Detalhe da pesquisa
1.
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
Proc Natl Acad Sci U S A
; 121(2): e2309700120, 2024 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38170745
2.
Targeting Biomolecular Condensation and Protein Aggregation against Cancer.
Chem Rev
; 123(14): 9094-9138, 2023 07 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37379327
3.
Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies.
Brain
; 147(1): 81-90, 2024 01 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37526295
4.
The lysosomal ß-glucocerebrosidase strikes mitochondria: implications for Parkinson's therapeutics.
Brain
; 2024 Mar 04.
Artigo
Inglês
| MEDLINE | ID: mdl-38437875
5.
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Proc Natl Acad Sci U S A
; 119(15): e2109617119, 2022 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35353605
6.
In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease.
J Cell Biochem
; 125(3): e30523, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38239037
7.
Altered hippocampal doublecortin expression in Parkinson's disease.
J Neurochem
; 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38485468
8.
Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.
Hum Mol Genet
; 31(21): 3694-3714, 2022 10 28.
Artigo
Inglês
| MEDLINE | ID: mdl-35567546
9.
Regional AT-8 reactive tau species correlate with intracellular Aß levels in cases of low AD neuropathologic change.
Acta Neuropathol
; 147(1): 40, 2024 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38353753
10.
Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice.
Mov Disord
; 2024 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-38576081
11.
Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson's Disease.
Neurochem Res
; 2024 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-38782838
12.
Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments.
Org Biomol Chem
; 22(13): 2670-2676, 2024 03 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38483440
13.
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
PLoS Genet
; 17(3): e1009407, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33657088
14.
Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition.
J Biol Chem
; 298(5): 101848, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35314196
15.
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
J Biol Chem
; 298(5): 101902, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35390347
16.
PrP meets alpha-synuclein: Molecular mechanisms and implications for disease.
J Neurochem
; 2023 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37855859
17.
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease.
J Neurochem
; 2023 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-37381043
18.
Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
J Neurochem
; 2023 Sep 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37661637
19.
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.
J Neurochem
; 166(5): 862-874, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37515330
20.
The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.
Mol Med
; 29(1): 111, 2023 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37596531