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1.
Unfallchirurg ; 115(6): 554-65, 2012 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-22159502

RESUMO

During a 1-day workshop organized by the German Society of Orthopaedics and Traumatology (DGOU) 15 German accident researchers used different approaches to improve the effectiveness of accident prevention for pedestrians and bicyclists on German roads. The main results of this analysis show: Fatal injuries of pedestrians have been significantly reduced by 82% between 1970 (n=6.056) and 2007 (n=695). Similarly, fatalities of bicyclists have been reduced during the same time period from 1,835 to 425 which amount to almost 80%. However, the total number of injured cyclists increased almost twice, i.e. from 40,531 (in 1979) to 78,579 (in 2007) a fact that needs to be analyzed in more detail. Although scientifically proven to provide protection against severe head injuries, helmets are worn less frequently by adolescents and women as compared to younger children and men. Fatalities of bicyclists might be reduced by using Dobli mirrors which allow the truck driver to see the bicyclist when turning right. Recently developed sensors are able to detect pedestrians walking closely (<2.5 m) and warn the truck driver acoustically. Bicycle lanes should be planned for one direction only, separated from the pedestrian way and large enough (2.0 m are safer than 1.6 m). Traffic education for school beginners and younger children should be repeated to be effective. Training for elderly bicyclists in cities with heavy traffic would also be reasonable. Active security systems in cars like ESP (electronic stability program), BAS (brake assist system), special light systems for curves, and night vision utilities are most effective to prevent collision with pedestrians and bicyclists. TV spots for bicyclists could help to point out dangerous situations and the proven benefits of wearing a helmet in the same way as previous campaigns, e.g."The 7th Sense" for car drivers.


Assuntos
Acidentes de Trânsito/prevenção & controle , Acidentes de Trânsito/estatística & dados numéricos , Condução de Veículo , Ciclismo/lesões , Ciclismo/estatística & dados numéricos , Veículos Automotores/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adolescente , Adulto , Criança , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Educação de Pacientes como Assunto , Prevalência , Taxa de Sobrevida , Ferimentos e Lesões/prevenção & controle
2.
Unfallchirurg ; 113(5): 366-72, 2010 May.
Artigo em Alemão | MEDLINE | ID: mdl-20376615

RESUMO

The new AIS (Abbreviated Injury Scale) was released with an update by the AAAM (Association for the Advancement of Automotive Medicine) in 2008. It is a universal scoring system in the field of trauma applicable in clinic and research. In engineering it is used as a classification system for vehicle safety. The AIS can therefore be considered as an international, interdisciplinary and universal code of injury severity. This review focuses on a historical overview, potential applications and new coding options in the current version and also outlines the associated problems.


Assuntos
Prevenção de Acidentes/tendências , Acidentes de Trânsito/classificação , Sistemas de Comunicação entre Serviços de Emergência , Telemetria/métodos , Índices de Gravidade do Trauma , Ferimentos e Lesões/diagnóstico , Alemanha , Humanos
3.
Chirurg ; 79(7): 650-6, 2008 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-18351306

RESUMO

BACKGROUND: The role of trauma documentation has grown continuously since the 1970s. Prevention and management of injuries were adapted according to the results of many analyses. Since 1993 there have been two different trauma databases in Germany: the German trauma registry (TR) and the database of the Accident Research Unit (UFO). Modern computer applications improved the data processing. Our study analysed the pros and cons of each system and compared them with those of our European neighbours. METHODS: We compared the TR and the UFO databases with respect to aims and goals, advantages and disadvantages, and current status. Results were reported as means +/- standard errors of the mean. The level of significance was set at P<0.05. RESULTS: There were differences between the two databases concerning number and types of items, aims and goals, and demographics. The TR documents care for severely injured patients and the clinical course of different types of accidents. The UFO describes traffic accidents, accident conditions, and interrelations. The German and British systems are similar, and the French system shows interesting differences. DISCUSSION: The German trauma documentation systems focus on different points. Therefore both can be used for substantiated analyses of different hypotheses. Certain intersections of both databases may help to answer very special questions in the future.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Bases de Dados Factuais/estatística & dados numéricos , Documentação/métodos , Sistema de Registros , Ferimentos e Lesões/epidemiologia , Acidentes de Trânsito/prevenção & controle , Causalidade , Comparação Transcultural , Estudos Transversais , Coleta de Dados/estatística & dados numéricos , Europa (Continente) , Alemanha , Humanos , Reprodutibilidade dos Testes , Ferimentos e Lesões/prevenção & controle
4.
Accid Anal Prev ; 110: 177-186, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29102034

RESUMO

Police crash reports are often the main source for official data in many countries. However, with the exception of fatal crashes, crashes are often underreported in a biased manner. Consequently, the countermeasures adopted according to them may be inefficient. In the case of bicycle crashes, this bias is most acute and it probably varies across countries, with some of them being more prone to reporting accidents to police than others. Assessing if this bias occurs and the size of it can be of great importance for evaluating the risks associated with bicycling. This study utilized data collected in the COST TU1101 action "Towards safer bicycling through optimization of bicycle helmets and usage". The data came from an online survey that included questions related to bicyclists' attitudes, behaviour, cycling habits, accidents, and patterns of use of helmets. The survey was filled by 8655 bicyclists from 30 different countries. After applying various exclusion factors, 7015 questionnaires filled by adult cyclists from 17 countries, each with at least 100 valid responses, remained in our sample. The results showed that across all countries, an average of only 10% of all crashes were reported to the police, with a wide range among countries: from a minimum of 0.0% (Israel) and 2.6% (Croatia) to a maximum of a 35.0% (Germany). Some factors associated with the reporting levels were type of crash, type of vehicle involved, and injury severity. No relation was found between the likelihood of reporting and the cyclist's gender, age, educational level, marital status, being a parent, use of helmet, and type of bicycle. The significant under-reporting - including injury crashes that do not lead to hospitalization - justifies the use of self-report survey data for assessment of bicycling crash patterns as they relate to (1) crash risk issues such as location, infrastructure, cyclists' characteristics, and use of helmet and (2) strategic approaches to bicycle crash prevention and injury reduction.


Assuntos
Acidentes de Trânsito , Ciclismo , Comunicação , Polícia , Acidentes de Trânsito/estatística & dados numéricos , Adulto , Ciclismo/lesões , Croácia , Comparação Transcultural , Feminino , Alemanha , Dispositivos de Proteção da Cabeça , Hospitalização , Humanos , Israel , Masculino , Risco , Segurança , Autorrelato , Fatores Socioeconômicos
5.
Chirurg ; 78(3): 246-53, 2007 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-17180605

RESUMO

AIM: Crash mechanisms, injury patterns, and severity of injury of entrapped motor vehicle occupants were analysed by the Accident Research Unit's scientific teams between 1983 and 2003. RESULTS: Of the 1281 vehicle passenger entrapments in our study, 18.3% happened on highways, 25.6% on federal roads, 35.9% on country roads, and 18.3% on city roads. Of those involved, 69.9% were drivers, 19.4% were front passengers, and 8.5% were rear passengers. Coinvolved objects in car collisions were: other cars 30.9%, trucks 50.2%, objects 18.6%, and motorbikes 0.3%. Coinvolved objects in truck collisions were: other trucks 61.8% and objects 38.2%. The mean Delta-V was 42 km/h (cars 46.2, trucks 32.2). Maximum AIS levels were 31% I, 25.2% II, 19.4% III, 7.8% IV, 7.8% V, and 8.6% VI. Of injuries, 68.7% were to the head, 23.5% to the neck, 50.8% to the chest, 43.6% to upper extremities, 15.4% to the abdomen, 16.4% to the pelvis, and 52.9% to lower extremities. The incidence of multiple injuries (ISS>16) was 23.7%, and mortality was 15.9%. CONCLUSION: Car drivers are more at risk of accidents with entrapment on rural streets, and truck drivers are more at risk on highways. In most cases car occupants crash with trucks or other cars, and truck drivers collide more frequently with other trucks or objects. Besides a high degree of severe single injuries, there is also a high incidence of multiple injury victims and high mortality. Of the fatalities, 74.5% occur during the preclinical course and 24.5% during the clinical course.


Assuntos
Acidentes de Trânsito , Veículos Automotores , Traumatismo Múltiplo/etiologia , Trabalho de Resgate , Ferimentos e Lesões/etiologia , Ferimentos não Penetrantes/etiologia , Escala Resumida de Ferimentos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Estudos Transversais , Feminino , Alemanha , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/epidemiologia , Estudos Prospectivos , Fatores de Risco , Ferimentos e Lesões/epidemiologia
6.
Artigo em Inglês | MEDLINE | ID: mdl-18184485

RESUMO

This study deals with the analysis of lower leg fractures in pedestrians and bicyclists after collisions with passenger cars and examines to what extent the shape and location of the fractures in the lower leg changed, following alterations in the shape of bumpers. It can be assumed that that the bumpers changed in shape and effective impact height, not least due to the realization of the developments of vehicle safety tests as in the context of the European Union Directive 2003/102/EC on pedestrian protection. In addition, consumer protection tests, EuroNCAP, accomplished a change of the injury situation. All of these are mainly focused on pedestrian protection measurements but adopt the bicyclists also in their goal. For the study, traffic accidents from GIDAS (German in-Depth-Accident Study) were selected, which had been documented in the years 1995 to 2004 by scientific teams in Hannover and Dresden (Germany) and for which there is detailed information regarding injury patterns and collision speeds. The accident documentations can be regarded as representative and constitute a random sample with statistic weighing of the data. Altogether 143 cases of lower leg fractures (Tibia/ Fibula) with x-rays of pedestrians and 79 cases of bicyclists were differentiated according to new and old vehicles (year of manufacture before/after 1995). The bumper shapes were divided into classical types (protruding pronouncedly/ protruding integrated /integrated rounded). Besides the injuries to the lower leg, those to thighs and feet were also regarded, and the injury conditions involving the head and trunk were included in the kinematic analytics.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Automóveis/estatística & dados numéricos , Ciclismo/lesões , Fíbula/lesões , Fraturas Ósseas/etiologia , Segurança , Tíbia/lesões , Caminhada/lesões , Alemanha , Humanos , Fatores de Risco
7.
Transl Psychiatry ; 6: e807, 2016 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-27163208

RESUMO

Genetic studies have linked the primate-specific gene locus G72 to the development of schizophrenia and bipolar disorder. Transgenic mice carrying the entire gene locus express G72 mRNA in dentate gyrus (DG) and entorhinal cortex, causing altered electrophysiological properties of their connections. These transgenic mice exhibit behavioral alterations related to psychiatric diseases, including cognitive deficits that can be reversed by treatment with N-acetylcysteine, which was also found to be effective in human patients. Here, we show that G72 transgenic mice have larger excitatory synapses with an increased amount of N-methyl-d-aspartate (NMDA) receptors in the molecular layer of DG, compared with wild-type littermates. Furthermore, transgenic animals have lower number of dentate granule cells with a parallel, but an even stronger decrease in the number of excitatory synapses in the molecular layer. Importantly, we also show that treatment with N-acetylcysteine can effectively normalize all these changes in transgenic animals, resulting in a state similar to wild-type mice. Our results show that G72 transcripts induce robust alterations in the glutamatergic system at the synaptic level that can be rescued with N-acetylcysteine treatment.


Assuntos
Proteínas de Transporte/genética , Giro Denteado/metabolismo , Córtex Entorrinal/metabolismo , Esquizofrenia/genética , Acetilcisteína/farmacologia , Animais , Giro Denteado/efeitos dos fármacos , Giro Denteado/fisiopatologia , Córtex Entorrinal/efeitos dos fármacos , Córtex Entorrinal/fisiopatologia , Sequestradores de Radicais Livres/farmacologia , Humanos , Peptídeos e Proteínas de Sinalização Intracelular , Camundongos , Camundongos Transgênicos , RNA Mensageiro/metabolismo , Receptores de N-Metil-D-Aspartato/metabolismo , Esquizofrenia/metabolismo , Sinapses/metabolismo
8.
Z Orthop Unfall ; 153(2): 177-86, 2015 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-25874397

RESUMO

For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher Verkehrssicherheitsrat as, e.g., "Helmets are cool". Also, spots in TV should be broadcasted like "The 7th sense" or "Traffic compass", which were warning car drivers many years ago of moments of danger but now they could be used to warn bicyclists of life-threatening situations in traffic.


Assuntos
Acidentes de Trânsito/classificação , Acidentes de Trânsito/prevenção & controle , Traumatismos em Atletas/prevenção & controle , Traumatismos em Atletas/cirurgia , Ciclismo/lesões , Equipamentos de Proteção , Acidentes de Trânsito/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Traumatismos em Atletas/classificação , Traumatismos em Atletas/mortalidade , Ciclismo/educação , Ciclismo/estatística & dados numéricos , Causas de Morte , Criança , Traumatismos Craniocerebrais/classificação , Traumatismos Craniocerebrais/mortalidade , Traumatismos Craniocerebrais/prevenção & controle , Traumatismos Craniocerebrais/cirurgia , Estudos Transversais , Feminino , Alemanha , Dispositivos de Proteção da Cabeça , Humanos , Masculino , Pessoa de Meia-Idade
9.
Gene ; 272(1-2): 45-50, 2001 Jul 11.
Artigo em Inglês | MEDLINE | ID: mdl-11470509

RESUMO

Peroxisomes are subcellular organelles with important functions in lipid metabolism that are found in virtually all eucaryotic cells. The peroxisomal membrane contains a number of integral and peripheral membrane proteins involved in the import of peroxisomal matrix proteins and the transport of metabolites across the membrane. The most abundant peroxisomal membrane protein (Pmp) in rat peroxisomes is Pmp22, a 22 kDa protein of unknown function that is encoded by the Pxmp2 gene. To investigate the function of the Pxmp2 gene, we have initiated mouse knockout studies. The expression level of the Pxmp2 mRNA in mice was investigated by Northern blot analysis. Pxmp2 RNA was shown to be differentially expressed with highest expression levels in liver, kidney and in heart tissue. Comparison with other peroxisomal marker genes revealed that the expression of Pxmp2, Pmp70 (Pxmp1) and catalase was regulated independently. Using 5' and 3' RACE we have cloned the full-length cDNA of murine Pxmp2 which comprises 863 nucleotides and have isolated a genomic clone containing the entire murine Pxmp2. We have analyzed the complete intron/exon structure of the Pxmp2 gene which contains five exons spanning about 11 kb on the genomic clone. All intron/exon splice junctions conform to the GT/AG rule. Sequence analysis of the Pxmp2 5' flanking region revealed that it was devoid of a TATA box, but characteristic promoter elements were identified within 250 base pairs upstream of the transcriptional start site. Using a mouse/hamster radiation hybrid panel, Pxmp2 was localized on mouse chromosome 5 at 59 cM.


Assuntos
Genes/genética , Proteínas de Membrana/genética , Animais , Northern Blotting , Mapeamento Cromossômico , Clonagem Molecular , Cricetinae , DNA/química , DNA/genética , DNA Complementar/química , DNA Complementar/genética , Expressão Gênica , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos , Dados de Sequência Molecular , Regiões Promotoras Genéticas , Análise de Sequência de DNA , Distribuição Tecidual
10.
J Orthop Res ; 20(2): 222-32, 2002 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11918301

RESUMO

PURPOSE: Force effect (impact, extent of foot compartment deformation) and result (fracture pattern) for midfoot fractures in car occupants is known. An analysis of the processes in the foot was intended to improve car safety. MATERIALS AND METHODS: Eleven fresh, unfrozen, unpreserved intact human cadavers (age: 36.8 (16-61) years, gender: male, race: Caucasian) were studied 24-72 h after death. In 3 cadavers (5 feet) the experimental design was established: entire cadaver fixed on a special tray in supine position, pendulum with bar impactor hitting the foot plantar to Lisfranc's joint. A custom-made pressure sensor was inserted in the ankle (A), talonavicular (TN) and calcaneocuboid (CC) joints (resolution: 1 cm2, sampling rate: 500/s). RESULTS: Sixteen feet were measured: midfoot fractures were induced in 11 feet. The maximum pressure amounted to 1.22-2.55 MPa (2.04+/-0.412) at 0.005 0.195 s (0.067+/-0.059) after impact. The maximum pressure occurred in 8 (50%) cases in the ankle, in 7 (44%) of the TN and 1 (6%) of the CC joints. A comparison of the first 200 pressure samples after impact of all sensor fields resulted in higher forces in Chopart's joint than in the ankle (t-test: p < 0.001). These force differences were higher in cases with midfoot fractures (mixed model analysis of variance: p = 0.003). CONCLUSION: Due to considerable forces in Chopart's joint we recommend a modification of the actual crash test dummy lower extremity model with an additional load cell that detects forces in the longitudinal direction of the foot axis.


Assuntos
Traumatismos do Tornozelo/etiologia , Traumatismos do Pé/etiologia , Fraturas Ósseas/etiologia , Ossos do Tarso/lesões , Adolescente , Adulto , Traumatismos do Tornozelo/fisiopatologia , Articulação do Tornozelo/fisiopatologia , Fenômenos Biomecânicos , Traumatismos do Pé/fisiopatologia , Fraturas Ósseas/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Ossos do Tarso/fisiopatologia
11.
Cancer Nurs ; 13(3): 158-66, 1990 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-2354428

RESUMO

In order to gain insight into the quality of life from a patient perspective, individuals with cancer receiving home nursing care were given diaries to record the occurrence of health problems. On the average, health problems were reported on 35% of the recording days. Concerns related to somatic discomfort accounted for 76% of all health problems reported. Overall, digestive problems were the most commonly reported category of health problems. Those with lung cancer reported the highest average number of health problems per person (means = 9.3) and the greatest diversity of problems during the recording period. The results also suggest a common core of health problems important to cancer patients, with the relative importance of these problems varying by cancer diagnosis.


Assuntos
Serviços de Assistência Domiciliar , Prontuários Médicos , Neoplasias/psicologia , Qualidade de Vida , Adulto , Idoso , Idoso de 80 Anos ou mais , Coleta de Dados/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/fisiopatologia
12.
J Orthop Trauma ; 15(4): 287-93, 2001 May.
Artigo em Inglês | MEDLINE | ID: mdl-11371795

RESUMO

OBJECTIVES: To analyze the mechanism of injury for foot and ankle fractures resulting from automobile accidents to create a basis for developing an improved design for protection. DESIGN: Retrospective. SETTING: Level I trauma center with accident research unit. PATIENTS: Automobile accident reports and medical records of individuals injured in the accidents. MAIN OUTCOME MEASUREMENTS: Technical indicators (collision type, impulse angle, deltav, and extent of vehicle deformation) and clinical data (injury location and severity [abbreviated injury scale and injury severity score] and long-term outcome). RESULTS: From 1973 to 1996, 15,559 car accidents were analyzed. Two hundred sixty-one front seat occupants sustained fractures of the foot and ankle (ankle, 41 percent; forefoot, 29 percent; midfoot, 20 percent; and hindfoot, 10 percent). Seventy-five percent of the fractures were classified abbreviated injury scale(foot) 2. The incidence, location, and abbreviated injury scale(foot) category of fractures were similar between driver (n = 210) and front seat passenger (n = 51). Fifty percent of the fractures occurred in head-on collisions and 34 percent occurred in accidents with multiple collisions. The deltav ranged in 82 percent of car crashes between fifteen and sixty kilometers per hour. The deltav and extent of foot compartment deformation correlated with the abbreviated injury scale. During our investigation, deltav increased; the injury severity score decreased; and the extent of deformation did not differ significantly. CONCLUSIONS: Although overall car passenger safety has improved, the relative incidence of foot and ankle fractures has increased. Comparing drivers and front seat passengers, the foot pedals, steering wheel, or the asymmetric design of the dashboard did not influence injury incidence, mechanism, or severity. Foot fractures are mainly caused by the foot compartment deformation in head-on collisions, and therefore improvements in foot compartments are essential for fracture prevention.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Traumatismos do Tornozelo/etiologia , Traumatismos do Pé/etiologia , Fraturas Ósseas/etiologia , Fraturas Ósseas/prevenção & controle , Escala Resumida de Ferimentos , Acidentes de Trânsito/tendências , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Traumatismos do Tornozelo/epidemiologia , Traumatismos do Tornozelo/prevenção & controle , Criança , Pré-Escolar , Avaliação da Deficiência , Feminino , Traumatismos do Pé/epidemiologia , Traumatismos do Pé/prevenção & controle , Fraturas Ósseas/classificação , Fraturas Ósseas/epidemiologia , Humanos , Incidência , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Restrição Física/efeitos adversos , Estudos Retrospectivos , Distribuição por Sexo
13.
Orthopade ; 28(5): 414-423, 1999 May.
Artigo em Inglês | MEDLINE | ID: mdl-28246956

RESUMO

The analysis of 1,176 whiplash-type neck distortions was sought from a total of 3,838 restrained car driver incident reports. The percentage of these injuries increased from less than 10 % in 1985 to over 30 % in 1997. These occurred mostly with head-on or with multiple collisions, and only in 15 % with pure rear-end collisions. In 23,2 %, δv amounted 10 km/h or less, which corresponds to a very minor crash. The average δv was the highest in the cases of head-on collisions. Letters were sent to the injured to find out about the duration and type of complaints caused by a cervical spine injury. Of the 138 patients who returned the questionnaires, 121 (88 %) indicated that they had or were still suffering from their symptoms. Percentage of various complaints were as follows: pain (74 %), tension (6 %) and stiffness (5 %) in the head (27 %), neck (55 %) and shoulder (8 %). The duration of the complaints was longest after multiple collisions and when the onset of complaints was later than 24 hours after trauma. Women and elderly persons predominated slightly in the group with longer duration of complaints. A correlation between the severity of the accompanying injuries and duration of complaints occurred. Also, with this retrospective study there was considerable difficulties in the lack of adequate follow-up for these patients with less severe injuries. In order to better evaluate this problem, prospective studies are necessary which include documentation of diagnosis, treatment protocols, duration and type of complaints.

14.
Artigo em Inglês | MEDLINE | ID: mdl-12361520

RESUMO

This study has considered demands placed on protective clothes for motorcyclists together with observed benefits and limitations for absorbing loads and preventing injuries. In this study, 1933 accidents involving injured motorcyclists, collected by an in-depth investigation team at ARU-MUH, were analysed to find the detailed injury patterns comparing persons with and without protective clothes. The parameters influencing the force reduction are discussed comparing impact speed, elasticity coefficient and thickness of the materials used in special protectors. Additionally, post mortem human tests were carried out to find the effectiveness of such protector devices for load reductions in the lower leg. This study showed that loads, and the subsequent risk of fractures, can be reduced efficiently by foam-plate systems. Benefits were established for using a laminate of hard and soft materials for protection against soft tissue injuries both in the accident analysis and experimental tests.


Assuntos
Acidentes de Trânsito , Traumatismos da Perna/prevenção & controle , Motocicletas , Roupa de Proteção , Adulto , Idoso , Fenômenos Biomecânicos , Fraturas Ósseas/patologia , Fraturas Ósseas/fisiopatologia , Fraturas Ósseas/prevenção & controle , Humanos , Escala de Gravidade do Ferimento , Traumatismos da Perna/patologia , Traumatismos da Perna/fisiopatologia , Pessoa de Meia-Idade , Fatores de Risco
15.
J Contin Educ Nurs ; 24(3): 123-7, 1993.
Artigo em Inglês | MEDLINE | ID: mdl-8408851

RESUMO

Continuing education (CE) opportunities for oncology nurses practicing at an advanced level are difficult to access. This article describes an ongoing educational effort to meet the needs of this target group in a midwestern state. Details of conference planning, implementation, and evaluation are included. A description of the screening process and program content is emphasized. This approach is applicable to a variety of specialty practice areas.


Assuntos
Educação Continuada em Enfermagem/organização & administração , Enfermagem Oncológica/educação , Desenvolvimento de Programas , Currículo , Humanos , Avaliação de Programas e Projetos de Saúde
16.
Br J Pharmacol ; 171(7): 1758-71, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24417347

RESUMO

BACKGROUND AND PURPOSE: The prevalence of smoking in schizophrenia patients is exceptionally high; it is not known why but many researchers suggest that smoking constitutes a form of self-medication. Among the symptoms of schizophrenia that may be improved by nicotine are cognitive deficits. Hence, we studied the effects of long-term nicotine administration on cognition in a genetic animal model of schizophrenia susceptibility, G72-transgenic (G72Tg) mice. EXPERIMENTAL APPROACH: The effect of long-term nicotine or saline, administered by osmotic minipumps, on different cognitive domains was assessed in G72Tg mice and controls using a battery of behavioural tests. To investigate the mechanism underlying phenotypic differences, quantitative autoradiographic mapping of nACh receptor subtypes was performed in forebrain structures to explore effects of chronic nicotine exposure on nACh receptor density in wild-type (WT) and G72Tg mice. KEY RESULTS: Genotype significantly affected the cognitive effects of chronic nicotine administration. Whereas chronic nicotine disrupted cognitive performance in WT mice, it was effective at restoring impaired prepulse inhibition, working memory and social recognition in G72Tg mice. However, long-term spatial learning was further impaired by nicotine in transgenic animals. In contrast, associative learning was protected by G72-expression against the adverse nicotine effects seen in WT animals. G72-expression did not decisively influence nicotine-induced up-regulation of the α4ß2*subtype, whereas α7nACh receptor density was differentially altered by genotype or by a genotype·treatment interaction in specific brain areas, most notably hippocampal subregions. CONCLUSIONS AND IMPLICATIONS: Our data support the hypothesis that nicotine self-medication of schizophrenics improves cognitive symptoms, possibly by facilitating nicotine-induced α7nACh receptor activation in the hippocampus.


Assuntos
Comportamento Animal/efeitos dos fármacos , Memória de Curto Prazo/efeitos dos fármacos , Nicotina/administração & dosagem , Agonistas Nicotínicos/administração & dosagem , Nootrópicos/administração & dosagem , Esquizofrenia/tratamento farmacológico , Psicologia do Esquizofrênico , Animais , Proteínas de Transporte/genética , Proteínas de Transporte/metabolismo , Cognição/efeitos dos fármacos , Modelos Animais de Doenças , Esquema de Medicação , Genótipo , Humanos , Peptídeos e Proteínas de Sinalização Intracelular , Camundongos , Camundongos Transgênicos , Inibição Neural/efeitos dos fármacos , Fenótipo , Prosencéfalo/efeitos dos fármacos , Prosencéfalo/metabolismo , Reconhecimento Psicológico/efeitos dos fármacos , Esquizofrenia/diagnóstico , Esquizofrenia/genética , Comportamento Social , Fatores de Tempo , Receptor Nicotínico de Acetilcolina alfa7/agonistas , Receptor Nicotínico de Acetilcolina alfa7/metabolismo
17.
Burns ; 39(8): 1535-40, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24169314

RESUMO

BACKGROUND: Patients of motor vehicle crashes (MVCs) suffering burns are challenging for the rescue team and the admitting hospital. These patients often face worse outcomes than crash patients with trauma only. Our analysis of the German In-depth Accident Study (GIDAS) database researches the detailed crash mechanisms to identify potential prevention measures. METHODS: We analyzed the 2011 GIDAS database comprising 14,072 MVC patients and compared individuals with (Burns) and without (NoBurns) burns. Only complete data sets were included. Patients with burns obviously resulting of air bag deployment only were not included in the Burns group. Data acquisition by an on call team of medical and technical researchers starts at the crash scene immediately after the crash and comprises technical data as well as medical information until discharge from the hospital. Statistical analysis was done by Mann-Whitney-U-test. Level of significance was p < 0.05. RESULTS: 14,072 MVC patients with complete data sets were included in the analysis. 99 individuals suffered burns (0.7%; group "Burns"). Demographic data and injury severity showed no statistical significant difference between the two groups of Burns and NoBurns. Injury severity was measured using the Injury Severity Score (ISS). Direct frontal impact (Burns: 48.5% vs. NoBurns: 33%; p < 0.05) and high-energy impacts as represented by delta-v (m/s) (Burns: 33.5 ± 21.4 vs. NoBurns: 25.2 ± 15.9; p < 0.05) were significantly different between groups as was mortality (Burns: 12.5% vs. NoBurns: 2.1%; p < 0.05). Type of patients' motor vehicles and type of crash opponent showed no differences. CONCLUSIONS: Our results show, that frontal and high-energy impacts are associated with a frequency of burns. This may serve automobile construction companies to improve the burn safety to prevent flames spreading from the motor compartment to the passenger compartment. Communities may impose speed limits in local crash hot spots.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Queimaduras/epidemiologia , Ferimentos e Lesões/epidemiologia , Adulto , Idoso , Queimaduras/etiologia , Queimaduras/prevenção & controle , Feminino , Alemanha/epidemiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Razão de Chances , Fatores de Risco , Estatísticas não Paramétricas , Índices de Gravidade do Trauma
18.
Accid Anal Prev ; 44(1): 111-7, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22062344

RESUMO

In accidents which involve two-wheeled vehicles the helmet plays a life-saving role, but very little is known about the motorcycle rider's perception of the helmet. We evaluated the relationships between having been involved in an accident and dissatisfaction with the helmet, and between the perception of motorcycle riders and the objective features of the helmet. This was a case-control study: riders of motorized two-wheelers who had been involved in accidents (accident cases) were compared against a similarly interviewed sample of riders that had not been in accidents (control cases). Information about the driver, the vehicle and the helmet was collected in all interviews. To evaluate the relationships, logistic regressions were carried out. The majority of drivers were dissatisfied with their helmets, but no evidence was found to link this dissatisfaction with having been involved in an accident. The two most common complaints related to noisiness, followed by the helmet visor. Complaints did not seem to be statistically associated with physical features of the helmet.


Assuntos
Acidentes de Trânsito/prevenção & controle , Atitude , Dispositivos de Proteção da Cabeça , Motocicletas , Acidentes de Trânsito/psicologia , Adulto , Estudos de Casos e Controles , Desenho de Equipamento , Europa (Continente) , Feminino , Humanos , Modelos Logísticos , Masculino , Análise Multivariada
19.
Z Orthop Unfall ; 148(5): 573-8, 2010 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-20645253

RESUMO

AIM: Quads or all-terrain vehicles do not seem to play a major role either in traffic accidents or in hospital admissions in Germany. However, reports about spectacular quad crashes in the press are not that infrequent. In contrast, no scientific survey or study regarding the issue of quad crashes in Germany has been published so far. Thus, this study aims to evaluate the present incidence of quad crashes, accident circumstances and resulting injury patterns, and to discuss possible consequences. METHOD: At a level I trauma centre, data from accident and hospital records of quad drivers were analysed focusing on the following parameters: injury type, localisation and mechanism, treatment details, abbreviated injury scale (AIS) score, maximum AIS (MAIS) score, delta-v, collision speed, and other technical parameters. Comparisons to motorcycle accidents were performed. RESULT During a five-year period from 2005 to 2009, there were ten admissions of quad drivers out of around 11 000 emergency trauma patients (0.1 %). Five accidents had happened off-road, four were traffic accidents. Eight patients were male; the mean age was 30 years. The mean total hospital stay was 15 days; there was a mean of 1.5 stays per patients with 2.0 surgical procedures needed. One patient died, only two recovered fully. The accident research data bank revealed 14 cases of quad accidents out of 18 990 (0.1 %). The mean impact velocity was 35 km/h (motorcyclists 40.0 km/h). The most frequent injury mechanism was a collision with a car. The upper extremity was the predominant injured region (AIS 0.7), while it was the lower extremity for motorcyclists (AIS0.91). The maximum AIS were 1.4 in quad drivers and 1.49 in motorcyclists. CONCLUSIONS: Although the absolute incidence of quad accidents in Germany is low, they pose a relatively high risk for severe injuries. Possible reasons are the comparatively low active and passive safety of quads as well as limited experience with quad driving and the "fun" aspect which might provoke risky driving behaviour. Larger series from the US report a high incidence of drug abuse among quad casualties as well as very limited use of helmets. In Germany, helmet usage has been mandatory since 2006. Possible additional measures to prevent a rise in quad accidents could be the total prohibition of alcohol consumption for quad drivers as well as special courses or driving licenses or an increase of the legal age for driving quads.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Veículos Off-Road/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Prevalência , Medição de Risco , Fatores de Risco , Adulto Jovem
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