Detalhe da pesquisa
1.
Therapy-induced APOBEC3A drives evolution of persistent cancer cells.
Nature
; 620(7973): 393-401, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37407818
2.
Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.
Nat Chem Biol
; 19(10): 1215-1222, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37127754
3.
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.
Mol Cell
; 67(1): 5-18.e19, 2017 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28673542
4.
Exploration of bromodomain ligand-linker conjugation sites for efficient CBP/p300 heterobifunctional degrader activity.
Bioorg Med Chem Lett
; 102: 129676, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38408512
5.
Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.
Blood
; 131(18): 2065-2073, 2018 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29519804
6.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Nat Chem Biol
; 14(4): 405-412, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29507391
7.
Nucleosome mapping across the CFTR locus identifies novel regulatory factors.
Nucleic Acids Res
; 41(5): 2857-68, 2013 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23325854
8.
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
Blood
; 120(14): 2843-52, 2012 Oct 04.
Artigo
Inglês
| MEDLINE | ID: mdl-22904298
9.
Nucleosome occupancy reveals regulatory elements of the CFTR promoter.
Nucleic Acids Res
; 40(2): 625-37, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-21948798
10.
CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas.
Cancers (Basel)
; 16(2)2024 Jan 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38275898
11.
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.
Nat Struct Mol Biol
; 30(8): 1160-1171, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37488358
12.
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
Nat Cancer
; 4(5): 754-773, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37237081
13.
Molecular mechanisms controlling CFTR gene expression in the airway.
J Cell Mol Med
; 16(6): 1321-30, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21895967
14.
A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function.
Thorax
; 67(5): 385-91, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22169360
15.
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.
Proc Natl Acad Sci U S A
; 106(47): 19934-9, 2009 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19897727
16.
An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells.
Nucleic Acids Res
; 37(4): 1086-94, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19129223
17.
Selective targeting of MYC mRNA by stabilized antisense oligonucleotides.
Oncogene
; 40(47): 6527-6539, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34650218
18.
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
Cell Chem Biol
; 28(4): 503-514.e12, 2021 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33400925
19.
Screening and Validation of Molecular Targeted Radiosensitizers.
Int J Radiat Oncol Biol Phys
; 111(5): e63-e74, 2021 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34343607
20.
A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation.
Cancer Cell
; 39(3): 380-393.e8, 2021 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33689703