Evaluation of nutritional status using body fat, physiological and biochemical parameters in some Nigerian women.

Some nutritional parameters were investigated in 62 healthy Nigerian female subjects of low socio-economic status. The percentage body fat (% BF) and some biochemical parameters, High and Low Density Lipoprotein Cholesterol (HDL-C and LDL-C), Total Plasma Cholesterol (TC), Triglyceride (TG), Uric Acid (UA), Urinary Creatinine (U-Cr), Creatinine in plasma (P-Cr) and Creatinine clearance (Cr-CI), were evaluated. Also determined were the Body Mass Index (BMI), Packed Cell Volume, Systolic and Diastolic Blood Pressure (BP-I, BP-2), various skin-fold measurements and body circumferences. Reference values were then established for these various parameters and the correlation between the various variables determined. When the subjects were stratified into four groups (underweight, normal, overweight, and obese) based on their BMI, significant differences (ANOVA, p < 0.05) were observed in LDL-C, Cr-CI, BP-I, as well as 10 out of the 13 anthropometric parameters. These differences could possibly provide diagnostic/prognostic insight for the four groups and the many important diseases associated with them. The hip circumference, in particular, has such a high correlation with both BMI and % BF that it is being suggested as a substitute for these two important parameters in Nigerian women of low socio-economic background.

Awareness and breast cancer risk factors: perception and screening practices among females in a tertiary institution in Southwest Nigeria.

AIMS AND OBJECTIVES: this study is aimed at assessing the practices of breast cancer screening and risk perception of women of reproductive age group in a tertiary institution in Osun state. SUBJECTS AND METHODS: It was a descriptive cross sectional study carried out at the Federal polytechnic, Ede. A total of 393 eligible respondents recruited using a stratified random sampling technique, were interviewed using semi-structured questionnaire after obtaining a verbal consent from them. RESULTS: About two thirds (67.9%) of those who had heard of breast cancer knew that there were screening methods available. Of these 91.6% knew breast self examination, 93.2% knew clinical breast examination and only a third 32.8% knew mammography as a screening method. About half of respondents who were aware of breast cancer practice breast self examination. Only 28 (7.6%) of the respondents had ever visited any clinic for breast cancer screening, and 85.7% (24) of the visit was for clinical breast examination while mammography was rarely done (14.3%). Eighty one per cent of those who were aware of breast cancer believed that screening had a role to play. CONCLUSION: The study shows that though awareness of breast cancer among respondents was good, the practice of breast cancer screening was poor among the respondents and even worse with screening with mammography. A major recommendation is that initiatives to reduce morbidity and mortality due to breast cancer among young females in the southwest Nigeria should include education on risk factors, early signs and methods of screening for breast cancer.

Determination of trace elements status of Nigerians with sickle cell anaemia using INAA and PIXE.

The clinical application of trace elements in the management of Sickle Cell Anaemia (SCA) has not become standard recommended practice despite decades of research. A major reason for this is the ambivalence in published results as to the relative importance of some of these elements in the disease. An attempt has been made in this work to correct some of the various factors that could contribute to such inconsistencies. Results from separate investigations carried out on Nigerian subjects by our group, using both INAA and PIXE methods have been holistically evaluated and compared. Trace and minor elements were determined in wholeblood, erythrocytes, plasma, headhair and nail obtained from SCA patients in steady state and compared with identical samples from normal controls. Twelve elements were determined in blood while 20 and 30 elements were analysed in nail and hair samples respectively from the total 225 subjects. The results indicate a general mild zinc deficiency, more serious for males, in Nigerian SCA patients. It is clear that the elements Na, K, Rb and Br play key roles in maintaining homeostasis in the steady-state SCA patients. Possible gender influence in the utilization of K, Br and Fe in SCA is also suggested.

Study of trace elements in blood of cancer patients by proton-induced X-ray emission (PIXE) analysis.

Proton-induced X-ray emission (PIXE) analysis was employed to determine the concentrations of six elements in the plasma and erythrocytes of 18 cancer subjects (15 males and 3 females) with neoplastic disorders and in 70 controls (35 males and 35 females). It was found that the concentrations of Br, K, and Zn were significantly elevated in the erythrocytes of the cancer subjects compared to the controls, whereas the concentration of Fe was significantly depressed, but with no difference observed in the concentration of Ca. In the plasma, the concentrations of Br, Cu, Ca, and K were significantly elevated, whereas the concentrations of Fe and Zn were found to be significantly depressed compared to the controls.

Elemental concentrations in nigerians with affective disorders using proton-induced X-ray emission.

The concentrations of a number of elements are determined in the plasma and erythrocytes of 21 Nigerians (11 females, 10 males) with symptomatic affective disorders (11 depressives, 10 manics) and in 40 normal controls using proton-induced X-ray emission (PIXE) analysis. The study shows that there is significant elevation of plasma K and Zn, as well as the erythrocyte S in the patients relative to the controls. The plasma and erythrocyte Cu, and the erythrocyte P, Ca, Fe, and Zn are significantly lower in the patients compared to the controls. However, the plasma levels of Ca, S, Fe, and Br are similar in both the patients and the controls. Similarly, the concentrations of K, Br, and Rb show no significant difference in the erythrocytes of patients and controls.

Elemental composition of head hair and fingernails of some Nigerian subjects.

In this article, we present the elemental concentrations determined by INAA for 30 elements measured in some or all head hair samples of 100 Nigerian subjects and 20 elements in the fingernails of some of the same subjects. Measurements of the skewness of the distribution of each element in both tissues confirm previous reports that many tend toward a log-normal distribution. Thus, their concentrations in the tissues may not be under any homeostatic control. The ranges of elemental concentrations together with the medians, and the arithmetic and geometric means, with their respective standard deviations are presented and compared with literature values for other populations. Correlations between elements detected in hair are also sought.

Correlations between trace element levels in head hair and blood components of Nigerian subjects.

Elemental concentrations in head hair and blood (whole-blood, erythrocytes and plasma) of 28 Nigerian subjects were determined using instrumental neutron activation analysis (INAA) and proton-induced X-ray emission (PIXE) techniques. Correlations found between different elements in hair and blood are reported. Hair levels of both zinc and chlorine were found to be significantly correlated with their levels in erythrocytes.

Baseline levels of elemental concentrations in whole blood, plasma, and erythrocytes of Nigerian subjects.

In this pioneering effort on Nigerians, the arithmetic means, ranges, and standard deviations for the concentrations of the 13 elements, Br, Ca, Cl, Cu, Fe, K, Na, P, Pb, Rb, S, Se, and Zn, detected in freeze-dried whole blood, erythrocytes, and plasma of 120 subjects drawn from different geographical regions of Nigeria are reported. Elemental analyses have been carried out largely using instrumental neuron activation analysis (INAA) with both proton-induced X-ray emission (PIXE) and graphite furnace atomic absorption spectrometry (AAS) serving as complementary techniques. Our values, compared with similar data from other parts of the world, show a general good agreement. Values in male and female subjects are compared. Correlations between different elements are also noted.