Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients.

We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients. We observed a statistically significant decrease of MCP-1/CCL2, MIP-1ß/CCL4, IL-7, and IL-2 at the time of study completion. In contrast, the serum levels of TNF-α were remarkably elevated. Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects. These data are an important contribution for the upcoming Xemys clinical trials.

The experience of disproportionate supplies of COVID-19 vaccines to Africa: the need for Africa to decolonize its public health response.

The recent outbreak of COVID-19 resulted in high fatality rates globally and huge socio-economic consequences. Vaccine development was considered as the most effective and fastest means to reduce the risks associated with the disease. All hands were on deck for effective vaccine development which resulted in several countries including African countries participating in the vaccine solidarity trial. At the heat of the pandemic in 2021, Africa with a population of 1.4 billion had 134.5 million supplies of COVID-19 vaccines. The United States in contrast with a population of 332 million had over 375 million doses of the vaccine. This was one of the factors that hindered most African countries from meeting up with the World Health Organization (WHO) target of 40% fully vaccinated individuals by December 2021. Even in some African countries where there were early and good supplies, there was vaccine wastage due to near to expire vaccines supplied to such countries which resulted in misconception and rejection of the vaccines among the public. This paper discussed the politics of COVID-19 vaccine production and distribution with its effects on Africa using documentary analysis. The paper also suggests strategic bold steps needed to be taken by African countries to decolonize public health response within the continent in preparation for future pandemics.

Predictive influence of personality traits on retirement anxiety among universities staff in Osun State, Nigeria.

BACKGROUND: Retirement anxiety may occur in retirement-eligible staff, and their reaction may depend on their personality traits. This study examined the predictive influence of five-factor personality traits on retirement anxiety among non-academic staff in some selected universities in Osun State, Nigeria. MATERIALS AND METHODS: The study utilized a multistage sampling technique. Two self-administered instruments, Redeemer's University Retirement Anxiety Scale and Mini-International Personality Item Pool were completed by 463 non-academic staff in five selected universities in Osun State, Nigeria. Descriptive statistics (frequency and percentages) and inferential statistics (hierarchical regression, two-sample t-test, and one-way ANOVA) were used to analyze data. RESULTS: The study found a high prevalence rate of retirement anxiety (85.1%) among university staff in Nigeria. In all, 13%, 16%, and 12.5% of the participants showed high levels of retirement anxiety dimensions (personal obligation, financial planning, and social detachment), respectively. Sociodemographic and personality traits jointly accounted for statistically significant (16%, 29%, and 22%) changes in personal obligation (R2 =0.16, P <.01), financial planning (R2 =0.29, P <.01), and social detachment (R2 =.22, P <.01), respectively. Personality traits (extraversion, agreeableness, conscientiousness, and neuroticism) and socio-demographic variables (age, educational level, job tenure, and job status) jointly contributed to the prediction of retirement anxiety dimensions (obligation concerns, financial planning, and social detachment). CONCLUSION: The findings highlighted the need for psychosocial interventions targeting the at-risk population was highlighted.