Detalhe da pesquisa
1.
Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania.
J Enzyme Inhib Med Chem
; 35(1): 1345-1358, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-32588679
2.
5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms.
Bioorg Med Chem
; 24(16): 3790-800, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27349574
3.
Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction-Optimization Strategy Applied to Paullones.
ChemMedChem
; 18(10): e202300036, 2023 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36847711
4.
The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones.
PLoS One
; 18(11): e0292946, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-38032881
5.
Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi.
Free Radic Biol Med
; 130: 23-34, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30359758