Detalhe da pesquisa
1.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem J
; 460(2): 211-22, 2014 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24593284
2.
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
Bioorg Med Chem Lett
; 23(3): 767-72, 2013 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23265881
3.
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Proc Natl Acad Sci U S A
; 107(34): 15240-5, 2010 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-20696890
4.
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Nat Struct Mol Biol
; 11(12): 1192-7, 2004 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-15543157
5.
Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.
Bioorg Med Chem
; 17(20): 7113-25, 2009 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19783444
6.
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett
; 10(1): 80-85, 2019 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30655951
7.
Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.
Bioorg Med Chem
; 16(9): 4883-907, 2008 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18394907
8.
Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).
Protein Sci
; 16(12): 2657-66, 2007 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-18029420
9.
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
J Med Chem
; 50(21): 5090-102, 2007 Oct 18.
Artigo
Inglês
| MEDLINE | ID: mdl-17880056
10.
A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii.
J Mol Biol
; 353(5): 1055-68, 2005 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-16225889
11.
The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment.
Recent Results Cancer Res
; 172: 155-67, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17607940
12.
Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
J Med Chem
; 54(12): 4219-33, 2011 Jun 23.
Artigo
Inglês
| MEDLINE | ID: mdl-21557540
13.
The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.
Acta Crystallogr D Biol Crystallogr
; 64(Pt 3): 321-30, 2008 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-18323627
14.
Structural asymmetry and intersubunit communication in muscle creatine kinase.
Acta Crystallogr D Biol Crystallogr
; 63(Pt 3): 381-9, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17327675
15.
Inhibitors of Bcr-abl... breaking new ground again.
Nat Chem Biol
; 2(2): 63-4, 2006 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-16421581