High estradiol levels and depth of anaesthesia.

Estradiol is a steroid-structured hormone that has a periodic rhythm in the menstrual cycle. We aimed to evaluate the interference of high estradiol levels and the depth of anaesthesia. The study was performed on 44 females undergoing gynaelocologic surgery. Blood samples were performed for estradiol level before the procedures. BIS scores were recorded at 5-min intervals after induction and during the operation. Cases were assigned to three groups: Group 1 (n: 17) estradiol levels at or under 100 microg/dl, Group 2 (n: 14) levels were between 100 and 200 microg/dl and Group 3 (n: 13) levels were above 200 microg/dl. Estradiol levels were found to be 59.94 +/- 23.59 microg/dl in Group 1, 138.60 +/- 23.49 microg/dl in Group 2 and 239.30 +/- 41.08 microg/dl in Group 3. Significant differences were found between initial control and 10 and 80 min BIS levels. Anaesthetic consumption showed a decreased tendency in high estradiol cases. We concluded that an advanced clinical series should be performed to fully define the relationship between estradiol levels and anaesthesia depth.

Congenital vulvar teratoma in a newborn.

The most common site of teratomas in neonates is in the sacrococcygeal region. Herein the authors describe a congenital teratoma, and to their knowledge it is the first reported case of vulvar site in a newborn. Tumor was removed on the fourth day of life, and she was completely normal 18 months after the operation. Because of possible malignancy or recurrence, complete surgical excision of the tumor and careful follow-up is the treatment of choice. J Pediatr Surg 36:620-621.

The effect of lidocaine/prilocaine cream on an experimental wound healing model.

The effects of lidocaine/prilocaine cream on wound healing were evaluated in this study. An incisional wound model on abdominal wall was performed on mice. A full thickness skin incision 2 cm in length was performed then it was sutured primarily with 4/0 polypropylene. In group I (n = 10) only suturing was done (control group), in group II (n = 10) lidocaine cream was applied after suturing on wound site and it was repeated for 6 days (twice in a day), in group III (n = 10) lidocaine/prilocaine cream was applied topically after suturing and repeated 6 days (twice in a day). At day 7, incisions were excised for evaluating tensile strength and 5-hydroxyproline (5-HP) values. Tensile strength values were lowest in control group and highest in lidocaine/prilocaine treatment group. 5-HP values were also expressed the same results. Both tensile strength and 5-HP values increased significantly in treatment groups in regard to the control (p < 0.05). It was concluded that lidocaine/prilocaine cream as topical anaesthetic agent had no adverse effect in an incisional wound model, furthermore it may have some beneficial effects on wound healing which remains to be evaluated and it can be used safely in day-to-day emergency practices.

Parathyroid agenesis: prenatal ultrasonographic features and pathological findings.

We report a girl with parathyroid agenesis. The gross anomaly of the long bones was diagnosed prenatally by ultrasound. Pregnancy was terminated at 24 weeks of gestation. There were no other apparent system anomalies except parathyroid gland agenesis and long bone abnormalities. This case is the first reported case of parathyroid agenesis with normal thyroid glands and other systems.