Detalhe da pesquisa
1.
Rapid Synthesis of Chiral Figure-Eight Macrocycles Using a Preorganized Natural Product-Based Scaffold.
Angew Chem Int Ed Engl
; 63(9): e202318548, 2024 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38169344
2.
Synthetic Modulation of an Unstable Dehydrosecodine-type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X-ray Crystallographic Observation.
Angew Chem Int Ed Engl
; 62(32): e202305122, 2023 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37263970
3.
Regiocontrolled Dimerization of Densely Functionalized 1,6-Dihydropyridines for the Biomimetic Synthesis of a Halicyclamine-type Scaffold by Preventing Disproportionation.
J Org Chem
; 87(9): 5938-5951, 2022 05 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35420034
4.
Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
Bioorg Med Chem
; 30: 115949, 2021 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33360196
5.
Total synthesis of alkaloids using both chemical and biochemical methods.
Nat Prod Rep
; 37(8): 1098-1121, 2020 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32141467
6.
Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins.
J Org Chem
; 85(15): 9694-9712, 2020 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32610901
7.
A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.
Org Biomol Chem
; 18(28): 5339-5343, 2020 07 22.
Artigo
Inglês
| MEDLINE | ID: mdl-32618320
8.
Stereodivergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Antiproliferative Activity.
Chembiochem
; 20(10): 1273-1281, 2019 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30638296
9.
Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability.
Bioorg Med Chem Lett
; 29(14): 1807-1811, 2019 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31109792
10.
Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3.
J Am Chem Soc
; 140(34): 10705-10709, 2018 08 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30113836
11.
Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-Symmetric Bispyrrolidinoindoline Manifold.
J Org Chem
; 83(24): 15284-15296, 2018 Dec 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30489080
12.
Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly.
Org Biomol Chem
; 16(48): 9305-9313, 2018 12 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30387482
13.
Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents.
Bioorg Med Chem
; 25(11): 2851-2855, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28314509
14.
Biomimetic Assembly Lines Producing Natural Product Analogs: Strategies from a Versatile Manifold to Skeletally Diverse Scaffolds.
Chem Rec
; 16(2): 652-66, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26828424
15.
Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization.
Org Biomol Chem
; 13(21): 5955-63, 2015 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-25927165
16.
Nickel-catalyzed dimerization of pyrrolidinoindoline scaffolds: systematic access to chimonanthines, folicanthines and (+)-WIN 64821.
Org Biomol Chem
; 12(2): 298-306, 2014 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-24217772
17.
Synthesis of a Halicyclamine-Type Macrocyclic Scaffold via Biomimetic Transannular Cyclization.
Org Lett
; 25(20): 3596-3601, 2023 May 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37042667
18.
Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis.
J Am Chem Soc
; 134(17): 7246-9, 2012 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-22506807
19.
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
Nat Chem Biol
; 6(6): 408-10, 2010 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-20453862
20.
Hg(OTf)(2)-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions.
Org Biomol Chem
; 10(21): 4236-42, 2012 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-22522575