Detalhe da pesquisa
1.
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Bioorg Med Chem
; 78: 117130, 2023 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36542958
2.
Cu(II)-Catalyzed Unsymmetrical Dioxidation of gem-Difluoroalkenes to Generate α,α-Difluorinated-α-phenoxyketones.
J Org Chem
; 87(16): 10710-10725, 2022 08 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35914193
3.
Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists.
Bioorg Med Chem Lett
; 78: 129021, 2022 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36228968
4.
Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists.
Bioorg Med Chem Lett
; 76: 128988, 2022 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36113671
5.
Acid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers.
J Org Chem
; 86(3): 2297-2311, 2021 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33471529
6.
Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes.
J Org Chem
; 85(16): 10451-10465, 2020 08 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32697905
7.
Organocatalytic Strategy for Hydrophenolation of Gem-Difluoroalkenes.
Tetrahedron
; 75(32): 4325-4336, 2019 Aug 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32103843
8.
Correction to "Acid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers".
J Org Chem
; 86(5): 4374, 2021 Mar 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33621093
9.
Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones.
Angew Chem Int Ed Engl
; 54(8): 2361-5, 2015 Feb 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25581845
10.
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069.
J Med Chem
; 65(21): 14843-14863, 2022 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36270630
11.
Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
J Med Chem
; 65(8): 6273-6286, 2022 04 28.
Artigo
Inglês
| MEDLINE | ID: mdl-35417155
12.
Correction to "Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069".
J Med Chem
; 66(1): 1082, 2023 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36542814
13.
Exploiting the unusual effects of fluorine in methodology.
Chem Commun (Camb)
; 53(53): 7168-7181, 2017 Jun 29.
Artigo
Inglês
| MEDLINE | ID: mdl-28503693
14.
Base Catalysis Enables Access to α,α-Difluoroalkylthioethers.
Org Lett
; 19(7): 1570-1573, 2017 04 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28332397
15.
Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition.
Chem Sci
; 6(2): 1212-1218, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29560207