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1.
Mol Pharm ; 21(1): 18-37, 2024 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-38108281

RESUMO

Sartans (angiotensin II receptor blockers, ARBs), drugs used in the treatment of hypertension, play a principal role in addressing the global health challenge of hypertension. In the past three years, their potential use has expanded to include the possibility of their application in the treatment of COVID-19 and neurodegenerative diseases (80 clinical studies worldwide). However, their therapeutic efficacy is limited by their poor solubility and bioavailability, prompting the need for innovative approaches to improve their pharmaceutical properties. This review discusses methods of co-crystallization and co-amorphization of sartans with nonpolymeric, low molecular, and stabilizing co-formers, as a promising strategy to synthesize new multipurpose drugs with enhanced pharmaceutical properties. The solid-state forms have demonstrated the potential to address the poor solubility limitations of conventional sartan formulations and offer new opportunities to develop dual-active drugs with broader therapeutic applications. The review includes an in-depth analysis of the co-crystal and co-amorphous forms of sartans, including their properties, possible applications, and the impact of synthetic methods on their pharmacokinetic properties. By shedding light on the solid forms of sartans, this article provides valuable insights into their potential as improved drug formulations. Moreover, this review may serve as a valuable resource for designing similar solid forms of sartans and other drugs, fostering further advances in pharmaceutical research and drug development.


Assuntos
Bloqueadores do Receptor Tipo 1 de Angiotensina II , Anti-Hipertensivos , Bloqueadores do Receptor Tipo 1 de Angiotensina II/química , Antagonistas de Receptores de Angiotensina/química , Inibidores da Enzima Conversora de Angiotensina/química , Anti-Hipertensivos/química , Solubilidade
2.
Int J Mol Sci ; 25(3)2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38339017

RESUMO

The reaction of (ortho-acetalaryl)arylmethanols with various phosphines PR1R2R3 (R1 = R2 = R3 = Ph; R1 = R2 = Ph, R3 = Me and R1 = R2 = Me, R3 = Ph) under acidic conditions (e.g., HCl, HBF4, TsOH) unexpectedly led to the formation of (10-hydroxy-9,10-dihydroanthr-9-yl)phosphonium salts instead of the corresponding anthryl phosphonium salts. The cyclization occurred according to the Friedel-Crafts mechanism but without the usually observed Bradsher dehydration, giving cyclic products in the form of cis/trans isomers and their conformers. In case of electron-rich and less-hindered dimethylphenylphosphine, all four stereoisomers were recorded in 31P{1H} NMR spectra, while for the other phosphines, only the two most stable cis/trans stereoisomers were detected. This study was supported by DFT and NCI calculations in combination with FT-IR analysis.


Assuntos
Fosfinas , Sais , Humanos , Estrutura Molecular , Ciclização , Desidratação , Espectroscopia de Infravermelho com Transformada de Fourier , Fosfinas/química
3.
Molecules ; 29(15)2024 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-39125096

RESUMO

This review focuses on optical properties of compounds in which at least one phosphonate group is directly attached to a heteroaromatic ring. Additionally, the synthesis and other applications of these compounds are addressed in this work. The influence of the phosphonate substituent on the properties of the described compounds is discussed and compared with other non-phosphorus substituents, with particular attention given to photophysical properties, such as UV-Vis absorption and emission, fluorescence quantum yield and fluorescence lifetime. Considering the presence of heteroatom, the collected material was divided into two parts, and a review of the literature of the last thirty years on heteroaryl phosphonates containing sulfur and nitrogen atoms in the aromatic ring was conducted.

4.
Molecules ; 28(6)2023 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-36985445

RESUMO

This paper presents the use of O,S-acetals in a new modification of the oxo-Friedel-Crafts-Bradsher cyclization. In this reaction, under mild reaction conditions (25 °C), three- and four-ring fused RO-acenes (major) and/or HO(CH2)2S-acenes (minor) are formed, the latter products having never been observed before in this type of cyclization. In this way, two electronically different fluorophores could be obtained in a single cyclization reaction, one of them having strong electron donor properties (+M effect of alkoxy groups) and the other having donor-acceptor properties (+M and -I effects of the HO(CH2)2S-group, Hammett's constants). Further increasing the reaction temperature, HCl concentration or prolonging reaction time, surprisingly, yielded a 2:1 mixture of cis and trans dimeric isomers, as the only products of this cyclization. The DFT calculations confirmed a greater stability of the cis isomer compared to the trans isomer. The formation of unexpected dimeric products and HO(CH2)2S-acenes sheds light on the mechanism of oxo-Friedel-Crafts-Bradsher cyclization, involving competitive O/S atom protonation in strained O,S-acetals and in strain-free side groups of intermediate species.

5.
Molecules ; 27(19)2022 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-36235148

RESUMO

This comprehensive review, covering the years 1968-2022, is not only a retrospective investigation of a certain group of linearly fused aromatics, called acenes, but also a presentation of the current state of the knowledge on the synthesis, reactions, and applications of these compounds. Their characteristic feature is substitution of the aromatic system by one, two, or three organophosphorus groups, which determine their properties and applications. The (PIII, PIV, PV) phosphorus atom in organophosphorus groups is linked to the acene directly by a P-Csp2 bond or indirectly through an oxygen atom by a P-O-Csp2 bond.


Assuntos
Benzeno , Fósforo , Oxigênio/química , Fósforo/química , Estudos Retrospectivos
6.
Molecules ; 26(8)2021 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-33924691

RESUMO

Amygdalin (d-Mandelonitrile 6-O-ß-d-glucosido-ß-d-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical evidence for the anticancer activity of amygdalin is not fully confirmed. Moreover, high dose exposures to amygdalin can produce cyanide toxicity. The aim of this review is to present the current state of knowledge on the sources, toxicity and anticancer properties of amygdalin, and analytical methods for its determination in plant seeds.


Assuntos
Amigdalina/química , Glicosídeos/química , Cianeto de Hidrogênio/química , Sementes/química , Animais , Humanos
7.
Chemistry ; 25(62): 14148-14161, 2019 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-31432602

RESUMO

The highly substituted mono-aryl/alkylthio-(hetero)acenes prepared in this study have been found to be thermally more stable (Tdecomp. =331-354 °C) than the known di-aryl/alkylthio-substituted acenes by an average of 25 °C. They are also much more photostable at 254 and 365 nm (in both argon and air) than the parent anthracene and other reported anthracenes. The most photostable aryl/alkylthio-anthracenes at 254 nm were found to be 60-70 (in air) and 130 (in argon) times more stable in solution than the unsubstituted anthracene, and much more stable than known EDG/EWG-substituted anthracenes (EDG=electron-donating group, EWG=electron-withdrawing group) with an extended aromatic core. Furthermore, the acenes showed significantly higher photostability at 365 nm in both air and argon. The anthracenes were obtained by the novel thio-Friedel-Crafts/Bradsher cyclization reaction of hitherto unknown [o-(1,3-dithian-2-yl)aryl](aryl)methyl thioethers. The developed approach provides a general access to mono-aryl/alkylthio-substituted (hetero)acene frameworks containing at least three fused (hetero)aromatic rings. The characteristic feature of this approach, which leads to highly substituted acenes, is that the substituents, unlike in other methods, may be introduced at an early stage of the synthesis. DFT and TD-DFT calculations confirmed the stabilizing role of the aryl/alkylthio substituent in the mono-aryl/alkylthio-substituted anthracenes, which are the most stable anthracenes prepared to date. Their high photostability is mainly due to the quenching of singlet oxygen by the acene and the quenching of the acene S1 state by molecular oxygen.

8.
J Org Chem ; 84(5): 2619-2625, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30698971

RESUMO

The first solvent- and catalyst-free procedure for the Michaelis-Arbuzov reaction under flow conditions was developed. A variety of alkylphosphonic esters could be obtained using this protocol starting from the corresponding trialkyl phosphites and even catalytic amounts of alkyl halides with very short reaction times (8.33-50 min) and excellent conversions. In general, this protocol works effectively when the alkyl halide is used in catalytic amounts as low as 5-10% only if it concerns the synthesis of homo alkylphosphonates. One equivalent and an excess of alkyl halides should be used in the reaction with alkyl phosphite if the alkyl group of the selected substrates differ. Thus, it provides a sustainable, fast alternative to the existing methods for the preparation of alkylphosphonates. The isolation of the reaction products is straightforward due to the lack of solvents and a high purity of the obtained products (conv ≥ 99%), and notably, in the catalytic procedures there are only traces of alkyl halides formed after the reaction is complete. The reactions conducted using a glass microreactor chip with an internal volume of 250 µL allow the production of 1.6-1.95 g of organophosphorus esters per hour.

9.
Beilstein J Org Chem ; 14: 1229-1237, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29977391

RESUMO

We present a successful deoxygenation reaction of ortho-1,3-dithianylaryl(aryl)methanols which enables a selective removal of the secondary hydroxy group in presence of the 1,3-dithianyl moiety under reductive conditions. This reaction proceeds well with ZnI2/Na(CN)BH3 in dichloroethane or benzene for both unsubstituted and substituted aryls (by electron-rich groups). This is leading to formyl-protected diarylmethanes with potential application in the synthesis of new pharmaceuticals and optoelectronic materials. This synthetic approach gives an access to a wide variety of functionalized ortho-1,3-dithianylaryl(aryl)methanes in 26-95% yields and is recommended for the substrates containing sulfur atoms, for which transition metal-induced reactions fail.

10.
Org Biomol Chem ; 14(5): 1822-30, 2016 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-26750755

RESUMO

In this paper, we have described the first total synthesis of (±)-epithuriferic acid methyl ester from non-natural sources, in four steps (20% overall yield). The key step involves the Diels-Alder reaction of isobenzofuran with methyl 3-(dimethoxyphosphoryl)acrylate which is controlled by "ortho" regio- and endo stereoselectivities due to the COOMe group.


Assuntos
Benzofuranos/química , Carbazóis/síntese química , Reação de Cicloadição , Naftalenos/síntese química , Carbazóis/química , Estrutura Molecular , Naftalenos/química , Estereoisomerismo
11.
Materials (Basel) ; 14(13)2021 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-34201740

RESUMO

While few studies show only symmetrical and poorly mono-SOn (n = 0-2) substituted acenes, in this study, we present a synthesis of a new group of unsymmetrical, significantly substituted derivatives, which revealed unique photophysical properties. Both sulfides (S), sulfoxides (SO) and sulfones (SO2) showed very high photochemical stabilities, unusual for these groups, during UV-irradiation at 254/365 nm (air O2 and Ar), which was higher than any found in the literature. For the (S)/(SO) series (254 nm), the stabilities of 80-519 min. (air O2 and Ar) were found. At 365 nm, stabilities of 124-812 min./(air O2) for (S)/(SO) and higher for (SO2) were observed. Photoluminescence lifetimes of (SOn) of the lower anthryl symmetry remained in the following order: (SO2) < (S) < (SO); those with full symmetry were in the following order: (S) < (SO) < (SO2). The enhanced photostability was explained with DFT/MS/Hammett's constants, which showed the leading role of the SOn groups in stabilization of HOMO/LUMO frontier orbitals. The SOn (n = 0-2) substituted acenes turned out to be tunable violet/blue/green emitters by oxidation of S atoms and the introduction of rich substitution.

12.
J Hazard Mater ; 399: 122839, 2020 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-32526424

RESUMO

Increasing consumption of angiotensin II receptor blockers (ARBs: valsartan, losartan potassium, telmisartan) is inevitably associated with their appearance in the environment and impact on aquatic and terrestrial organisms. Since the pharmaceuticals do not occur as pure substances in the environment, but as complex mixtures with other active pharmaceutical ingredients (APIs) and excipients used in pharmaceutical formulations, we compared the ecotoxicity of ARBs in various forms: as pure APIs, in pharmaceutical formulations and in mixtures with hydrochlorothiazide (HCT). Because the studied APIs are poorly water-soluble, the Microtox® Basic Solid Phase Test, utilizing bacteria Aliivibrio fischeri, has been modified by using a neutral matrix. Thus, this test, which is correlated with other tests for higher aquatic organisms, may be applied for the ecotoxicological evaluation of poorly soluble APIs. This is the first study reflecting the real situation in the environment, where non-target species are exposed to the pharmaceuticals, which can be dissolved/suspended in the liquid medium or adsorbed on the solid matrix. The results obtained indicate that the excipients are not inert substances and their presence in the environment may cause an increased risk to non-target organisms. Moreover, antagonistic effects were observed for two-component drug-drug (ARBs-HCT) mixtures.


Assuntos
Preparações Farmacêuticas , Poluentes Químicos da Água , Antagonistas de Receptores de Angiotensina , Inibidores da Enzima Conversora de Angiotensina , Anti-Hipertensivos/toxicidade , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade
13.
J Hazard Mater ; 382: 121086, 2020 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-31465943

RESUMO

Phenoxyacetate herbicides, such as 2,4-D and MCPA, having a high toxicity to non-target organisms are commonly used for controlling broadleaf weeds in agriculture. However, novel and environmentally friendly analogs are constantly sought after. For this purpose, various substituents at the phenyl group have been tested to find the optimal balance between the potent herbicidal activity and safety for non-target species. In this work, we investigated the influence of the oxygen by sulfur replacement in the phenoxy moiety of ammonium chlorophenoxyacetates on the toxicity towards aquatic organisms, such as bacteria (Vibrio fischeri), water flea (Daphnia magna) and freshwater fish (Pimephales promelas) by determining experimental (Microtox® test - V. fischeri) and predicted (ACD Lab Percepta software - D. magna, P. promelas) EC50/LC50 values. The achieved results showed that in contrary to the literature observations, where O-compounds were more toxic than their S-analogs (urea/thiourea), the O/S replacement in chlorophenoxyacetate significantly increased ecotoxicity of the S-analogs (up to 11 times). Moreover, one- and two-substituted phenoxyacetates in the form of ammonium salts were less toxic to V. fischeri than the commercially available phenoxy herbicides in the acid form. The logP/logD values were also calculated to understand hydro/lipophilic nature of the investigated compounds and differences in their toxicity.


Assuntos
Aliivibrio fischeri/efeitos dos fármacos , Compostos de Amônio/toxicidade , Cyprinidae , Daphnia/efeitos dos fármacos , Herbicidas/toxicidade , Fenoxiacetatos/toxicidade , Poluentes Químicos da Água/toxicidade , Aliivibrio fischeri/metabolismo , Compostos de Amônio/química , Animais , Herbicidas/química , Dose Letal Mediana , Luminescência , Oxigênio/química , Fenoxiacetatos/química , Enxofre/química , Poluentes Químicos da Água/química
14.
Ultrason Sonochem ; 58: 104640, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31450342

RESUMO

Two heteroatom-variants of the Friedel-Crafts/Bradsher cyclization of o-acetalaryl(aryl)methyl ethers and o-dithioacetalaryl(aryl)methyl thioethers, have been realized with the ultrasound assistance. The environmentally friendly "oxo-variant" (Oxo-F-C/B), proceeding in a medium containing mineral acid and a large amount of water (HClaq/CH3CN) led to a very efficient formation of RO-substituted (hetero)acenes in less than 5 min. In the "thio-variant" (Thio-F-C/B), o-dithioacetalaryl(aryl)methyl thioethers underwent ultrasound-assisted cyclization in nonaqueous medium (FeCl3/KI/EtOH) in less than 25 min., in lower yields than in the "oxygen variant" to give RS-substituted (hetero)acenes. The RO-(hetero)acenes cyclized at 25-60 °C in aqueous media but did not cyclize in organic solvents while the RS-(hetero)acenes required higher temperatures 55-60 °C and cyclized in organic solvents but did not react in aqueous media. The acceleration of the ultrasound-assisted reactions compared to the reactions carried out under silent conditions exceeded 7500 times in the most effective example of the oxo-variant and on average 2 times for the thio-variant. The plausible reaction mechanisms under ultrasound and silent conditions have been proposed. The ultrasonic mechanism involves disturbing of solvation layers and formation of the reactive ("naked") carbocations upon operation of the shock wave produced by the bubble collapse. The o-acetalaryl(aryl)methyl ethers underwent a selective ultrasound-assisted deacetalization to give o-formylaryl(aryl)methyl ethers, without subsequent cyclization under the acidic reaction conditions.

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