Detalhe da pesquisa
1.
hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.
Proteins
; 80(1): 206-20, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22038794
2.
N-(4-Substituted-benzoyl)-N'-(ß-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorg Med Chem
; 20(5): 1801-16, 2012 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22325154
3.
Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined.
Proteins
; 79(3): 703-19, 2011 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21287607
4.
Halogen-substituted (C-ß-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase.
Bioorg Med Chem
; 19(17): 5125-36, 2011 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21821421
5.
The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.
Structure
; 17(1): 117-27, 2009 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-19141288
6.
The binding of ß-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.
Bioorg Med Chem
; 18(22): 7911-22, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20947361
7.
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorg Med Chem
; 17(20): 7368-80, 2009 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19781947
8.
Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyranosyl urea binding.
Proteins
; 71(3): 1307-23, 2008 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18041758
9.
New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase.
Chembiochem
; 9(2): 253-60, 2008 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-18188862
10.
Structural basis for the carbohydrate recognition of the Sclerotium rolfsii lectin.
J Mol Biol
; 368(4): 1145-61, 2007 May 11.
Artigo
Inglês
| MEDLINE | ID: mdl-17391699
11.
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
J Med Chem
; 51(12): 3540-54, 2008 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-18517260
12.
Advances in glycogen phosphorylase inhibitor design.
Curr Opin Investig Drugs
; 9(4): 379-95, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18393105
13.
Recognition of ribonuclease A by 3'-5'-pyrophosphate-linked dinucleotide inhibitors: a molecular dynamics/continuum electrostatics analysis.
Biophys J
; 92(5): 1659-72, 2007 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17142283
14.
FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase.
Protein Sci
; 16(8): 1773-82, 2007 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-17600143
15.
Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
J Med Chem
; 49(19): 5687-701, 2006 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-16970395
16.
Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.
Protein Sci
; 14(4): 873-88, 2005 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-15741340
17.
Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.
Protein Sci
; 14(7): 1760-71, 2005 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-15987904
18.
Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution.
Biochim Biophys Acta
; 1647(1-2): 325-32, 2003 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-12686153
19.
Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
Proteins
; 61(4): 966-83, 2005 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16222658
20.
The binding of IMP to ribonuclease A.
FEBS J
; 272(15): 3988-4001, 2005 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-16045769