is a reliable adjunct in the reduction of alveolar air leaks. Although further studies are necessary to establish the role of BioGlue in thoracic surgery in comparison to other sealants, these initial results are promising.
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Proteínas/uso terapêutico , Procedimentos Cirúrgicos Torácicos , Adesivos Teciduais/uso terapêutico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
BACKGROUND: The recent emergence of BioGlue Surgical Adhesive has widened the field of surgical adhesives for the cardiac surgeon. We believe the present series, in a wider spectrum of cardiac conditions, is the first larger scale evaluation of the use of this new adhesive. METHODS: BioGlue was used in 115 consecutive patients (90 male and 25 female, age range 5 days to 87 years) from September 9, 1998 to March 12, 2001. Preoperative, intraoperative, and postoperative data were examined to establish its use, indications, and outcomes in patients undergoing cardiac surgical procedures. RESULTS: The most common underlying pathologic conditions were aortic dissections (30 patients) and aortic aneurysms (39 patients). The procedures carried out were aortic root replacement (36 patients), aortic wall replacement (39), ascending aorta repair (2), coronary artery bypass grafting (28), valve procedures (11), ventricular aneurysm repair (6), repair of postinfarct ventricular septal defect (2), and correction of congenital conditions (13 patients). The indications for BioGlue use were hemostasis in 79 patients, tissue adherence in 21, and tissue strengthening in 30. The hospital mortality was 10.1% (11 patients). Only 1 patient required a late reoperation for dehiscence of a suture line with formation of a false aneurysm. The mean postoperative blood loss at 12 hours was 702 mL. Ten patients developed a cerebrovascular accident postoperatively, which was considered to be unrelated to the use of BioGlue. CONCLUSIONS: All surgeons in this study believed that BioGlue facilitated the operation. Future follow-up of patients is required to validate our early promising results and to assess the long-term outcome of patients treated with BioGlue.
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Procedimentos Cirúrgicos Cardíacos , Adesivos Teciduais , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Perda Sanguínea Cirúrgica , Procedimentos Cirúrgicos Cardíacos/mortalidade , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/mortalidade , Reoperação , Estudos RetrospectivosRESUMO
OBJECTIVE: To compare the cost effectiveness of recombinant human FSH (Gonal-F; Serono, Inc., Randolph, MA) and urinary FSH (Fertinex; Serono, Inc.) for ovarian stimulation during IVF with or without intracytoplasmic sperm injection for the treatment of infertility. DESIGN: Clinical decision analysis techniques (the Markov model) were used to model the direct medical costs per patient during assisted reproductive technology. MAIN OUTCOME MEASURE(S): Clinical and economic outcomes of two different ovarian stimulation protocols (recombinant human FSH or urinary FSH) during three treatment cycles were considered. RESULT(S): More ongoing pregnancies were achieved, with fewer stimulation cycles, after recombinant human FSH (Gonal-F) than after urinary FSH (Fertinex) (40,665 versus 37,890). In addition, recombinant human FSH was also found to be more cost effective per ongoing pregnancy. From a societal perspective, the mean cost per pregnancy was $40,688 for recombinant human FSH versus $47,096 for urinary FSH. From the insurers' perspective, the mean cost/pregnancy for recombinant human FSH was $28,481 versus $32,967 for urinary FSH. CONCLUSION(S): Recombinant human FSH (Gonal-F) is not only more efficient clinically than urinary FSH (Fertinex), but also more cost effective. This analysis illustrates the point that the economic effectiveness of a drug depends less on its acquisition costs and rather more on the clinical outcomes associated with its use.
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Fertilização in vitro/métodos , Hormônio Foliculoestimulante/uso terapêutico , Gravidez/estatística & dados numéricos , Injeções de Esperma Intracitoplásmicas/economia , Análise Custo-Benefício , Feminino , Fertilização in vitro/economia , Hormônio Foliculoestimulante/urina , Humanos , Infertilidade Masculina/terapia , Masculino , Cadeias de Markov , Proteínas Recombinantes/uso terapêutico , Estados UnidosRESUMO
BACKGROUND AND AIM OF THE STUDY: Results of valve rereplacement (reoperation) in 898 patients undergoing aortic valve replacement with cryopreserved homograft valves between 1975 and 1998 are reported. The study aim was to provide estimates of unconditional probability of valve reoperation and cumulative incidence function (actual risk) of reoperation. METHODS: Valves were implanted by subcoronary insertion (n = 500), inclusion cylinder (n = 46), and aortic root replacement (n = 352). Probability of reoperation was estimated by adopting a mixture model framework within which estimates were adjusted for two risk factors: patient age at initial replacement, and implantation technique. RESULTS: For a patient aged 50 years, the probability of reoperation in his/her lifetime was estimated as 44% and 56% for non-root and root replacement techniques, respectively. For a patient aged 70 years, estimated probability of reoperation was 16% and 25%, respectively. Given that a reoperation is required, patients with non-root replacement have a higher hazard rate than those with root replacement (hazards ratio = 1.4), indicating that non-root replacement patients tend to undergo reoperation earlier before death than root replacement patients. CONCLUSION: Younger patient age and root versus nonroot replacement are risk factors for reoperation. Valve durability is much less in younger patients, while root replacement patients appear more likely to live longer and hence are more likely to require reoperation.
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Valva Aórtica/transplante , Implante de Prótese de Valva Cardíaca , Reoperação , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Austrália/epidemiologia , Criança , Pré-Escolar , Seguimentos , Doenças das Valvas Cardíacas/mortalidade , Doenças das Valvas Cardíacas/cirurgia , Humanos , Incidência , Lactente , Pessoa de Meia-Idade , Probabilidade , Fatores de Risco , Análise de Sobrevida , Resultado do TratamentoRESUMO
BACKGROUND AND AIM OF THE STUDY: The association between aortic valve allograft dysfunction in patients with long-term follow up and human leukocyte class 2 antigen donor/recipient mismatch suggests that elements of the anti-donor immune response penetrate and damage the aortic valve allograft. An aortic valve allograft recipient cohort was studied to determine whether presence of recipient antibodies to donor human leukocyte class 1 or 2 antigen was associated with shorter time to aortic valve allograft dysfunction. METHODS: Both donor and recipient human leukocyte antigen (HLA) type, HLA antibody information and echocardiography data were available for 148 recipients of cryopreserved aortic valve allografts between 1986 and 1998. Structural deterioration of the aortic valve allograft was defined as at least moderate aortic stenosis or regurgitation by echocardiography. Recipient sera were assayed for anti-HLA (class 1 and 2) antibodies using three assays: complement-dependent cytotoxicity (CDC) on T- and B-lymphocyte panels (CDC PRA); flow cytometry using HLA-coated beads (Flow PRA); and an ELISA using HLA-coated microwells. The donor specificity of anti-class 1 and 2 HLA antibodies was determined on T- and B-cell panels using CDC. Associations between the results of the three assays and donor-specific class 1 and 2 antibodies and time to structural deterioration were analyzed using Kaplan-Meier curves of freedom from structural deterioration. Cox proportional-hazards were used to determine independent predictors of time to structural deterioration. RESULTS: Patients highly positive for HLA class 2 antibodies using an ELISA had a significant association (p = 0.007) with shorter time to aortic valve allograft structural deterioration using both a log rank test and Cox proportional-hazards analysis. Patients (n = 15) with donor-specific antibodies to class 2 antigen (DR antigens) had significantly more structural deterioration (p = 0.035) than those without specific antibodies. CONCLUSION: The association between aortic valve allograft structural deterioration and high titer human leukocyte class 2 antigen antibodies, a subset detected by ELISA adds further information about the link between HLA class 2 mismatch and structural deterioration. Further studies are needed to confirm the importance of class 2 antibodies on outcome, and to determine by which method these antibodies should be detected. Potential recipients with pre-existing antibodies of these specific types might be expected to sustain accelerated allograft damage.
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Valva Aórtica/transplante , Rejeição de Enxerto/imunologia , Doenças das Valvas Cardíacas/cirurgia , Antígenos de Histocompatibilidade Classe II/imunologia , Imunologia de Transplantes , Adolescente , Adulto , Idoso , Análise de Variância , Valva Aórtica/imunologia , Criança , Pré-Escolar , Estudos de Coortes , Criopreservação , Ensaio de Imunoadsorção Enzimática , Feminino , Seguimentos , Sobrevivência de Enxerto , Antígenos HLA/análise , Antígenos HLA-DR/análise , Antígenos de Histocompatibilidade Classe II/análise , Teste de Histocompatibilidade , Humanos , Masculino , Pessoa de Meia-Idade , Probabilidade , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Medição de Risco , Doadores de Tecidos , Transplante HomólogoRESUMO
Dead tissue, in the form of slough and necrosis, can, if present in a wound, delay healing and promote infection. Debridement describes any method by which such materials are removed and, as a consequence, the potential to achieve wound healing enhanced. In this article, the first of two, the author discusses the history of debridement, cell death, the nature of necrotic tissue and a variety of debridement techniques. All methods of debridement have associated risks and benefits and while this article examines its clinical application there are also legal and professional issues to consider particularly in relation to conservative sharp debridement. These issues will be addressed in the second article.
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Desbridamento/métodos , Ferimentos e Lesões/terapia , Anti-Infecciosos Locais/uso terapêutico , Apoptose , Bandagens , Boratos/uso terapêutico , Desbridamento/efeitos adversos , Desbridamento/enfermagem , Humanos , Peróxido de Hidrogênio/uso terapêutico , Necrose , Povidona-Iodo/uso terapêutico , Fatores de Risco , Hipoclorito de Sódio/uso terapêutico , Resultado do Tratamento , Cicatrização , Ferimentos e Lesões/etiologia , Ferimentos e Lesões/patologiaRESUMO
Deciding which product or technique to use in order to effect debridement involves more than a simple dressing choice. Patient preference, degree of risk, environmental factors, resources and possible contra indications/cautions must be taken into account before proceeding. The option of conservative sharp debridement is a valuable tool and is potentially of great benefit to many patients. Despite this it may be underused in primary care due to the perception that it is a high risk procedure.
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Desbridamento , Contraindicações , Desbridamento/ética , Desbridamento/legislação & jurisprudência , Tomada de Decisões , Acessibilidade aos Serviços de Saúde/legislação & jurisprudência , Humanos , Satisfação do Paciente/legislação & jurisprudência , Gestão de Riscos/legislação & jurisprudência , Ferimentos e Lesões/cirurgiaRESUMO
OBJECT: Many patients with myelomeningocele (MMC) develop hydrocephalus, and most will undergo CSF diversion. The goal of this retrospective study was to determine whether there was a change in the shunt rate over the 7 consecutive years of the study. The authors will also identify the criteria used to determine the need for shunt placement. METHODS: During a 7-year period, 73 patients underwent MMC closure at Arkansas Children's Hospital. The shunt rate for each year was calculated. Clinical characteristics were evaluated, including apneic and bradycardic spells, CSF leak, level of the MMC, head circumference, and rate of head growth. In addition, radiological images were reviewed, and the frontooccipital horn ratio (FOHR), ventricular index (VI), and thalamooccipital distance (TOD) were calculated. Comparisons were made between those patients who underwent shunt placement and those who did not. RESULTS: One patient was excluded due to death in the perinatal period. Of the 72 remaining patients, 54 (75%) underwent placement of a ventriculoperitoneal shunt. This rate did not change significantly over time. Between the cohorts with and without a shunt there was no significant difference in age, sex, or race. There was no significant difference in apneic episodes or bradycardic episodes. There was a statistically significant difference in fontanelle characteristics, head circumference at birth, and rate of head growth. Patients who required CSF diversion had a mean head growth of 0.32 cm/day compared with those who did not receive a shunt (0.13 cm/day; p < 0.05). All radiological parameters were found to be statistically significant. CONCLUSIONS: In this study, several classic indicators of hydrocephalus in the neonate were not found to be significantly associated with the need for CSF diversion. Fontanelle characteristics, head circumference at birth, and head growth velocity were associated with the need for shunt placement. Imaging information including the VI, TOD, and FOHR are statistically significant measures to evaluate prior to placement of a ventriculoperitoneal shunt. The optimal patient with MMC for CSF diversion will have full to tense fontanelle, increasing head circumference of more than 3 mm/day, and radiological evidence of an elevated VI, TOD, and/or FOHR.
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Cabeça/patologia , Hidrocefalia/cirurgia , Meningomielocele/complicações , Derivação Ventriculoperitoneal , Criança , Pré-Escolar , Feminino , Cabeça/crescimento & desenvolvimento , Humanos , Hidrocefalia/complicações , Lactente , Recém-Nascido , Masculino , Meningomielocele/cirurgia , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Resultado do TratamentoRESUMO
In the UK school system social remits - requiring schools to work towards improved social as well as educational outcomes for children - have become significant over the last decade. This study focuses upon the inter-professional issues in the running of one small-scale intervention involving parents and their babies based in schools in an urban setting in the UK. The programme, run over the school year 2007/08, provided a professional framework in which parents from the local community surrounding a school brought their babies into classroom settings to talk about aspects of baby care and development. This professional framework included classroom teachers, one senior cross-school education manager, family health visitors and one senior children's health nurse. Despite agreement about the benefits of the programme there were also clear differences of priority. This paper describes the different perceptions that each of these two sets of professionals - from health and from education - had of the programme, and highlights some critical perspectives that tended to come more from health professionals. It also maps out potential solutions which draw upon recent literature that is similarly focused upon inter-professional and inter-agency service delivery. In so doing it offers valuable insights to professionals working in inter-agency collaborations in schools.
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Desenvolvimento Infantil , Comportamento Cooperativo , Relações Pais-Filho , Instituições Acadêmicas , Adulto , Pré-Escolar , Grupos Focais , Humanos , Entrevistas como Assunto , Reino UnidoAssuntos
Rejeição de Enxerto/imunologia , Doenças das Valvas Cardíacas/cirurgia , Valvas Cardíacas/transplante , Imunologia de Transplantes , Adulto , Fatores Etários , Antígenos HLA/análise , Antígenos HLA/imunologia , Doenças das Valvas Cardíacas/imunologia , Humanos , Isoanticorpos/análise , Isoanticorpos/imunologia , Pessoa de Meia-Idade , Medição de Risco , Sensibilidade e Especificidade , Transplante Homólogo/imunologiaRESUMO
PURPOSE: Papilledema is considered one of the cardinal ophthalmologic signs of shunt failure. However, the prevalence of papilledema in children with shunt malfunction has not been systematically investigated. The purpose of this study is to determine the sensitivity of papilledema as a sign of shunt failure in children. METHODS: A prospective evaluation was undertaken of all children (n = 29; <19 years of age) with surgically confirmed shunt malfunction who were treated at Arkansas Children's Hospital between July 2007 and April 2008. Each child had a dilated fundus examination and/or RetCam photograph while under anesthesia immediately before shunt repair. The optic disk was evaluated for the presence of papilledema and pallor. Intracranial pressure was measured during surgical shunt repair at the discretion of the neurosurgeon. RESULTS: Twenty-nine patients had surgically confirmed shunt failure. Patient's age ranged from 36 days to 18 years, 8 months. Four patients (14%) had papilledema, and 1 patient had severe optic disk pallor. The remaining 24 patients had flat optic disks. Five patients had flat optic disks despite an intracranial pressure >/=300 mm H(2)O. CONCLUSIONS: Papilledema is not a sensitive sign of shunt failure. Even children with severe elevations in intracranial pressure from shunt malfunction may have flat optic disks. Therefore, physicians that evaluate children with shunts should be aware that a normal optic disk does not preclude shunt malfunction.
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Derivações do Líquido Cefalorraquidiano/efeitos adversos , Hipertensão Intracraniana/diagnóstico , Hipertensão Intracraniana/etiologia , Papiledema/diagnóstico , Papiledema/etiologia , Adolescente , Criança , Pré-Escolar , Falha de Equipamento , Feminino , Humanos , Hidrocefalia/cirurgia , Lactente , Masculino , Oftalmoscopia , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Sensibilidade e EspecificidadeRESUMO
INTRODUCTION: Antibodies to baker's yeast (mannan) have been widely used to aid in diagnosis of Crohn's disease. Recently, there has been interest in antibodies against a flagellin from Clostridium coccoides subphylum. We hypothesized that reactivity with these antigens is a surrogate marker for a generalized increased IgG response against intestinal microbiota in Crohn's disease. METHODS: We compared the diagnostic utility of IgG antibodies against flagellin and mannan with two complex surface antigen preparations, one derived from B. vulgatus (Bv), the other from over 20 common mucosa-associated microbiota, a multibacterial membrane preparation (MBP). IgG antibodies were measured in sera from two age- and sex-matched populations: 120 Crohn's patients (CD) and 160 gastroenterology controls (CON) comprising 40 ulcerative colitis (UC) and 120 non-IBD patients. RESULTS: IgG was elevated against all antigen preparations in Crohn's but statistical analysis of receiver operator characteristic (ROC) plots showed that IgG against the complex antigen preparations MBP and Bv had better diagnostic accuracy to distinguish the two populations (CD and CON) than IgG against mannan (P < or = 0.01) or flagellin (P < or = 0.04). Concentrations of antibody reactive with distinct individual antigens correlated weakly. DISCUSSION: The findings support our hypothesis that measurement of IgG reactivity against individual antigens gives an indication of a generalized increased IgG response against individual intestinal microbiota in Crohn's, rather than measuring specific immune responses important for pathogenesis. The data are consistent with either a mucosal defect that facilitates increased exposure to microbial antigens or an altered immune response, both of which could occur due to known genetic and molecular defects in Crohn's disease.
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Antígenos de Bactérias/imunologia , Doença de Crohn/diagnóstico , Doença de Crohn/imunologia , Flagelina/imunologia , Imunoglobulina G/sangue , Intestinos/microbiologia , Mananas/imunologia , Adulto , Feminino , Humanos , MasculinoRESUMO
BACKGROUND: This truly stentless porcine valve is composite, without Dacron, and implanted supra-annularly. Ten-year analysis with magnetic resonance imaging is presented. METHODS: From 1992 to 2002, 402 patients (mean 73.5 years) had aortic valve replacement. Associated procedures were required in 252 patients (63%). Serial echoes provided 1340 studies. Clinical follow-up was 100%. Magnetic resonance imaging focused on aortic annulus extensibility. RESULTS: The 30-day mortality was 0.99% (4 deaths). Morbidity comprised thromboembolism (40 patients including 18 patients with permanent strokes); endocarditis (9 patients); and reoperation (9 patients [periprosthetic leak, 2; endocarditis, 5; technical needle damage, 1; and structural degeneration, 1]). Of 402 valves more than 10 years, five valves were explanted, one only for structural failure. Except for endocarditis (2 patients), no late deaths (69 patients, 1.5 months to 5.7 years) were valve related. Echocardiography demonstrated low gradients with good orifice areas, excellent ventricular regression (p = 0.0001 preoperative and postoperative comparisons) and late incompetence (mild in 45 patients and moderate in 9 patients). No living patient has severe incompetence. Magnetic resonance imaging demonstrated the annulus 'expanding and relaxing' throughout the cardiac cycle, the mean increase in cross-sectional area being 37%, resembling normal aortic root dynamics. CONCLUSIONS: Elderly patients received this hemodynamically acceptable valve with its simple, supra-annular implantation and satisfactory mid-term morbid-free lifestyle to 10 years maximum follow-up. With only one structural failure, restoration of valve annular extensibility may have a favorable influence on long-term durability.
Assuntos
Valva Aórtica/cirurgia , Bioprótese , Próteses Valvulares Cardíacas , Análise Atuarial , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Seguimentos , Próteses Valvulares Cardíacas/efeitos adversos , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Fatores de TempoRESUMO
Objetivo: Analisar o estado atual e a justificativa para o uso continuado das próteses aórticas sem suporte, dando enfoque aos resultados clínicos com a prótese porcina composta CryoLife-O'Brien (CLOB). Casuística e Métodos: Entre dezembro de 1992 e fevereiro de 2000, 307 pacientes foram submetidos à troca da valva aórtica por uma prótese CLOB. A idade média dos pacientes era de 73 anos (59-89 anos), sendo 16 por cento acima de 80 anos. Todos os pacientes foram analisados clínica e ecocardiograficamente no pós-operatório com 6 dias, 6 meses, 12 meses e anualmente. Resultados: A mortalidade hospitalar foi 1,3 por cento (4 casos näo relacionados à troca valvar). A mortalidade tardia foi 9,2 por cento (28 pacientes); dos quais somente 2 (endocardite tardia) eram prótese-relacionados. Morbidade incluiu: 2 (0,6 por cento) casos de acidente vascular cerebral perioperatório, 6 (1,9 por cento) "leaks" perivalvares, 6 (1,9 por cento) endocardites e 1 (0,3 por cento) deterioraçäo estrutural. Reoperaçäo foi necessária em 6 (1,9 por cento) pacientes: 3 por endocardite, 2 por "leak" perivalvar e 1 por deterioraçäo estrutural. Os ecocardiogramas seriados demonstraram um gradiente médio de 7mmHg, com uma baixa incidência de incompetência trivial pelo doppler, e regressäo significativa da hipertrofia ventricular esquerda (p=0,05). Conclusäo: As próteses sem suporte têm apresentado excelentes resultados a curto e médio prazos. Entretanto, vigilância rigorosa é necessária para determinar a durabilidade aos 10-12 anos, período em que as valvas porcinas com suporte começam a demonstrar deterioraçäo estrutural