Detalhe da pesquisa
1.
Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.
Chembiochem
; 22(10): 1769-1774, 2021 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33491295
2.
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells.
Science
; 384(6694): eadk5864, 2024 Apr 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38662832
3.
Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.
J Org Chem
; 78(6): 2661-9, 2013 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23438191
4.
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
J Med Chem
; 66(5): 3195-3211, 2023 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36802610
5.
Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
ACS Med Chem Lett
; 12(10): 1585-1588, 2021 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34676040
6.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34663813
7.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34726479
8.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32935104
9.
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
J Med Chem
; 61(10): 4476-4504, 2018 05 24.
Artigo
Inglês
| MEDLINE | ID: mdl-29613789
10.
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J Med Chem
; 60(1): 386-402, 2017 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27997172
11.
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
J Med Chem
; 58(6): 2678-702, 2015 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25695670
12.
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
J Med Chem
; 58(7): 3223-52, 2015 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25781223
13.
Spirocyclic sulfamides as ß-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
J Med Chem
; 55(21): 9224-39, 2012 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-22984865
14.
Combined directed ortho metalation-halogen dance (HD) synthetic strategies. HD-anionic ortho fries rearrangement and double HD sequences.
Org Lett
; 12(10): 2198-201, 2010 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-20397661
15.
Directed ortho metalation-boronation and Suzuki-Miyaura cross coupling of pyridine derivatives: a one-pot protocol to substituted azabiaryls.
J Org Chem
; 72(5): 1588-94, 2007 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-17284076