Detalhe da pesquisa
1.
Development of STING degrader with double covalent ligands.
Bioorg Med Chem Lett
; 102: 129677, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38408510
2.
Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation.
Bioorg Med Chem Lett
; 107: 129778, 2024 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38702019
3.
Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.
Bioorg Chem
; 145: 107204, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38377822
4.
Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures.
Chem Pharm Bull (Tokyo)
; 72(2): 149-154, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38296556
5.
Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor.
Bioconjug Chem
; 34(10): 1780-1788, 2023 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37736001
6.
Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands.
Bioorg Med Chem
; 86: 117293, 2023 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37126968
7.
Development of a potent small-molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation.
Cancer Sci
; 113(8): 2828-2838, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-35579105
8.
Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication.
J Pharmacol Sci
; 149(3): 81-84, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-35641031
9.
Development of ciclesonide analogues that block SARS-CoV-2 RNA replication.
Bioorg Med Chem Lett
; 43: 128052, 2021 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33887440
10.
Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine.
J Pept Sci
; 27(12): e3360, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34164880
11.
Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation.
Int J Mol Sci
; 22(16)2021 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34445478
12.
The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21.
J Biol Chem
; 294(44): 16429-16439, 2019 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31533987
13.
Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.
Bioorg Med Chem
; 28(15): 115595, 2020 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32631565
14.
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.
J Biol Chem
; 293(18): 6776-6790, 2018 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29545311
15.
SNIPERs-Hijacking IAP activity to induce protein degradation.
Drug Discov Today Technol
; 31: 35-42, 2019 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-31200857
16.
Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc.
Biol Pharm Bull
; 42(3): 481-488, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30828079
17.
Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein.
Chem Pharm Bull (Tokyo)
; 67(3): 165-172, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30827996
18.
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
Chem Pharm Bull (Tokyo)
; 67(3): 203-209, 2019 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30369550
19.
Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation.
Molecules
; 24(17)2019 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31461933
20.
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).
J Biol Chem
; 292(11): 4556-4570, 2017 03 17.
Artigo
Inglês
| MEDLINE | ID: mdl-28154167