Detalhe da pesquisa
1.
Logic-Based and Cellular Pharmacodynamic Modeling of Bortezomib Responses in U266 Human Myeloma Cells.
J Pharmacol Exp Ther
; 354(3): 448-58, 2015 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26163548
2.
A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.
Pharmaceutics
; 16(5)2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38794321
3.
A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK.
AAPS J
; 26(1): 11, 2024 01 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38167740
4.
Enzyme sequence similarity improves the reaction alignment method for cross-species pathway comparison.
Toxicol Appl Pharmacol
; 271(3): 363-71, 2013 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20851138
5.
Pathway modeling of microarray data: a case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP).
Toxicol Appl Pharmacol
; 271(3): 386-94, 2013 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20850466
6.
Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set.
Toxicol Appl Pharmacol
; 271(3): 349-62, 2013 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21745491
7.
Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma.
AAPS J
; 24(6): 100, 2022 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36127472
8.
Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies.
Pharmaceutics
; 14(5)2022 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35631556
9.
Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Mol Cancer Ther
; 21(6): 974-985, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35364611
10.
A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis.
AAPS J
; 24(1): 7, 2021 12 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34862519
11.
Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer.
Mol Cancer Ther
; 20(4): 716-725, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33536191
12.
Circadian signatures in rat liver: from gene expression to pathways.
BMC Bioinformatics
; 11: 540, 2010 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21040584
13.
Transcriptional and metabolic flux profiling of triadimefon effects on cultured hepatocytes.
Toxicol Appl Pharmacol
; 248(3): 165-77, 2010 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20659493
14.
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody.
JCI Insight
; 5(7)2020 04 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32271166
15.
Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development.
Clin Transl Sci
; 11(6): 540-552, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-29877608
16.
Systems pharmacology and enhanced pharmacodynamic models for understanding antibody-based drug action and toxicity.
MAbs
; 9(1): 15-28, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27661132
17.
Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.
MAbs
; 9(2): 213-230, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-27929752