Detalhe da pesquisa
1.
Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes.
Drug Metab Dispos
; 52(6): 565-573, 2024 May 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38565303
2.
Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate.
Drug Metab Dispos
; 52(5): 323-336, 2024 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38360917
3.
Projections of Drug-Drug Interactions Caused by Time-Dependent Inhibitors of Cytochrome P450 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6 Using In Vitro Data in Static and Dynamic Models.
Drug Metab Dispos
; 2024 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38408867
4.
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance.
Drug Metab Dispos
; 51(6): 647-656, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36973000
5.
The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration.
Drug Metab Dispos
; 51(10): 1419-1427, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37429728
6.
Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1.
Drug Metab Dispos
; 50(4): 413-421, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35042700
7.
Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping.
Drug Metab Dispos
; 50(3): 249-257, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34903590
8.
An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach.
Drug Metab Dispos
; 2022 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35777845
9.
Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach.
Drug Metab Dispos
; 2022 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35777846
10.
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Drug Metab Dispos
; 50(5): 576-590, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35153195
11.
Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes.
Drug Metab Dispos
; 49(10): 947-960, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34326140
12.
Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition.
Drug Metab Dispos
; 49(9): 822-832, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34183376
13.
Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay.
Protein Expr Purif
; 177: 105749, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32911062
14.
Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants.
Drug Metab Dispos
; 49(6): 442-450, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33811106
15.
Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.
Chem Res Toxicol
; 33(1): 223-238, 2020 01 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31532188
16.
Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model.
Chem Res Toxicol
; 33(1): 211-222, 2020 01 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31538772
17.
Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
Drug Metab Dispos
; 47(8): 874-882, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31182423
18.
Emerging Models of Drug Metabolism, Transporters, and Toxicity.
Drug Metab Dispos
; 46(11): 1556-1561, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30333205
19.
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds.
Drug Metab Dispos
; 46(11): 1466-1477, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30115648
20.
Biosynthesis and Identification of Metabolites of Maraviroc and Their Use in Experiments to Delineate the Relative Contributions of Cytochrome P4503A4 versus 3A5.
Drug Metab Dispos
; 46(5): 493-502, 2018 May.
Artigo
Inglês
| MEDLINE | ID: mdl-29475834