The association between perceived social functioning and heart rate variability is mediated by subclinical depressive symptomatology and moderated by gender.

Chronic loneliness and low perceived social support have been recognized as risk factors for both mental and cardiovascular disorders. It has been proposed that their link to psychophysiological problems may involve changes in parasympathetic activity. However, the exact underlying psychopathological mechanisms and the moderating effects of gender are still not thoroughly examined. Thus, the present study investigated associations between perceived social functioning and resting vagal tone in the context of potential cognitive and subclinical mediators and gender differences. Three hundred twenty-five young adults (aged 18-35, 180 women) underwent an electrocardiogram measurement of 6-minute resting heart rate variability (HRV). They also completed questionnaires assessing loneliness, perceived social support, social cognitive biases, depressive and social anxiety symptoms, and general mental health. In men, HRV was significantly and negatively associated with poorer perceived social functioning, depressive symptoms, and self-reported social cognitive biases, while in women, there was a quadratic link between HRV and depressive symptoms and HRV and general mental health. Moderated mediation analysis revealed that depressive symptoms fully mediated the relationship between perceived social functioning and HRV in men. The results suggest that decreased resting vagal tone in lonely individuals is linked to depressive symptomatology rather than to specific social cognitive biases and that this association is significant only in men.

Using ERPs to explore the impact of affective distraction on working memory stages in schizophrenia.

Research on individuals with schizophrenia (SCZ) shows a variety of emotional and cognitive deficits. We examined the hypothesis that ineffective emotional interference control may impact working memory (WM) performance by disrupting information encoding, maintenance, or retrieval in SCZ. Twenty-eight SCZ and 28 matched healthy controls (HC) performed the visual and verbal delayed-matching-to-sample task (DMST) with trials preceded by negative and nonemotional visual distractors. Event-Related Potentials associated with affective stimuli processing (Late Positive Potential-LPP) and WM-encoding (target-P3), maintenance (Negative Slow Wave-NSW), and retrieval (probe-P3) were analyzed. Patients showed overall worse DMST accuracy than HC. Emotional distraction negatively impacted accuracy during the verbal DMST in both groups combined. Both groups also displayed similar LPP modulation during the presentation of emotional distractors. HC showed enhanced NSW after presentation of a negative distraction, whereas this did not occur in SCZ. Comparable effects of emotional distraction were found for WM-encoding and retrieval in both groups. While emotional and neutral stimuli differentially impacted WM-maintenance on the neural level in HC, we did not observe this effect in SCZ, even though both groups showed similar behavioral and neurophysiological reactions to affective stimuli. Deficits in inhibitory mechanisms in SCZ may be responsible for this effect and may have particular relevance for WM-maintenance difficulties.

Affective and Cognitive Verbal Theory of Mind in Schizophrenia: Results From a Novel Paradigm.

OBJECTIVES: Impairments of Theory of Mind (ToM) have been repeatedly demonstrated in patients with schizophrenia (SCZ). However, only a handful of studies have explored deficits in affective and cognitive subcomponents of ToM. Thus, this study aims to examine affective and cognitive ToM abilities in SCZ by using a novel, verbal paradigm. METHODS: Twenty-four SCZ and 22 healthy comparison subjects (HC) completed a battery of tasks, which consisted of: (i) Brief Cognitive Assessment Tool for Schizophrenia (B-CATS), (ii) three well-established tasks measuring social cognitive abilities, and (iii) original tasks which assess ability to infer cognitive and affective mental states based on everyday verbal social interactions. RESULTS: In line with previous findings, SCZ were outperformed by HC in all tasks. However, the interaction effect of the group and the task showed that cognitive (as opposed to affective) ToM was more profoundly impaired in patients with SCZ. CONCLUSIONS: It is proposed that in SCZ group cognitive ToM is more impaired as it involves more effortful reflective processes, while affective ToM, which is more automatic and based on reflexive processes, may differentiate patients from healthy comparison subjects to a lesser extent. (JINS, 2018, 24, 305-309).

Social Perception in Mesial Temporal Lobe Epilepsy: Interpreting Social Information From Moving Shapes and Biological Motion.

Dysfunction in the understanding of social signals has been reported in persons with epilepsy, which may partially explain lower levels of life satisfaction in this patient population. Extensive assessment is necessary, particularly when the mesial temporal lobe, responsible for emotion processing, is affected. The authors examined multiple levels of social perception in patients with mesial temporal lobe epilepsy (MTLE), including judgments of point-light motion displays of human communicative interactions (Communicative Interactions Database-5 Alternative Forced Choice format) and theory-of-mind processes evaluated using geometric shapes (Frith-Happé animations [FHA]). This case-control study included MTLE patients with anterior temporal lobectomies (ATL+) (N=19), MTLE patients without lobectomies (ATL-) (N=21), and healthy controls (HCs) (N=20). Both groups of MTLE patients were less efficient in recognizing goal-directed and mentalizing interactions of FHA compared with HC subjects. The ATL+ group attributed emotions to FHA less accurately than HC subjects. Both the ATL- and ATL+ groups classified individual point-light animations more often as communicative than the HC group. ATL+ patients were also less efficient in interpreting point-light animations in terms of individual actions than the HC group. The number of years of epilepsy duration was inversely correlated with recognition of FHA interactions. The mean number of seizures was inversely correlated with the interaction identification in point-light stimuli. Patients with MTLE, irrespective of surgical treatment, present impaired social perception in domains assessed with abstract moving shapes or nonabstract biological motion. This impairment may be the basis of problems faced by patients reporting difficulties in understanding the intentions and feelings of other individuals.

Gaze matters! The effect of gaze direction on emotional enhancement of memory for faces in patients with mesial temporal lobe epilepsy.

PURPOSE: The aim of the study was to examine if gaze and emotional expression, both highly self-relevant social signals, affect the recollection accuracy of perceived faces in patients with mesial temporal lobe epilepsy (MTLE). METHODS: Forty patients with MTLE (twenty-one without surgery and nineteen after anterior temporal lobectomy) as well as twenty healthy controls (HC) took part in the study. We used a set of 64 facial stimuli: 32 neutral and 32 emotional displays (16 fearful; 16 angry) from well-established affective stimuli databases. Half of the faces in each condition had eyes directed straight and half - away from the observer. Participants performed a gender identification task, and then, after a 45-minute delay were asked to identify the previously seen stimuli, presented among a new set of photos. RESULTS: Increased automatic learning of angry and fearful compared to neutral expressions was found in HC. There was no emotional enhancement of memory in MTLE but an increased learning for faces with averted than direct gaze. CONCLUSION: Our results expand on previous research by demonstrating that emotion expression and gaze direction can affect memory of faces. The study supports the hypothesis that healthy individuals and patients with temporal lobe abnormalities present different patterns of emotional gazes processing. The potential consequences of altered emotional gaze processing and social cognition impairments need to be further investigated to improve the quality of life of patients with MTLE.

[Facial emotion recognition in patients with recurrent depressive disorder and patients with schizophrenia]. / Zdolnosc rozpoznawania emocji u chorych z zaburzeniami depresyjnymi i u chorych na schizofreni.

UNLABELLED: The ability to recognize emotion on the basis of facial expressions is an important component of emotional intelligence. Correct identification of facial mimics is a crucial element of nonverbal communication and it facilitates the processes of social cognition. The impairment of identification of facial emotion can contribute to i.a. deterioration in social functioning. Numerous empirical studies have proven that facial emotion recognition is disordered in schizophrenia and depression. The aim of the study was to compare the ability to recognize facial emotions between patients with schizophrenia, patients with recurrent depressive disorder and healthy controls. Moreover, the relation between scale of the impairment and severity of clinical symptoms was examined. MATERIAL AND METHODS: Participants of the study were divided into three groups: patients diagnosed with schizophrenia (n = 36), patients diagnosed with recurrent depressive disorder (n = 36) and healthy controls (n = 36). Facial emotion recognition was assessed in each group by using Emotional Intelligence Scale (SIE-T). Furthermore, the correlation between the performance in SIE-T and severity of clinical symptoms, assessed with Hamilton Depression Dating Scale and the Positive and Negative Syndrome Scale (PANSS) was tested. RESULTS: Patients diagnosed with schizophrenia were significantly impaired in SIE-T when compared with patients with depression and healthy controls. No statistically significant differences were observed between two latter groups. However, a correlation between performance and severity of depressive symptoms, as well as a trend towards a correlation between severity of positive symptoms and performance in SIE-T were observed. CONCLUSIONS: Patients with schizophrenia displayed the most severe deficits in facial emotion recognition of all three groups, and their impairment was independent from severity of symptoms. However, in depression deficits are related to severity of depression symptoms. The impairment of facial emotion recognition can significantly affect patients' social functioning.

[Planning disorders in men with schizophrenia and in men with localized frontal lobe lesions]. / Zaburzenia planowania u mezczyzn chorych na schizofrenie lub z ogniskowymi uszkodzeniami platów czolowych.

AIM: Planning disorders have been observed in people with frontal lobe lesions for many decades. There's also growing body of evidence of frontal dysfunction in people with schizophrenia. The aim of this study is to compare the planning abilities in men with schizophrenia, men with localized frontal lobe lesions and healthy men. METHOD: A sample of 90 men participated in the study. They were divided into three groups: men with schizophrenia (n = 30), men with localized frontal lobe lesions (n = 30) and healthy men (n = 30) as a control group. Planning abilities were assessed with a clinical trial based on Tower of London task. RESULTS: Significant differences in ToL measures were found between controls and men with schizophrenia (Trials solved: p < 0.01; Trials solved perfectly: p < 0.05; Execution time: p < 0.001) and between controls and men with frontal lobe lesions (Trials solved: p < 0.001; Thinking time: p < 0.05; Execution time: p < 0.001). No significant differences were found between schizophrenia and frontal lobe lesion groups. CONCLUSIONS: Similar deficits in planning and solving problems, which require planning, may be observed in men with schizophrenia and men with frontal lobe lesions. In both groups time spent on thinking is less effective than in healthy men. Not only quantitative, but also qualitative assessment should be carried when examining patients' performance on Tower of London task.

Can we dissociate hypervigilance to social threats from altered perceptual decision-making processes in lonely individuals? An exploration with Drift Diffusion Modeling and event-related potentials.

It has been hypothesized that lonely individuals demonstrate hypervigilance toward social threats. However, recent studies have raised doubts about the reliability of tasks commonly used to measure attentional biases toward threats. Two alternative approaches have been suggested to overcome the limitations of traditional analysis of attentional bias. First, the neurophysiological indicators of orienting to threats were shown to have superior psychometric characteristics compared to overt measures of behavioral performance. The second approach involves utilizing computational modeling to isolate latent components corresponding to specific cognitive mechanisms from observable data. To test the usefulness of these approaches in loneliness research, we analyzed behavioral and electroencephalographic (EEG) data from 26 lonely and 26 non-lonely participants who performed a dot-probe task using a computational modeling approach. We applied the Drift Diffusion Model (DDM) and extracted N2pc-an event-related potential that serves as an indicator of spatial attention. No evidence for social threat hypervigilance has been found in DDM parameters nor in N2pc characteristics in the current study. However, we did observe decreased drift rate and increased variability in drift rate between trials within the lonely group, indicating reduced efficiency in perceptual decision-making among lonely individuals. These effects were not detected using standard behavioral measures used in the dot-probe paradigm. Given that DDM indicators were sensitive to differences in perceptual discrimination between the two groups, even when no overt differences were found in standard behavioral measures, it may be postulated that computational approaches offer a more comprehensive understanding of cognitive processes.

Threatened by others or by everything? The effects of momentary and trait loneliness on daily appraisals of social company and being alone in young adults.

Theoretical accounts of loneliness suggest that it may lead to psychopathological consequences by increasing the perception of social threat. However, it is unclear whether the real-life effects of both trait and state loneliness are specific to social situations. To answer this question, two experience sampling studies were conducted with prestratified samples of young adults (18-35) with moderate (Study 1, N = 64) or low and high (Study 2, N = 103) levels of loneliness. Participants were asked to report their emotional states and appraisals of social and nonsocial situations. Multilevel modelling of momentary and time-lagged associations revealed that trait loneliness was associated with less positive (Study 1) and more negative (Study 2) company appraisals. Importantly, in Study 2, trait loneliness was also related to less positive and more negative appraisals of being alone. Momentary loneliness was related to less positive and more negative appraisals of both types and predicted negative social appraisals over time in both studies. In Study 2, time-lagged interaction effects on social appraisals were found between the two levels. The results suggest that in highly lonely individuals, both levels of loneliness may lead to a general negativity bias and have a synergistic effect.

Communicative intentions automatically hold attention - evidence from event-related potentials.

Numerous studies show that social cues are processed preferentially by the human visual system and that perception of communicative intentions, particularly those self-directed, attracts and biases attention. However, it is still unclear when in the temporal hierarchy of visual processing communicative cues exert impact on perception and whether their effects are automatic or volitional. Therefore, in the present study, we used electroencephalography (EEG) to investigate the pattern of neural activity associated with processing communicative and individual gestures. Participants (N = 24) were shown animations depicting either biological (BM) or scrambled motion (SM) and were asked to categorize them accordingly. Additionally, BM depicted either communicative or individual actions. The results showed that while early components (N1, N2) are sensitive to differences between BM and SM, the differentiation of neural activity related to the type of action performed by point-light agent (individuals vs. communicative) is observed only for late components such as posterior late positive potential (>500 ms). The findings of the current study show that even in the absence of any top-down effects, social intentions produce long-lasting attentional effects at the later stages of stimuli processing.

Two Means Together? Effects of Response Bias and Sensitivity on Communicative Action Detection.

Numerous lines of research suggest that communicative dyadic actions elicit preferential processing and more accurate detection compared to similar but individual actions. However, it is unclear whether the presence of the second agent provides additional cues that allow for more accurate discriminability between communicative and individual intentions or whether it lowers the threshold for perceiving third-party encounters as interactive. We performed a series of studies comparing the recognition of communicative actions from single and dyadic displays in healthy individuals. A decreased response threshold for communicative actions was observed for dyadic vs. single-agent animations across all three studies, providing evidence for the dyadic communicative bias. Furthermore, consistent with the facilitated recognition hypothesis, congruent response to a communicative gesture increased the ability to accurately interpret the actions. In line with dual-process theory, we propose that both mechanisms may be perceived as complementary rather than competitive and affect different stages of stimuli processing.

Climate change, vaccines, GMO: The N400 effect as a marker of attitudes toward scientific issues.

While the psychological predictors of antiscience beliefs have been extensively studied, neural underpinnings of the antiscience beliefs have received relatively little interest. The aim of the current study is to investigate whether attitudes towards the scientific issues are reflected in the N400 potential. Thirty-one individuals were asked to judge whether six different issues presented as primes (vaccines, medicines, nuclear energy, solar energy, genetically-modified organisms (GMO), natural farming) are well-described by ten positive and ten negative target words. EEG was recorded during the task. Furthermore, participants were asked to rate their own expertise in each of the six topics. Both positive and negative target words related to GMO elicited larger N400, than targets associated with vaccines and natural farming. The results of the current study show that N400 may be an indicator of the ambiguous attitude toward scientific issues.

Does the TPJ fit it all? Representational similarity analysis of different forms of mentalizing.

Mentalizing is the key socio-cognitive ability. Its heterogeneous structure may result from a variety of forms of mental state inference, which may be based on lower-level processing of cues encoded in the observable behavior of others, or rather involve higher-level computations aimed at understanding another person's perspective. Here we aimed to investigate the representational content of the brain regions engaged in mentalizing. To this end, 61 healthy adults took part in an fMRI study. We explored ROI activity patterns associated with five well-recognized ToM tasks that induce either decoding of mental states from motion kinematics or belief-reasoning. By using multivariate representational similarity analysis, we examined whether these examples of lower- and higher-level forms of social inference induced common or distinct patterns of brain activity. Distinct patterns of brain activity related to decoding of mental states from motion kinematics and belief-reasoning were found in lTPJp and the left IFG, but not the rTPJp. This may indicate that rTPJp supports a general mechanism for the representation of mental states. The divergent patterns of activation in lTPJp and frontal areas likely reflect differences in the degree of involvement of cognitive functions which support the basic mentalizing processes engaged by the two task groups.

Brief induction of loneliness decreases vagal regulation during social information processing.

Perceived social isolation, or loneliness, has been repeatedly linked to numerous adverse health outcomes. Much effort has been directed towards elucidating the mechanisms underlying its effects on the cardiovascular system, which may explain the deleterious effects on morbidity and mortality. It has been previously suggested that perceived social isolation can impair effective parasympathetic regulation and physiological adjustment to the demands of the social environment. Thus, the present study aimed at investigating the causal impact of an induction of loneliness on vagal activity during social stimuli processing. In the study, participants (N = 119) were led to anticipate either a future filled with satisfying relationships (Future Belong) or a lonely life (Future Alone). Then, they were asked to complete an implicit emotion regulation task while their cardiovascular activity was recorded. In the Future Belong group, a pattern of vagal suppression was observed between the resting period and task completion, which was followed by vagal recovery during the post-task resting period. However, in the Future Alone group, a change from the baseline HRV was observed only at the beginning of the task, but not during its consecutive stages. Moreover, in participants who believed in the given FA feedback, the initial vagal suppression was absent. These findings provide evidence that even a brief induction of loneliness can result in a blunted vagal suppression during social information processing. It can be hypothesized that the lack of the ability to regulate vagal activity while processing social cues may potentially underlie problems with social engagement and self-control.

Detecting formal thought disorder by deep contextualized word representations.

Computational linguistics has enabled the introduction of objective tools that measure some of the symptoms of schizophrenia, including the coherence of speech associated with formal thought disorder (FTD). Our goal was to investigate whether neural network based utterance embeddings are more accurate in detecting FTD than models based on individual indicators. The present research used a comprehensive Embeddings from Language Models (ELMo) approach to represent interviews with patients suffering from schizophrenia (N=35) and with healthy people (N=35). We compared its results to the approach described by Bedi et al. (2015), referred to here as the coherence model. Evaluations were also performed by a clinician using the Scale for the Assessment of Thought, Language and Communication (TLC). Using all six TLC questions the ELMo obtained an accuracy of 80% in distinguishing patients from healthy people. Previously used coherence models were less accurate at 70%. The classifying clinician was accurate 74% of the time. Our analysis shows that both ELMo and TLC are sensitive to the symptoms of disorganization in patients. In this study methods using text representations from language models were more accurate than those based solely on the assessment of FTD, and can be used as measures of disordered language that complement human clinical ratings.

Social Perception and Interaction Database-A Novel Tool to Study Social Cognitive Processes With Point-Light Displays.

Introduction: The ability to detect and interpret social interactions (SI) is one of the crucial skills enabling people to operate in the social world. Multiple lines of evidence converge to indicate the preferential processing of SI when compared to the individual actions of multiple agents, even if the actions were visually degraded to minimalistic point-light displays (PLDs). Here, we present a novel PLD dataset (Social Perception and Interaction Database; SoPID) that may be used for studying multiple levels of social information processing. Methods: During a motion-capture session, two pairs of actors were asked to perform a wide range of 3-second actions, including: (1) neutral, gesture-based communicative interactions (COM); (2) emotional exchanges (Happy/Angry); (3) synchronous interactive physical activity of actors (SYNC); and (4) independent actions of agents, either object-related (ORA) or non-object related (NORA). An interface that allows single/dyadic PLD stimuli to be presented from either the second person (action aimed toward the viewer) or third person (observation of actions presented toward other agents) perspective was implemented on the basis on the recorded actions. Two validation studies (each with 20 healthy individuals) were then performed to establish the recognizability of the SoPID vignettes. Results: The first study showed a ceiling level accuracy for discrimination of communicative vs. individual actions (93% ± 5%) and high accuracy for interpreting specific types of actions (85 ± 4%) from the SoPID. In the second study, a robust effect of scrambling on the recognizability of SoPID stimuli was observed in an independent sample of healthy individuals. Discussion: These results suggest that the SoPID may be effectively used to examine processes associated with communicative interactions and intentions processing. The database can be accessed via the Open Science Framework (https://osf.io/dcht8/).

Polish version of the Hinting Task - pilot study with patients with schizophrenia. / Polska wersja Testu Wskazówek - badanie pilotazowe u pacjentów ze schizofrenia.

OBJECTIVES: The main goal of the study was an adaptation and validation of the Hinting Task to Polish language. The Hinting Task is the main instrument used to assess theory of mind deficits in individuals with schizophrenia. METHODS: Two groups were compared in the course of the study: individuals with schizophrenia and people without a history of mental and neurological disorders. Psychometric properties of the instrument were analysed. Between-group difference in the mean scores of the Hinting Task was also calculated. Additionally, in the clinical group, the correlation of the severity of psychopathological symptoms with the result of the Hinting Task was also assessed. RESULTS: Results indicated satisfactory psychometric properties (internal consistency, inter-rater reliability and external validity) sufficient for between-group comparisons for research purposes. The presented test highly distinguished two assessed groups: individuals with schizophrenia and healthy controls. Contrary to the expectations, in the clinical group scores in the Hinting Task did not correlate with the severity of psychopathological symptoms. CONCLUSIONS: Polish translation of the Hinting Task has psychometric properties appropriate for the research setting. Usefulness of the Hinting Task in other clinical groups should be addressed in future research.

Safe but Lonely? Loneliness, Anxiety, and Depression Symptoms and COVID-19.

BACKGROUND: The COVID-19 pandemic has led governments worldwide to implement unprecedented response strategies. While crucial to limiting the spread of the virus, "social distancing" may lead to severe psychological consequences, especially in lonely individuals. METHODS: We used cross-sectional (n = 380) and longitudinal (n = 74) designs to investigate the links between loneliness, anxiety, and depression symptoms (ADS) and COVID-19 risk perception and affective response in young adults who implemented social distancing during the first 2 weeks of the state of epidemic threat in Poland. RESULTS: Loneliness was correlated with ADS and with affective response to COVID-19's threat to health. However, increased worry about the social isolation and heightened risk perception for financial problems was observed in lonelier individuals. The cross-lagged influence of the initial affective response to COVID-19 on subsequent levels of loneliness was also found. CONCLUSION: The reciprocal connections between loneliness and COVID-19 response may be of crucial importance for ADS during the COVID-19 crisis.

Mental Well-Being During Pandemic: The Role of Cognitive Biases and Emotion Regulation Strategies in Risk Perception and Affective Response to COVID-19.

Both cognitive appraisals of risks associated with the specific disease and affective response to crisis situations have been shown to shape an individual response to pandemics. COVID-19 pandemic and measures introduced to contain it present an unparalleled challenge to mental well-being worldwide. Here, we examine the relationship between self-reported cognitive biases (CB) and emotion regulation skills (ER), COVID-19 risk perception and affective response, and mental well-being (MWB). Five Hundred and Eleven individuals completed General Health Questionnaire, Emotion Regulation Questionnaire, Davos Assessment of Cognitive Biases Scale (DACOBS) as well as scales measuring COVID-19 risk perception and affective response during the initial days of the epidemic in Poland. We used path and bootstrapping analyses to examine the hypothesis that CB may shape MWB during COVID-19 pandemic both directly and indirectly by (i) decreasing ER capacity and (ii) by increasing COVID-19 risk perception and affective response. Negative effect of CB and positive effect of ER via cognitive reappraisal on MWB were observed in participants. Furthermore, in line with our hypothesis, we observed indirect effects of CB via increased COVID-19 risk perception and affective response and decreased use of reappraisal strategy, which all, in turn, were related to MWB. Finally, we found an indirect effect of CB on MWB through double mediation of suppression strategies and COVID-19 affective response. Results of the current study suggest that CB, which have been shown to be linked to a variety of mental health symptoms in non-clinical populations, may exacerbate the impact of the COVID-19 pandemic on mental health outcomes.

The second agent effect: Interpersonal predictive coding in people with schizophrenia.

Interpersonal predictive coding (IPC) enables one to use the information conveyed by the communicative action of one agent to predict the response of another agent. IPC relies both on explicit reflective processes (processing of communicative intentions) and automatic reflexive processes (motor resonance). Predictive coding deficits may underlie positive symptoms in people with schizophrenia (SCZ), yet IPC has not been analyzed in SCZ. Thirty-nine SCZ and 22 controls (HC) completed a simultaneous masking detection task, during which they observed either communicative (Com) or individual (Ind) actions of agent A and had to report the presence of the agent B, who was shown in half of the trials. In line with previous findings, detection criterion was lowered after Com as compared to Ind, suggesting a higher tendency to report the presence of a second agent after observing agent A's communicative gestures . Surprisingly, this effect was found to a similar extent in both groups. Communicative criterion was linked to mentalizing abilities, but not to symptoms in SCZ. Finding that SCZ show similar IPC as HC adds to the previous evidence that reflexive processes may be relatively intact in patients. Furthermore, the level of reflective processes may be crucial for patients' social functioning.