Detalhe da pesquisa
1.
Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.
Bioorg Med Chem Lett
; 96: 129518, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37838344
2.
Addressing the Reciprocal Crosstalk between the AR and the PI3K/AKT/mTOR Signaling Pathways for Prostate Cancer Treatment.
Int J Mol Sci
; 24(3)2023 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36768610
3.
Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs).
Chem Soc Rev
; 50(3): 1480-1494, 2021 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33346298
4.
Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Bioorg Med Chem Lett
; 39: 127904, 2021 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33684441
5.
C-H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity.
Angew Chem Int Ed Engl
; 57(33): 10737-10741, 2018 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-29761878
6.
Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.
J Med Chem
; 2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38748070
7.
Trends in Molecular Properties, Bioavailability, and Permeability across the Bayer Compound Collection.
J Med Chem
; 66(4): 2347-2360, 2023 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36752336
8.
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
J Med Chem
; 66(4): 2918-2945, 2023 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36727211
9.
Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: towards the synthesis of functionalized amide building blocks.
Chemistry
; 18(51): 16292-6, 2012 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23154863
10.
Drug discovery for epigenetics targets.
Drug Discov Today
; 27(4): 1088-1098, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34728375
11.
Pyridin-2-yl guanidine derivatives: conformational control induced by intramolecular hydrogen-bonding interactions.
J Org Chem
; 76(22): 9216-27, 2011 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21977964
12.
Targeting PRC2 for the treatment of cancer: an updated patent review (2016 - 2020).
Expert Opin Ther Pat
; 31(2): 119-135, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-33103538
13.
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
J Med Chem
; 64(23): 17146-17183, 2021 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34807608
14.
Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives.
Org Biomol Chem
; 8(24): 5558-67, 2010 Dec 21.
Artigo
Inglês
| MEDLINE | ID: mdl-20949223
15.
The Next Generation of Pattern Recognition Receptor Agonists: Improving Response Rates in Cancer Immunotherapy.
Curr Med Chem
; 27(34): 5654-5674, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-31250749
16.
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Chem Sci
; 11(39): 10792-10801, 2020 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34094333
17.
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
J Med Chem
; 63(23): 14530-14559, 2020 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32910656
18.
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.
Cell Chem Biol
; 27(1): 41-46.e17, 2020 01 16.
Artigo
Inglês
| MEDLINE | ID: mdl-31786184
19.
Rapid Identification of Novel Allosteric PRC2 Inhibitors.
ACS Chem Biol
; 14(10): 2134-2140, 2019 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-31525019
20.
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2ß protein-protein interaction.
Chem Sci
; 10(19): 5056-5063, 2019 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31183056