Antiviral and immunological activity of zinc and possible role in COVID-19.

Zn deficiency compromises its biological functions, its effect on the immune system and its antiviral activity, increasing vulnerability to infectious diseases. This narrative review aims at presenting and discussing functional aspects and possible mechanisms involved in the potential role of Zn in the immune response and antiviral activity for coronavirus infectious disease-19 (COVID-19) prevention and control. The searches were conducted in PubMed and Science Direct databases, using clinical trials, experimental studies in animals and humans, case-control studies, case series, letters to the editor, and review articles published in English, without restrictions on year of publication. Search approach was based on using the terms: 'zinc', 'COVID-19', 'antiviral agents', 'immunologic factors' and 'respiratory tract infections'. Literature shows the importance of Zn as an essential mineral immunomodulator with relevant antiviral activity in the body. Thus, although there is still a scarcity of studies evaluating Zn supplementation in patients with COVID-19, the results on the topic show the necessity of controlling Zn mineral deficiency, as well as maintaining its homoeostasis in the body in order to strengthen the immune system and improve the prevention of highly complex viral infections, such as that of the COVID-19.

Prevalence of metabolic syndrome and its components in Brazilian adolescents: a systematic review and meta-analysis.

OBJECTIVE: To determine the prevalence of metabolic syndrome (MS) and its components among Brazilian adolescents. DATA SOURCE: Databases, such as LILACS, MEDLINE, and SciELO, were searched for original cross-sectional studies published between 2010 and 2021. The inclusion criteria were determined based on the mnemonic CoCoPop - Condition, Context, and Population: studies determining the prevalence of MS and its components (condition) in the general population of Brazilian adolescents, female and male (population), enrolled in public or private schools in rural or urban areas (context). Reviews, editorials, and articles that did not directly relate to the prevalence of MS or that included non-adolescent age groups or groups with specific health conditions (obesity/overweight and others) were excluded. DATA SYNTHESIS: A total of 15 studies, including 43,227 adolescents, were identified. MS prevalence (95% confidence interval [95%CI]) was 2.9% (2.65-3.18) and 2.4% (1.90-2.90) (p<0.001) in males and females, respectively, by using the International Diabetes Federation (IDF) criteria. There was a significant difference in MS prevalence among Brazilian regions (Q=24.7; p<0.001). The lowest MS prevalence (95%CI) was determined for North Region of Brazil, 1.8% (1.52-2.13), and the highest for Northeast Region of Brazil, 2.9% (2.62-3.23). Regarding MS components, a higher prevalence (95%CI) was found for low high-density lipoprotein (HDL), 22.1% (12.49-36.17), followed by abdominal obesity, 11.0% (8.05-14.94), and arterial hypertension, 10.3% (7.84-13.48). CONCLUSIONS: This study allowed the determination of the prevalence of MS and the MS components in Brazilian adolescents, highlighting relevant aspects to be addressed on public health management.

Expression of metalloproteinases 2 and 9 and plasma zinc concentrations in women with fibroadenoma.

OBJECTIVE: This study aims to investigate the association between the immunohistochemical expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and plasma zinc in women with fibroadenoma. METHODS: This cross-sectional study included 37 premenopausal women with fibroadenoma. Waist circumference and body mass index of the participants were measured. Plasma zinc concentrations were determined using atomic flame absorption spectrophotometry. Fragments of breast tissue were fixed and incubated with primary mouse monoclonal antibodies (monoclonal antibodies matrix metalloproteinase -2 -507 and monoclonal antibodies matrix metalloproteinase -9-439). Semi-quantitative analysis of matrix metalloproteinase-2 and matrix metalloproteinase-9 immunoreactivity was performed. Spearman's test and Friedman's test were used for statistical analyses. The p<0.05 were considered statistically significant. RESULTS: The average age of the participants was 32.81±9.51 years. The body mass index and waist circumference values were within the normal range. The mean plasma zinc concentration was 42.73±13.84 µg/dL, with 94.6% inadequacy. A statistically significant difference was found between the positive expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 (p=0.0184). There was no significant correlation between the matrix metalloproteinase expression and the plasma zinc levels. CONCLUSIONS: Women with fibroadenoma had hypozincemia and positive expression of metalloproteinases.

Prevalence of metabolic syndrome and its components in Brazilian adolescents: a systematic review and meta-analysis / Prevalência da síndrome metabólica e seus componentes em adolescentes brasileiros: uma revisão sistemática e metanálise

Abstract Objective: To determine the prevalence of metabolic syndrome (MS) and its components among Brazilian adolescents. Data source: Databases, such as LILACS, MEDLINE, and SciELO, were searched for original cross-sectional studies published between 2010 and 2021. The inclusion criteria were determined based on the mnemonic CoCoPop — Condition, Context, and Population: studies determining the prevalence of MS and its components (condition) in the general population of Brazilian adolescents, female and male (population), enrolled in public or private schools in rural or urban areas (context). Reviews, editorials, and articles that did not directly relate to the prevalence of MS or that included non-adolescent age groups or groups with specific health conditions (obesity/overweight and others) were excluded. Data synthesis: A total of 15 studies, including 43,227 adolescents, were identified. MS prevalence (95% confidence interval [95%CI]) was 2.9% (2.65-3.18) and 2.4% (1.90-2.90) (p<0.001) in males and females, respectively, by using the International Diabetes Federation (IDF) criteria. There was a significant difference in MS prevalence among Brazilian regions (Q=24.7; p<0.001). The lowest MS prevalence (95%CI) was determined for North Region of Brazil, 1.8% (1.52-2.13), and the highest for Northeast Region of Brazil, 2.9% (2.62-3.23). Regarding MS components, a higher prevalence (95%CI) was found for low high-density lipoprotein (HDL), 22.1% (12.49-36.17), followed by abdominal obesity, 11.0% (8.05-14.94), and arterial hypertension, 10.3% (7.84-13.48). Conclusions: This study allowed the determination of the prevalence of MS and the MS components in Brazilian adolescents, highlighting relevant aspects to be addressed on public health management.

RESUMO Objetivo: Determinar a prevalência da síndrome metabólica (SM) e seus componentes em adolescentes brasileiros. Fontes de dados: Realizaram-se buscas nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs), Medical Literature Analysis and Retrieval System Online (Medline) e Scientific Electronic Library Online (SciELO) por estudos transversais originais publicados entre 2010 e 2021. Os critérios de inclusão foram determinados pelo Mnemônico CoCoPop — Condição, Contexto e População: estudos que determinam a prevalência de SM e seus componentes (condição) na população geral de adolescentes brasileiros, feminino e masculino (população), matriculados em escolas públicas ou privadas em áreas rurais ou urbanas (contexto). Revisões, editoriais, artigos não relacionados com a prevalência de SM ou que incluíssem grupos etários não adolescentes ou com condições de saúde específicas (obesidade/sobrepeso e outros) foram excluídos. Síntese dos dados: Quinze estudos, com 43.227 adolescentes, foram identificados. A prevalência de SM (intervalo de confiança — IC95%) no sexo masculino foi de 2,9% (2,65-3,18) e no feminino foi de 2,4% (1,90-2,90) (p<0,001), pelos critérios da Federação Internacional de Diabetes (IDF). Houve diferença significativa na prevalência de SM entre regiões brasileiras (Q=24,7; p<0,001). A menor prevalência de SM (IC95%) foi encontrada em região Norte, com 1,8% (1,52-2,13), e a maior na região Nordeste, com 2,9% (2,62-3,23). Em relação aos componentes da SM, maior prevalência (IC95%) foi encontrada para lipoproteína de baixa densidade (HDL) baixa (22,1%, 12,49-36,17), seguida de obesidade abdominal (11,0%, 8,05-14,94) e hipertensão arterial (10,3%, 7,84-13,48). Conclusões: Este estudo permitiu determinar a prevalência da SM e seus componentes em adolescentes brasileiros, destacando aspectos relevantes a serem abordados na gestão da saúde pública.

Hypomagnesemia and its relation with chronic low-grade inflammation in obesity.

INTRODUCTION:: The accumulation of visceral fat in obesity is associated with excessive production of proinflammatory adipokines, which contributes to low-grade chronic inflammation state. Moreover, the literature has shown that mineral deficiency, in particular of magnesium, has important role in the pathogenesis of this metabolic disorder with relevant clinical repercussions. OBJECTIVE:: To bring updated information about the participation of hypomagnesemia in the manifestation of low-grade chronic inflammation in obese individuals. METHOD:: Articles published in PubMed, SciELO, LILACS and ScienceDirect, using the following keywords: "obesity," "magnesium" and "low grade inflammation." RESULTS:: Scientific evidence suggests that magnesium deficiency favors the manifestation of low-grade chronic inflammation in obese subjects. CONCLUSION:: From literature data, it is evident the participation of magnesium through biochemical and metabolic reactions in protecting against this metabolic disorder present in obesity.

Zinc and metalloproteinases 2 and 9: What is their relation with breast cancer?

Zinc is the catalytic component of proteins that regulate responses to DNA damage, intracellular signaling enzymes, and matrix metalloproteinases, which are important proteins in carcinogenesis. The objective of this review is to bring current information on the participation of zinc and matrix metalloproteinases types 2 and 9 in mechanisms involved in the pathogenesis of breast cancer. We conducted a literature review, in consultation with the PubMed, Lilacs, and Scielo databases. The zinc and cysteine residues are structural elements shared by all members of the family of matrix metalloproteinases, and these proteins appear to be involved in the propagation of various types of neoplasms, including breast cancer. Moreover, transported zinc is likely to be used for the metalation of the catalytic domain of the newly synthesized metalloproteinases before the latter are secreted. Accordingly, increase in zinc concentrations in cellular compartments and the reduction of this trace element in the blood of patients with breast cancer appear to alter the activity of metalloproteinases 2 and 9, contributing to the occurrence of malignancy. Thus, it is necessary to carry out further studies with a view to clarify the role of zinc and metalloproteinases 2 and 9 in the pathogenesis of breast cancer.

Expression of metalloproteinases 2 and 9 and plasma zinc concentrations in women with fibroadenoma

SUMMARY OBJECTIVE: This study aims to investigate the association between the immunohistochemical expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and plasma zinc in women with fibroadenoma. METHODS: This cross-sectional study included 37 premenopausal women with fibroadenoma. Waist circumference and body mass index of the participants were measured. Plasma zinc concentrations were determined using atomic flame absorption spectrophotometry. Fragments of breast tissue were fixed and incubated with primary mouse monoclonal antibodies (monoclonal antibodies matrix metalloproteinase -2 -507 and monoclonal antibodies matrix metalloproteinase -9-439). Semi-quantitative analysis of matrix metalloproteinase-2 and matrix metalloproteinase-9 immunoreactivity was performed. Spearman's test and Friedman's test were used for statistical analyses. The p<0.05 were considered statistically significant. RESULTS: The average age of the participants was 32.81±9.51 years. The body mass index and waist circumference values were within the normal range. The mean plasma zinc concentration was 42.73±13.84 µg/dL, with 94.6% inadequacy. A statistically significant difference was found between the positive expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 (p=0.0184). There was no significant correlation between the matrix metalloproteinase expression and the plasma zinc levels. CONCLUSIONS: Women with fibroadenoma had hypozincemia and positive expression of metalloproteinases.

Association between calcium/magnesium ratio and insulin resistance in women with obesity and normal-weight women

ABSTRACT The aim of this study was to evaluate the association between the calcium/magnesium (Ca/Mg) ratio and insulin resistance in women with obesity and normal-weight women. This was a cross-sectional study with 128 women (62 women with obesity and 66 normal-weight women). We measured dietary minerals intake and analyzed magnesium and calcium biomarkers. Ca/Mg ratio in diet, plasma and urine were calculated. We have evaluated glycemic parameters. Women with obesity had low dietary magnesium, reduced plasma and erythrocyte magnesium concentrations, and elevated urinary magnesium excretion. Plasma calcium concentration was lower and urinary calcium excretion was higher in patients with obesity than in the normal-weight group. Dietary magnesium and calcium intake per kilogram of body weight per day was lower in obese women than in the control group. Ca/Mg ratio in plasma and urine were elevated in women with obesity. We found a significant correlation among magnesium biomarkers and calcium parameters. Ca/Mg ratio seems to be associated with insulin resistance in obese women.

RESUMEN El objetivo de este estudio fue evaluar la asociación entre la relación Ca/Mg y la resistencia a la insulina en mujeres con obesidad y en mujeres con peso normal. El diseño del estudio fue transversal y participaron 128 mujeres (62 mujeres con obesidad y 66 mujeres con peso normal). Se analizó la ingesta de minerales en la dieta y se realizaron análisis de biomarcadores de magnesio y calcio. Se calculó la relación Ca/Mg en dieta, plasma y orina y se evaluaron los parámetros glicémicos. Las mujeres con obesidad tenían niveles bajos de magnesio en la dieta, concentraciones reducidas de magnesio en plasma y eritrocitos, y excreción urinaria de magnesio elevada. La concentración plasmática de calcio fue menor en pacientes con obesidad, y la excreción urinaria de calcio fue mayor que en el grupo de mujeres con peso normal. La ingesta dietética de magnesio y calcio por kilogramo de peso corporal por día fue menor en las mujeres con obesidad, que en el grupo control. La relación Ca/Mg en plasma y orina estaba elevada en mujeres con obesidad. Se encontró una correlación significativa entre los biomarcadores de magnesio y los parámetros de calcio. La relación Ca / Mg parece estar asociada con la resistencia a la insulina en mujeres con obesidad.

Magnesium parameters and their association with lipid metabolism markers in obese women

ABSTRACT Background: The objective of this study was to evaluate whether low magnesium concentration is related to increased cardiovascular risk in obese women. Methods: This case-control study included women, who were divided into two groups: case (BMI>35 kg/m2) and control group (18.5>BMI>24.9 kg/m2). Body weight, height, waist, neck and hip circumference were measured according to the methodology described by the Ministry of Health. The analyses of plasma, erythrocyte, and urinary magnesium concentrations were performed using the inductively coupled plasma optical emission spectrometry method. The lipid fractions were analyzed according to the enzymatic colorimetric method using a Cobas Integra automatic biochemical analyzer. Results: Mean plasma and erythrocyte magnesium concentrations were lower in the obese women compared to the control group (p<0.05). The urinary excretion of this mineral showed a significant difference between the two groups (p<0.05), and the obese women excreted a higher amount of magnesium in the urine. With regard to the cardiovascular risk parameters, obese women demonstrated higher values compared to the control group (p<0.05). The study showed a negative correlation between erythrocyte magnesium and systolic and diastolic blood pressure in the control group (p<0.05). Conclusion: These results indicate that obese women exhibit changes in nutritional status with regard to magnesium, with reduced concentrations in plasma and erythrocytes, and increased concentration in the urine. However, the results do not suggest a role of magnesium in protection against cardiovascular risk factors in the patients evaluated in this study.

RESUMEN El objetivo de este estudio fue evaluar si una concentración baja de magnesio está relacionada con un mayor riesgo cardiovascular en mujeres obesas. Métodos: Este estudio de casos y controles incluyó mujeres, que se dividieron en dos grupos: grupo de casos (IMC>35 kg/m2) y control (18,5>IMC>24,9 kg/m2). El peso corporal, la altura, la cintura, la circunferencia del cuello y la cadera se midieron según la metodología descrita por el Ministerio de Salud. Los análisis de las concentraciones de magnesio en plasma, eritrocitos y orina se realizaron utilizando el método de espectrometría de emisión óptica de plasma acoplado inductivamente. Las fracciones lipídicas se analizaron según el método colorimétrico enzimático utilizando un analizador bioquímico automático Cobas Integra. Resultados: Las concentraciones medias de magnesio en plasma y eritrocitos fueron menores en las mujeres obesas en comparación con el grupo de control (p<0.05). La excreción urinaria de este mineral mostró una diferencia significativa entre los dos grupos (p<0.05), y las mujeres obesas excretaron una mayor cantidad de magnesio en la orina. En cuanto a los parámetros de riesgo cardiovascular, las mujeres obesas mostraron valores más altos en comparación con el grupo control (p<0,05). El estudio mostró una correlación negativa entre el magnesio de los eritrocitos y la presión arterial sistólica y diastólica en el grupo de control (p<0,05). Conclusión: Estos resultados indican que las mujeres obesas presentan cambios en el estado nutricional con respecto al magnesio, con concentraciones reducidas en el plasma y eritrocitos, y concentración aumentada en la orina. Sin embargo, los resultados no sugieren un papel del magnesio en la protección contra los factores de riesgo cardiovascular en los pacientes evaluados en este estudio.

Associations between taste sensitivity, preference for sweet and salty flavours, and nutritional status of adolescents from public schools / Associação entre sensibilidade gustativa, preferência aos sabores doce e salgado e estado nutricional de adolescentes

ABSTRACT Objective This study aimed to investigate the associations between taste sensitivity, preference for sweet and salty flavours, and nutritional status of adolescents in public schools. Methods We used a cross-sectional study involving 1,036 adolescents of both sexes, aged 10-19 years. Preference for sweet or salty flavours and preference for foods high in sugar or sodium were evaluated. Measurements of body mass index and taste flavour intensity recognition were conducted. Results Most participants were unable to identify the flavours and/or intensities, and only 18.0% of participants were able to correctly identify both the flavour and intensity of the samples. Most participants (82.1%) preferring sweet foods had low sensitivity to this taste, just as a large proportion of individuals preferring saltiness (82.3%) were less sensitive to salt (p<0.001). Preference for saltiness was associated with pre-obesity. Conclusion We found an association between a preference for sweet or salty flavours and nutritional status, highlighting the importance of poor food choices in the development of obesity and other chronic diseases.

RESUMO Objetivo Este estudo teve como objetivo investigar a associação entre a sensibilidade gustativa, a preferência pelos sabores doce e salgado e o estado nutricional de adolescentes em escolas públicas. Métodos Estudo de natureza transversal, envolvendo 1.036 adolescentes de ambos os sexos, com idade entre 10 e 19 anos. A preferência pelos sabores doce e salgado e por alimentos ricos em açúcar ou sódio foi avaliada. Medidas do índice de massa corporal e testes de reconhecimento de gosto-intensidade foram conduzidos. Resultados A maioria dos participantes foi incapaz de identificar os sabores e/ou intensidades e somente 18,0% dos participantes foram capazes de identificar corretamente o sabor e intensidade das amostras. A maioria dos participantes (82,1%) preferiram alimentos doces e tiveram baixa sensibilidade a esse gosto, bem como uma grande proporção de indivíduos que preferem salgado (82,3%) eram menos sensíveis ao sal (p<0,001). A preferência pelo gosto salgado foi associada com excesso de peso. Conclusão Foi encontrada uma associação entre a preferência pelos sabores doce e salgado e o estado nutricional, destacando a importância de escolhas alimentares pobres no desenvolvimento de obesidade e outras doenças crônicas.

Hypomagnesemia and its relation with chronic low-grade inflammation in obesity / Hipomagnesemia e sua relação com a inflamação crônica de baixo grau na obesidade

Summary Introduction: The accumulation of visceral fat in obesity is associated with excessive production of proinflammatory adipokines, which contributes to low-grade chronic inflammation state. Moreover, the literature has shown that mineral deficiency, in particular of magnesium, has important role in the pathogenesis of this metabolic disorder with relevant clinical repercussions. Objective: To bring updated information about the participation of hypomagnesemia in the manifestation of low-grade chronic inflammation in obese individuals. Method: Articles published in PubMed, SciELO, LILACS and ScienceDirect, using the following keywords: "obesity," "magnesium" and "low grade inflammation." Results: Scientific evidence suggests that magnesium deficiency favors the manifestation of low-grade chronic inflammation in obese subjects. Conclusion: From literature data, it is evident the participation of magnesium through biochemical and metabolic reactions in protecting against this metabolic disorder present in obesity.

Resumo Introdução: O acúmulo de gordura visceral na obesidade está associado à produção excessiva de adipocinas pró-inflamatórias, o que contribui para o estado de inflamação crônica de baixo grau. A literatura também tem mostrado que a deficiência de minerais, em particular do magnésio, possui papel importante na patogênese desse distúrbio metabólico com repercussões clínicas relevantes. Objetivo: Trazer informações atualizadas sobre a participação da hipomagnesemia na inflamação crônica de baixo grau em indivíduos obesos. Método: Bases de dados Pubmed, SciELO, Lilacs e ScienceDirect, utilizando as palavras-chave: "obesity", "magnesium" e "low grade inflammation". Resultados: As evidências científicas sugerem que a deficiência de magnésio favorece a manifestação da inflamação crônica de baixo grau em indivíduos obesos. Conclusão: É evidente a participação do magnésio, por meio de reações bioquímicas e metabólicas, na proteção contra esse distúrbio metabólico presente na obesidade.

Zinc and metalloproteinases 2 and 9: What is their relation with breast cancer? / Zinco e metaloproteinases 2 e 9: qual é a relação com câncer de mama?

Summary Zinc is the catalytic component of proteins that regulate responses to DNA damage, intracellular signaling enzymes, and matrix metalloproteinases, which are important proteins in carcinogenesis. The objective of this review is to bring current information on the participation of zinc and matrix metalloproteinases types 2 and 9 in mechanisms involved in the pathogenesis of breast cancer. We conducted a literature review, in consultation with the PubMed, Lilacs, and Scielo databases. The zinc and cysteine residues are structural elements shared by all members of the family of matrix metalloproteinases, and these proteins appear to be involved in the propagation of various types of neoplasms, including breast cancer. Moreover, transported zinc is likely to be used for the metalation of the catalytic domain of the newly synthesized metalloproteinases before the latter are secreted. Accordingly, increase in zinc concentrations in cellular compartments and the reduction of this trace element in the blood of patients with breast cancer appear to alter the activity of metalloproteinases 2 and 9, contributing to the occurrence of malignancy. Thus, it is necessary to carry out further studies with a view to clarify the role of zinc and metalloproteinases 2 and 9 in the pathogenesis of breast cancer.

Resumo O zinco é componente catalítico de proteínas que regulam respostas a danos no DNA, enzimas de sinalização intracelular e metaloproteinases de matriz, proteínas importantes na carcinogênese. O objetivo desta revisão é trazer informações atualizadas sobre a participação do zinco e das metaloproteinases de matriz dos tipos 2 e 9 em mecanismos envolvidos na patogênese do câncer de mama. Realizou-se um levantamento bibliográfico, mediante consulta às bases de dados PubMed, Scielo e Lilacs. O zinco e os resíduos de cisteína são elementos estruturais compartilhados por todos os membros da família das metaloproteinases de matriz, as quais parecem estar envolvidas na propagação de vários tipos de neoplasias, incluindo o câncer de mama. Além disso, é provável que o zinco transportado seja utilizado para metalação do domínio catalítico das metaloproteinases recentemente sintetizadas antes de serem segregadas. Nesse sentido, o aumento das concentrações de zinco em compartimentos celulares e a redução desse oligoelemento no sangue de pacientes com câncer de mama parecem alterar a atividade das metaloproteinases 2 e 9, contribuindo para a ocorrência de tumor maligno. Assim, faz-se necessária a realização de novos estudos na perspectiva de esclarecer o papel do zinco e das metaloproteinases 2 e 9 na patogênese do câncer de mama.

Role of vitamin D in insulin resistance in obese individuals

BACKGROUND: Vitamin D is a fat-soluble compound responsible for promoting intestinal absorption of calcium, and this, in turn, acts as a signal transmitter or activator as protein in secretory processes and release of hormones. VitaminD receptors are distributed in various tissues of the body and involved in biochemical reactions in the pathogenesis of several diseases, such as obesity. OBJECTIVE: The aim of this article is to provide updated information on the role of vitamin D in insulin resistance inobese individuals. METHODS: It was conducted a search of articles published in PubMED, SciELO, and LILACS database, without limit forthe year of publication, using the keywords"vitamin D","insulin resistance",and "obesity". RESULTS: Excess adipose tissue seems to impair insulin signaling by inhibiting the phosphorylation of its receptor, resultingin insulin resistance. Studies have evidenced role of vitamin D in mechanisms involved in the pathogenesis of insulin resistance in obesity by acting in improving glycemic control both by increasing hepatic and peripheral glucoseup take and by promoting the secretion of this hormone. CONCLUSIONS: Vitamin D exerts a protective effect in the treatment and prevention of insulin resistance in patients with obesity and protects the body against oxidative stress and chronic inflammation, contributing to glycemic control. Unfortunately, current data related to the effects of vitamin D supplementation on insulin resistance are still inconclusive

Dietary intake of vitamin D and its relation to insulin resistance in obese women / Ingestão dietétíca de vitamina D e sua relação com a resistência à insulina em mulheres obesas

The aim of this study was to assess the relation between dietary intake of vitamin D and insulin resistance in obese and nonobese women. This cross-sectional study included 93 women, aged between 20 and 50 years, who were subdivided into two groups: the obese group (n = 46) and the agematched control group (n = 47). Vitamin D and calcium intake was monitored using 3-day food records and Dietpro software version 5.1. Measurements of serum glucose and serum insulin were based on an enzymatic colorimetric method and a chemiluminescence assay, respectively. Insulin resistance was assessed by means of homeostasis model assessment of insulin resistance (HOMA-IR). The median values of vitamin D content in the diet were found to be lower than those recommended, although there was a significant difference between groups (p < 0.001). The mean values of calcium intake were found to be above the recommendations, although there was no significant difference between the groups (p > 0.05). The values of serum glucose, serum insulin, and HOMA-IR were higher in obese women than in the control group. The correlation analysis indicated that the association between the dietary intake of vitamin D and insulin resistance was not significant. The results of this study indicate that dietary vitamin D does not influence parameters of glycemic control in obese women (AU)

O objetivo do estudo foi avaliar a relação entre a ingestão dietética de vitamina D e resistência à insulina em mulheres obesas e não obesas. Este estudo transversal incluiu 93 mulheres, com idades entre 20 e 50 anos, que foram subdivididos em dois grupos: obesos (n = 46) e o grupo controle pareados por idade (n = 47). A ingestão de vitamina D e cálcio foi estimada por meio dos registros alimentares de 3 dias e analisada pelo software DietPro versão 5.1. As mensurações séricas de glicose e insulina foram baseadas em um método colorimétrico enzimático e um ensaio de quimiluminescência, respectivamente. A resistência à insulina foi avaliada por meio do modelo de avaliação da homeostase da resistência à insulina (HOMA-IR). Os valores médios do teor de vitamina D na dieta foram mais baixos do que os recomendados, embora houvesse uma diferença significativa entre os grupos (p <0,001). Os valores médios de ingestão de cálcio estavam acima das recomendações, apesar de não haver diferença significativa entre os grupos (p> 0,05). Os valores de glicose sérica, insulina sérica, e HOMA-IR foram maiores em mulheres obesas que no grupo de controle. A análise de correlação indicou que a associação entre a ingestão de vitamina D e resistência à insulina não foi significativa. Os resultados deste estudo indicam que a vitamina D na dieta não influencia os parâmetros de controle glicêmico em mulheres obesas (AU)

Teor de Vitamina D na dieta e sua relação com marcador de inflamação em pacientes renais crônicos hemodialisados / Vitamin D content in the diet and its relation to inflammation marker in renal chronic Hemodialysis patients

Introdução: Estudos têm mostrado deficiência de vitamina D em dietas consumidas por doentes renais crônicos em hemodiálise, o que parece contribuir para a inflamação nesses pacientes. Objetivo: O estudo avaliou a relação entre o teor de vitamina D na dieta e as concentrações séricas da proteína C reativa em doentes renais crônicos em hemodiálise. Métodos: Estudo de natureza transversal com caso e controle, envolvendo 93 indivíduos, com idade entre 20 e 60 anos, sendo distribuídos em dois grupos: grupo controle (saudáveis, n=54) e grupo caso (doentes renais, n=39). A ingestão de vitamina D foi avaliada por meio de registro alimentar de três dias, utilizando o programa Dietpro versão 5.i. A proteína C reativa sérica foi analisada pelo método de quimioluminescência. Os dados foram analisados no programa estatístico SPSS for Windows 20.0. Resultados: Os valores médios da ingestão de vitamina D estavam inferiores às recomendações, sem diferença estatística entre os grupos (p>0,05). As concentrações séricas médias da proteína C reativa foram 2,02 ± 1,14 mg/L para os doentes renais crônicos e 1,70 ± 1,41 mg/L para o grupo controle, com diferença significativa entre os grupos (p0,05). Conclusão: Portanto, os pacientes renais crônicos ingerem alimentos com teor baixo de vitamina D. Porém, o estudo não revela correlação entre o teor dietético dessa vitamina e as concentrações séricas da proteína C reativa, sugerindo que a ingestão de vitamina D parece não influenciar no processo inflamatório presente nesses pacientes (AU)

Introduction: Studies have shown vitamin D deficiency in diets consumed by hemodialysis patients, which seems to contribute to inflammation in these patients. Objective: To study the relationship between vitamin D content in the diet and serum concentrations of C-reactive protein in hemodialysis patients. Methods: Transversal study with cases and controls, involving 93 individuals, aged between 20 and 60 years, divided into two groups: control group (healthy, n = 54) and case group (kidney patients, n = 39). Intake of vitamin D was assessed by three days food diaries using the software DietPro version 5.i. Serum C-reactive protein was analyzed by chemi luminescence. The data were analyzed with the software SPSS for Windows 20.0. Results: The mean values of vitamin D intake were lower than those recommendations, with no statistical difference between the groups (p> 0.05). The average serum concentrations of C-reactive protein were 2.02 ± 1.14 mg/L for hemodialysis patients and 1.70 ± 1.41 mg/L for the control group, with significant difference between groups (p 0.05). Conclusion: Therefore, chronic renal patients eating foods low in vitamin D. However, the study reveals correlation between dietary content of this vitamin and serum concentrations of C-reactive protein, suggesting that vitamin D intake does not influence the inflammatory process present in these patients (AU)

Relação entre parâmetros de adiposidade e proteína C reativa em mulheres com câncer de mama / Relationship between adiposity parameters and C-reactive protein in women with breast cancer

Introdução: O câncer de mama é uma doença multifatorial que envolve desequilíbrio entre fatores genéticos, dietéticos e hormonais. Pesquisas mostram que o excesso de peso corporal, associado a diversas desordens metabólicas como a inflamação crônica de baixo grau, parece estar envolvido no desenvolvimento e progressão da doença. Assim, objetivo use avaliar a relação entre os parâmetros de adiposidade e as concentrações séricas de proteína C reativa em mulheres com câncer de mama. Métodos: Estudo transversal com casos e controles, envolvendo 68 mulheres, na faixa etária entre 20 e 59 anos, distribuídas em dois grupos: caso (câncer de mama, n=34) e controle (sem câncer de mama, n=34). Foram realizadas medidas do índice de massa corpórea e da circunferência da cintura. A determinação da proteína C reativa sérica foi pelo método enzimático colorimétrico. Resultados: Os valores médios do índice de massa corpórea das mulheres com câncer de mama foram de 26,17 ± 4,91 kg/m² e 22,78 ± 1,36 Kg/m² para o controle (p <0,05). Houve correlação positiva entre o índice de massa corpórea, a circunferência da cintura e as concentrações séricas de proteína C reativa (p=0,036 e p=0,009, respectivamente). Conclusão: A partir da análise dos dados, verifica-se uma possível influência dos parâmetros de adiposidade sobre as concentrações séricas de proteína C reativa nas mulheres com câncer de mama, evidenciando a participação do acúmulo de gordura corporal no desenvolvimento dessa doença (AU)

Introduction: Breast cancer is a multifactorial disease involving imbalance between genetic, dietary and hormonal factors. Research has shown that overweight associated with various metabolic disorders, such as chronic low-grade inflammation, which seems to be involved in development and progression of breast cancer. The objective was to evaluate the relationship between adiposity parameters and serum concentrations of C-reactive protein in women with breast cancer. Methods: Cross-sectional study with cases and controls, involving 68 women, aged between 20 and 59 years, divided into two groups: case (breast cancer, n = 34) and control (without breast cancer, n = 34). Body mass index and waist circumference measurements were performed. The determination of serum C-reactive protein was by enzymatic colorimetric method. Results: The mean body mass index of women with breast cancer were 26.17 ± 4.91 kg/m² and 22.78 ± 1.36 kg/m² for the control (p< 0.05). The average concentration of C-reactive protein of women with breast cancer were 2.33 ± 3.57 mg/L and 1.90 ± 0.89 mg/L for the control (p< 0.05). There was a positive correlation between body mass index, waist circumference and serum concentrations of C-reactive protein (p=0.036 and p=0.009, respectively). Conclusion: From data analysis, there is a possible influence of adiposity parameters on serum concentrations of C-reactive protein in women with breast cancer, highlighting the participation of body fat accumulation in the development of this disease (AU)

Influência da hipomagnesemia sobre a homeostase do ferro e estresse oxidativo no diabetes mellitus tipo 2 / Influence of hypomagnesemia on iron homeostasis and oxidative stress in type 2 diabetes mellitus

OBJECTIVE: This review aims to bring updated information about the influence of magnesium deficiency on iron homeostasis and oxidative stress in type 2 diabetics. Data source: A bibliographic search was conducted in the databases Bireme, SciELO, Science Direct, PubMed and Portal.periodicos.Capes using the following descriptors: "diabetes mellitus", "magnesium", "iron", "oxidative stress" and "malondialdehyde". Fifty articles related to this literature were selected. Data synthesis: Several studies have shown the influence of hypomagnesemia on oxidative stress in type 2 diabetics. Deficiency of this mineral seems to be related to the induction of hemolysis, which favors the release of iron with overload of this mineral in the body, allowing an increase of the hydroxyl radical through the Fenton reaction and, consequently, oxidative stress. The increase in free iron contributes significantly to the manifestation of lipid peroxidation, which triggers a sequence of lesions in the cell with loss of selectivity in ion exchange and release of the contents of organelles, such as the hydrolytic enzymes of lysosomes, and the formation of cytotoxic products, such as malondialdehyde. CONCLUSIONS: There is scientific evidence that magnesium deficiency alters iron compartmentalization in the body; however, new studies are needed to bring information that would enable the biochemical understanding of the importance of the balance of magnesium and iron concentrations in protecting against the oxidative stress present in type 2 diabetes

OBJETIVO: Esta revisão visa trazer informações atualizadas sobre a influência da deficiência de magnésio na homeostase do ferro e estresse oxidativo em diabéticos tipo 2. Fonte de dados: O levantamento bibliográfico foi realizado nas bases de dados Bireme, Scielo, Science Direct, periódicos Capes e Pubmed com os seguintes descritores: "diabetes mellitus", "magnésio", "ferro", "estresse oxidativo" e "malondialdeído". Foram selecionados 50 artigos entre os relacionados por essa pesquisa bibliográfica. Síntese dos dados: Diversos estudos têm mostrado a influência da hipomagnesemia sobre o estresse oxidativo em diabéticos tipo 2, sendo que a deficiência desse mineral parece estar relacionada à indução da hemólise dos eritrócitos, que favorece a liberação do ferro com sobrecarga desse mineral no organismo, o que possibilita aumento do radical hidroxila por meio da reação de Fenton e, consequentemente, o estresse oxidativo. O aumento de ferro livre contribui de forma relevante para a manifestação da peroxidação lipídica, que desencadeia sequência de lesões na célula, com perda da seletividade na troca iônica e liberação do conteúdo de organelas, como as enzimas hidrolíticas dos lisossomas e a formação de produtos citotóxicos, como o malondialdeído. CONCLUSÕES: Há evidências científicas de que a deficiência de magnésio altera a compartimentalização do ferro no organismo, entretanto a realização de novos estudos é necessária para trazer informações que permitam o entendimento bioquímico da importância do equilíbrio das concentrações de magnésio e ferro na proteção contra o estresse oxidativo presente no diabetes tipo 2

Effectiveness of an educational intervention to reduce the consumption of high-calorie foods in public school children in Teresina, Piauí (Brazil) / Efectividad de una intervención educativa sobre el consumo de alimentos altos en calorías por niños de escuelas públicas de Teresina, Piauí (Brasil)

Introduction: there is high prevalence of overweight and poor food habits among adolescents, and these factors contribute to the development of chronic diseases. Objective: the aim of this study was to evaluate the effectiveness of an educational intervention designed to reduce the consumption of high-calorie foods in public school children in Teresina, Piaui, Brazil. Materials and methods: quasi-experimental, randomized, quantitative intervention study involving adolescents (n = 126) of both sexes aged 10–14 years. An educational intervention, which involved 9 weekly meetings, was developed. A questionnaire was completed prior and subsequent to the intervention. Associations between variables were examined using a chi-square test (x2). Results and discussion: there was a significant reduction in the consumption of soft drinks and processed juices subsequent to the educational intervention (p = 0.007). It has further reduction in weekly consumption of food like meat and sausage (p = 0.072). Adolescents’ weekly consumption of fried foods and potato chips also decreased significantly subsequent to the educational intervention (p < 0.001). Conclusions: the food and nutrition educational program was efficacious in reducing the adolescents’ intake of high-calorie food and drinks and contributed to an improvement in the quality of food consumed by the schoolchildren evaluated (AU)

Introducción: existe una alta prevalencia de sobrepeso y hábitos alimentarios pobres entre los adolescentes, y estos factores contribuyen al desarrollo de enfermedades crónicas. Objetivo: el objetivo de este estudio fue evaluar la efectividad de una intervención educativa diseñada para reducir el consumo de alimentos con alto contenido calórico en los niños de las escuelas públicas en Teresina, Piauí (Brasil). Material y métodos: estudio cuasi-experimental, aleatorizados y de intervención cuantitativo realizado con adolescentes (n = 126), con edades comprendidas entre 10 y 14 años, de ambos sexos. La intervención educativa se desarrolló durante nueve semanas, con reuniones semanales. Se realizó una encuesta previa y posterior a la intervención. Las asociaciones entre las variables fueron examinadas usando una prueba de chi-cuadrado (x2). Resultados: se observó una reducción significativa en el consumo de refrescos y jugos procesados posterior a la intervención educativa (p = 0,007). Tiene una mayor reducción en el consumo semanal de alimentos embutidos (p = 0,072). El consumo semanal de los adolescentes de alimentos fritos y patatas fritas también se redujo significativamente después de la intervención educativa (p < 0,001). Conclusiones: el programa educativo de alimentación y nutrición fue eficaz en la reducción de la ingesta de alimentos altos en calorías y bebidas de los adolescentes, lo cual contribuyó a una mejora en la calidad de los alimentos consumidos por los niños de las escuelas evaluadas (AU)

Participação do selênio no diabetes mellitus tipo 2 / Participation of selenium in type 2 diabetes mellitus

OBJECTIVE: This review aims to bring updated information on the relationship between oxidative stress and the role of selenium as antioxidant nutrient in mechanisms involved in the pathogenesis of type 2 diabetes mellitus. Data source: The bibliographic survey was conducted in PubMed, SciELO and Lilacs, considering the 2002-2014 period, and included the following types of studies: randomized or quasi-randomized controlled trials, cohort, case-control study, case series and case report. Forty-nine pertinent scientific studies were selected. Data synthesis: Several studies have demonstrated the contribution of acute and/or chronic hyperglycemia to the manifestation of oxidative stress in type 2 diabetic patients. Accordingly, selenium has an important participation in controlling this disease due to its antioxidant role in the elimination of free radicals, present in excess, and because it blocks the activation of nuclear transcription factor kappa B, a regulator sensitive to oxidants that stimulates the production of inflammatory mediators (cytokines) and adhesion molecules. CONCLUSIONS: There is convincing experimental evidence demonstrating the involvement of selenium in glycemic control. However, current information is still scarce and inconsistent, and it is necessary to conduct further studies on the subject to determine the selenium intake safety range as well as clarify the influence of this mineral on the manifestation of type 2 diabetes mellitus and its associated disorders

OBJETIVO: Esta revisão visa trazer informações atualizadas sobre a relação entre o estresse oxidativo e o papel do selênio como nutriente antioxidante em mecanismos envolvidos na patogênese do diabetes mellitus tipo 2. Fonte de dados: O levantamento bibliográfico foi realizado nas bases de dados Pubmed, SciELO e Lilacs considerando o período de 2002 a 2014 e abrangeu os seguintes tipos de estudos: ensaios clínicos controlados randomizados ou quase-randomizados, coorte, estudo caso-controle, série de casos e relato de caso. Foram selecionados 49 que se relacionavam com esta pesquisa bibliográfica. Síntese dos dados: Várias pesquisas têm demonstrado a contribuição do estado hiperglicêmico agudo e/ou crônico na manifestação do estresse oxidativo em pacientes diabéticos tipo 2. Nesse sentido, o selênio possui participação importante no controle dessa doença, devido ao seu papel antioxidante na eliminação dos radicais livres, presentes em excesso, e por bloquear a ativação do fator de transcrição nuclear kappa B, um regulador sensível a oxidantes que estimula a produção de mediadores inflamatórios (citocinas) e de moléculas de adesão. CONCLUSÕES: Existem evidências experimentais convincentes que demonstram a participação do selênio no controle glicêmico. No entanto, as informações atuais ainda são bastante escassas e inconsistentes e faz-se necessária a realização de novos estudos sobre o tema a fim de determinar a faixa de segurança de ingestão de selênio, além de obter esclarecimentos acerca da influência do mineral sobre a manifestação do diabetes mellitus tipo 2 e das desordens a ele associadas

Considerações sobre a Influência do Cortisol no Metabolismo do Zinco na Obesidade / Considerations on Cortisol Influence on Zinc Metabolism in Obesity

O acúmulo de gordura visceral na obesidade parece estar associado com a presença de desordens endócrinas, destacando-se a disfunção do eixo Hipotalâ - mico-Pituitário-Adrenal, que se encontra hiperresponsivo, acentuando a liberação de cortisol em pacientes obesos. A literatura mostra que o cortisol pode influenciar, de forma indireta, as concentrações intracelulares e plasmáticas de zinco, o que favorece a compartimentalização do mineral nos eritrócitos. Portanto, o objetivo desta revisão é trazer dados sobre a influência do cortisol na homeostase do zinco em indiví- duos obesos. Foi conduzida uma revisão narrativa, sendo que o levantamento bibliográfico foi realizado nas bases de dados Pubmed, SciELO, LILACS, utilizando-se as palavras-chave: 'obesity', 'zinc', 'cortisol', 'metallothionein'. Diante da gravidade dos distúrbios metabólicos presente na obesidade, torna-se evidente a necessidade de esclarecimentos sobre a influência da hipersecreção do cortisol sobre o metabolismo do zinco em pacientes obesos, o que possibilitará o desenvolvimento de estratégias, como, por exemplo, a possível suplementação com zinco na perspectiva da prevenção e tratamento de distúrbios associados a esta doença crônica (AU)

Visceral fat accumulation in obesity appears to be associated with the presence of endocrine disorders, highlighting dysfunction of the hypothalamic-pituitaryadrenal axis, which is hyper-responsive, enhancing the release of cortisol in obese patients. The literature shows that cortisol can influence, indirectly, the intracellular and plasma zinc concentrations, which promotes the compartmentalization of this mineral in erythrocytes. Therefore, the aim of this review is to bring data on the influence of cortisol in the metabolic behavior of zinc in obese individuals. A narrative review was conducted, and the literature was carried out in the databases PubMed, SciELO, Lilacs, using the following key words: 'obesity', 'zinc', 'cortisol', 'metallothionein'. Given the severity of metabolic disorders found in obesity, it becomes evident the need to clarify the influence of cortisol hypersecretion on zinc metabolism in obese patients, which will enable the development of strategies, for example, the possible supplementation with zinc in the perspective of prevention and treatment of disorders associated with this chronic disease (AU)