Detalhe da pesquisa
1.
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR.
ACS Med Chem Lett
; 15(5): 583-589, 2024 May 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38746885
2.
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J Med Chem
; 67(11): 8988-9027, 2024 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38770784
3.
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
J Med Chem
; 64(18): 13704-13718, 2021 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34491761
4.
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
J Med Chem
; 64(19): 14498-14512, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34570508
5.
Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1.
SLAS Discov
; 24(2): 121-132, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30543471
6.
Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions.
Mol Cancer Ther
; 17(5): 885-896, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29483211
7.
Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation.
ACS Med Chem Lett
; 7(5): 514-9, 2016 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27190603
8.
Cellular assay optimization: part II: the use of a simple integrated robotic work cell to allow the multiplexed batching of cellular assays.
J Biomol Screen
; 16(9): 967-73, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21844326
9.
Cellular assay optimization: part I: the use of large-scale transiently transfected cryobanks and introduction of a c-Myc tag to design a standardized ELISA process.
J Biomol Screen
; 16(9): 959-66, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21841143