Detalhe da pesquisa
1.
Doravirine responses to HIV-1 viruses bearing mutations to NRTIs and NNRTIs under in vitro selective drug pressure.
J Antimicrob Chemother
; 78(8): 1921-1928, 2023 08 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37303226
2.
Cell culture selections reveal favourable drug resistance profiles for doravirine and islatravir.
J Antimicrob Chemother
; 76(8): 2137-2142, 2021 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33855437
3.
Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir.
Retrovirology
; 15(1): 56, 2018 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-30119633
4.
Antiviral Activity of Bictegravir and Cabotegravir against Integrase Inhibitor-Resistant SIVmac239 and HIV-1.
Antimicrob Agents Chemother
; 61(12)2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28923862
5.
M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.
J Antimicrob Chemother
; 72(11): 3008-3011, 2017 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28961903
6.
HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters.
J Antimicrob Chemother
; 72(8): 2171-2183, 2017 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28472323
7.
Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors.
J Antimicrob Chemother
; 72(3): 727-734, 2017 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28069884
8.
Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay.
J Med Virol
; 89(3): 397-407, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27509184
9.
Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase.
Antimicrob Agents Chemother
; 60(1): 600-8, 2016 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26574011
10.
Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors.
J Antimicrob Chemother
; 71(7): 1948-53, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27029845
11.
Dolutegravir resistance mutation R263K cannot coexist in combination with many classical integrase inhibitor resistance substitutions.
J Virol
; 89(8): 4681-4, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25653436
12.
The Combination of the R263K and T66I Resistance Substitutions in HIV-1 Integrase Is Incompatible with High-Level Viral Replication and the Development of High-Level Drug Resistance.
J Virol
; 89(22): 11269-74, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26311878
13.
Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.
J Virol
; 89(23): 12002-13, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26378179
14.
The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline.
J Antimicrob Chemother
; 70(3): 750-6, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25433008
15.
Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout.
J Antimicrob Chemother
; 70(10): 2810-5, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26142476
16.
The connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K resistance mutation by diminishing viral replication capacity.
J Virol
; 88(3): 1536-47, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24227862
17.
Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors.
J Virol
; 88(17): 9683-92, 2014 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24920794
18.
Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 58(8): 4515-26, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24867966
19.
HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase.
Antimicrob Agents Chemother
; 58(12): 7141-50, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25224008
20.
Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 57(11): 5649-57, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-24002090