Anti-asthmatic prescription variability in children according to age.

INTRODUCTION: There is little research in the Spanish paediatric population about the consumption of anti-asthmatic agents. The aim of this study was to describe the current pattern of anti-asthmatic drug prescription in the paediatric population from a region of Spain, using the prescribed daily dose as a unit of measurement. METHODS: We analysed the requirements of R03 therapeutic subgroup (anti-asthmatic agents) in children less than 14 years of age in the Public Health System of Castilla y León from 2005 to 2010. Consumption data are presented in prescribed daily doses per thousand inhabitants per day (PDHD) and compared with defined daily doses per thousand inhabitants per day (DHD). RESULTS: 394 876 prescriptions of anti-asthmatics were given to a population of 1 580 229 persons/year. Bronchodilators, leukotriene receptor antagonists, single inhaled corticosteroids (ICS) and long-acting ß2-adrenergics associated with inhaled corticosteroids were the most commonly prescribed drugs: 7.5, 5.2, 4.9 and 2.2 PDHD, respectively. The maximum prescription of bronchodilators (15.9 PDHD/9.8 DHD) occurred in children under 12 months, with montelukast (8.9 PDHD/3.6 DHD) and single inhaled corticosteroids (7.9 PDHD/2.9 DHD) at one year of age. CONCLUSIONS: Between 2005 and 2010, children under four years received a high prescription of anti-asthmatic drugs. The use of maintenance therapy was poorly aligned with the recommendations of asthma guidelines. The PDHD was more accurate for measuring consumption than DHD, especially in younger children.

May cannabinoids prevent the development of chemotherapy-induced diarrhea and intestinal mucositis? Experimental study in the rat.

BACKGROUND: The antineoplastic drug 5-fluoruracil (5-FU) is a pirimidine analog, which frequently induces potentially fatal diarrhea and mucositis. Cannabinoids reduce gastrointestinal motility and secretion and might prevent 5-FU-induced gut adverse effects. Here, we asked whether cannabinoids may prevent diarrhea and mucositis induced by 5-FU in the rat. METHODS: Male Wistar rats received vehicle or the non-selective cannabinoid agonist WIN 55,212-2 (WIN; 0.5 mg kg-1 injection-1 , 1 injection day-1 , 4 consecutive days) by intraperitoneal (ip) route; on the first 2 days, animals received also saline or 5-FU (150 mg kg-1 injection-1 , cumulative dose of 300 mg kg-1 ). Gastrointestinal motor function was radiographically studied after barium contrast intragastric administration on experimental days 1 and 4. Structural alterations of the stomach, small intestine and colon were histologically studied on day 4. PAS staining and immunohistochemistry for Ki67, chromogranin A and CD163 were used to detect secretory, proliferating, and endocrine cells, and activated macrophages respectively. KEY RESULTS: As shown radiographically, 5-FU induced significant gastric emptying delay (on days 1 and 4) and diarrhea (on day 4). WIN did not significantly alter the motility curves obtained for either control or 5-FU-treated animals but tended to reduce the severity of 5-FU-induced diarrhea and increased permanence of barium from day 1 to the beginning of day 4 in 5-FU-treated animals. 5-FU-induced mucositis was severe and not counteracted by WIN. CONCLUSIONS AND INFERENCES: 5-FU-induced diarrhea, but not mucositis, was partly prevented by WIN at a low dose. Cannabinoids might be useful to prevent chemotherapy-induced diarrhea.

X-ray analysis of gastrointestinal motility in conscious mice. Effects of morphine and comparison with rats.

BACKGROUND: Non-invasive methods to study gastrointestinal (GI) motility are of high interest, particularly in chronic studies. Amongst these, radiographic techniques after contrast intragastric administration may offer many advantages. In previous studies, we have successfully and reproducibly applied these techniques together with a semiquantitative analysis method to characterize the effect of different drugs, acutely or repeatedly administered in rat models, but we have never before used these techniques in mice. These are very convenient in basic research. Our aim was to determine if our method is also valid in mice. Additionally, we determined the effect of morphine on GI motor function in both species. METHODS: Animals received an intraperitoneal administration of morphine (at 10 and 5 mg/kg for rats and mice, respectively). Twenty min later, barium contrast (at 2 g/mL) was gavaged (2.5 and 0.4 mL for rats and mice respectively) and serial X-rays were obtained 0-8 h after contrast. X-rays were analyzed as previously described, using a semiquantitative score to build motility curves for each GI region. KEY RESULTS: Motility was much faster in mice than in rats for all GI regions. Morphine at the doses used significantly depressed motility in both species to a similar extent if the whole gut or the upper GI regions (stomach, small intestine) were considered, although its effect seemed to be more intense in the lower GI regions (caecum, colorectum) in rats than in mice. CONCLUSIONS & INFERENCES: We have validated our X-rays method for its use in mice.

Percepción de los pediatras de Atención Primaria de su relación con la Pediatría Hospitalaria / Perception of the Primary Care pediatricians of their relationship with Hospital Pediatrics

Objetivo. El objetivo de este trabajo es conocer la percepción que tienen los pediatras de Atención Primaria (PAP) de Castilla y León de su relación con la Pediatría Hospitalaria. Población y métodos. Se realizó una encuesta entre los pediatras de Atención Primaria para conocer la relación entre niveles asistenciales en las 11 áreas sanitarias de la Comunidad. El cuestionario es anónimo y consta de 16 preguntas en dos bloques: 9 sobre “cómo es/cómo percibimos la relación entre los PAP y el hospital” (bloque 1) y 7 sobre “qué cosas son importantes para los PAP/qué se pide al hospital” (bloque 2). Se puntúa con una escala Likert de 1 (nada) a 5 (máximo). Resultados. Respondieron 134 pediatras (84% mujeres). El 64% tiene 15 años de experiencia en PAP. El 77% trabajan como pediatras de equipo, y el 64% en centros urbanos. El 43% tiene cupos de 800-999 pacientes. El 24% son tutores de apoyo MIR y el 24% colabora en la formación de estudiantes de Medicina. En el primer bloque de preguntas se observan medianas entre 2 y 4 de puntuación Likert, y en el segundo bloque los valores son más elevados (mediana 4). Encontramos diferencias significativas al comparar las respuestas por áreas sanitarias, en todas las preguntas del primer bloque y en la mayoría del segundo. Conclusión. La relación entre niveles es aceptable en su conjunto, con importantes diferencias entre áreas sanitarias (AU)

Objective. To know the perception that Primary Care pediatricians (PCP) of Castilla y Leon have about their relationship with hospital pediatricians. Population and methods. A survey was conducted among PCP to find out the relationship between healthcare levels in the 11 health areas of the Community. The questionnaire is anonymous and consists of 16 questions (two blocks): 9 about “how is/how we perceive the relationship between the PCP and the hospital” (first block) and 7 about “what is important for the PCP/what is asked to the hospital” (second block). It is scored on a Likert scale from 1 (not at all) to 5 (maximum). Results. 134 pediatricians answer (84% women). 64% have 15 years of experience as PCP. 77% work as team pediatrician, and 64% in urban settings. 43% attends 800-999 patients. 24% are support tutors and 24% are trainers of medical students. Medians between 2 and 4 of Likert scores are observed in the first block of questions, and values are higher (4) in the second one. We find significant differences when making comparisons by Health Areas in all the questions in the first block and in most of them in the second. Conclusión. The relationship between healthcare levels is acceptable as a whole with important differences among health areas (AU)

[Paediatric prescribing of anti-asthmatics in primary care in Castilla-León. Geographical variability]. / Prescripción pediátrica de fármacos antiasmáticos en atención primaria en Castilla y León. Variabilidad geográfica.

INTRODUCTION AND OBJECTIVES: Asthma is one of the most prevalent chronic diseases with effective treatment in paediatrics. The aim of this study is to describe the paediatric prescribing of anti-asthmatics in Castilla-León, analyzing its geographic variability and temporal evolution. MATERIAL AND METHODS: An analysis was made of prescriptions dispensed in pharmacies of R03 therapeutic subgroup (anti-asthmatic agents), and the active ingredients mepyramine and ketotifen, prescribed in children less than 14 years of age in the Castilla-León health service from 2005 to 2010 in Primary Care. Data is presented in prescribed daily doses per thousand inhabitants per day (PDHD) for each active ingredient being calculated raw rates and age-adjusted to the variables health area, type of health zone and year of study. RESULTS: A total of 462,354 prescriptions of anti-asthmatic agents were dispensed to a population of 1,580,229 persons/year. There was wide variation between areas in the type and intensity of anti-asthmatic agents used, partly explained by differences in the prevalence of asthma. Montelukast predominated as controller drug in most of them (PDHD 3.1 to 7.7), being similar the consumption intensity in the three types of health zones (PDHD 4.7 to 4.8). The annual variability was low. CONCLUSIONS: The study describes the paediatric prescribing pattern of anti-asthmatic agents in Castilla-León between 2005-2010. It shows wide geographical variation, as well as inadequacies regarding current recommendations of asthma treatment.

Struvite crystal precipitation by different phenotypes of Yersinia.

Extracellular formation of struvite crystals by Yersinia enterocolitica, Y. frederiksenii, Y. kristensenii and Y intermedia strains was investigated. Precipitation of crystalline structures was found with 19 of the 187 strains tested, its formation being more frequently observed at 25 degrees C than at 37 degrees C. Production of struvite was greater in Y. enterocolitica strains belonging to biotype 1, serogroup 0:7,8 and lysotype Xz, than observed in other phenotypes. Quantitative assay in a liquid medium showed that struvite formation began after 3 d of incubation; production of these crystals increased up to 15 d. Crystalline structures were examined using electron microscopy and their extracellular formation was observed.

[Tobacco, infant feeding, and wheezing in the first three years of life]. / Tabaco, lactancia y sibilantes en los primeros tres años.

BACKGROUND: Wheezing lower respiratory tract diseases are frequent and troublesome in young children. However, the only avoidable risk factors for them are tobacco smoke exposure and feeding practices. OBJECTIVE: To measure the influence of these avoidable factors on the risk of wheeze in the first 3 years of life. METHODS: We performed a population study including all the children born between January 1998 and November 2002 who were attended in the same primary health center in Palencia (Spain) from birth. Information on family history, pregnancy, delivery, and smoking was obtained soon after birth. Feeding practices were recorded on monthly visits. Wheezing episodes in the first 3 years of life were identified by a pediatrician. RESULTS: Two hundred thirty-four children were included and 43 had at least one episode of wheezing. The results were adjusted by sex, prematurity, a family history of allergy, having older siblings, maternal age, and month of birth. No association was found between wheezing and exclusive breast feeding for 3 months (hazard ratio [HR] 5 0.83, 95 % CI: 0.42-1.64), or with postnatal exposure to tobacco smoke (HR 5 1.2, 95 % CI: 0.45-2.34). Tobacco smoke exposure during pregnancy was associated with a higher risk of wheezing: HR 5 2.54 (95 % CI: 1.18-5.48). CONCLUSIONS: Prenatal exposure to tobacco smoke is the main modifiable risk factor for wheezing diseases in the first 3 years of life.

[Prescription of systemic cold and cough drugs to children 0-13 years old. An unresolved problem]. / Prescripción de fármacos anticatarrales de uso sistémico a niños de 0-13 años. Un problema no resuelto.

INTRODUCTION AND OBJECTIVES: Upper respiratory tract infections are the most common cause of paediatric consultation, generating a high volume of prescriptions of drugs with unfavourable risk-benefit ratio. The aim of this study is to describe the prescription of systemic cough and cold medicines to children under 14 years of age in Castilla y León and analyse its variability. POPULATION AND METHODS: A count was made of the prescriptions for the R05 therapeutic subgroup (antitussives and mucolytics) and the R01B pharmacological therapeutic subgroup (nasal decongestants for systemic use), prescribed for children under the age of 14 in the Public Health System between 2005-2010. The number of prescriptions was analysed as crude and age-adjusted rates, as well as a a multivariate analysis (Poisson regression) of the variability associated with health area, the urban/rural environment, age, and year of prescription. RESULTS: There were 806,785 prescriptions for systemic cough and cold drugs given to an exposed population of 1,580,229 person-years. Prescription rates (per 100 person-years) were 20.7 (antitussives), 7.0 (sympathomimetic) and 23.4 (mucolytics). These drugs were employed more often in children <4 years. The prescription of mucolytics and sympathomimetics was highest at age of 1 year (rates=41.9 and 18.7, respectively) and of antitussives at 3 years (35.7). Multivariate analysis showed that in rural areas the prescription was higher than in urban areas, and that there were also significant differences between health areas. CONCLUSIONS: Between 2005 and 2010 there was a high prescription of systemic cough and cold medicines, especially in children under 2 years old, and often outside the recommended conditions of use, and there was a high geographic variabilty.

Caracterización fluoroscópica en rata de la dismotilidad colónica asociada a tratamiento con morfina / Fluoroscopic characterization of colonic dysmotility in rat associated with morphine treatment

No disponible

[Determining factors of physical activity level in school children and adolescents: the OPACA study]. / Determinantes del nivel de actividad física en escolares y adolescentes: estudio OPACA.

INTRODUCTION: Physical activity is a key factor for human health. This study attempts to measure the level of physical activity in children and to find out what are the factors that determine it. METHOD: In a sample of the 11 and 14 year-old population of the centre-south area of Palencia, physical activity was measured using a three day diary, and anthropometric and socioeconomic variables were collected. Three variables were analysed: fat-free mass adjusted activity energy expenditure (AEE/FFM), physical activity level (PAL), and categorical physical activity (active/inactive). RESULTS: A total of 179 children were included, of whom 71.5% were active or very active. Males were more active than females, and activity was also higher in summer. Physical activity declined between 11 and 14 years, and was lower during the weekends than in working days. There were no differences related to obesity, overweight or percent body fat. More active children had lower blood pressure. Physical activity was directly related to weekly hours spent in sport activities, and inversely related to time spent on sedentary activities. Multivariate analysis showed that children from families with low educational levels had a higher activity level not related to sport activities. CONCLUSIONS: The level of physical activity in this population is acceptable, although there are sex differences and there is a declining trend through the adolescence.

Prescripción pediátrica de fármacos antiasmáticos en atención primaria en Castilla y León. Variabilidad geográfica / Paediatric prescribing of anti-asthmatics in primary care in Castilla-León. Geographical variability

INTRODUCCIÓN Y OBJETIVOS: El asma es una de las enfermedades crónicas con tratamiento eficaz más prevalentes en pediatría. El objetivo de este trabajo es describir la prescripción pediátrica de antiasmáticos en Castilla y León, analizando su variabilidad geográfica y su evolución temporal. MATERIAL Y MÉTODOS: Se estudiaron las prescripciones dispensadas en farmacias del subgrupo terapéutico R03 (medicamentos antiasmáticos) y de los principios activos mepiramina y ketotifeno, realizadas a menores de 14 años en atención primaria en el Sistema Nacional de Salud entre 2005 y 2010. Los datos se presentan en dosis diarias prescritas por 1.000 habitantes/día (PDHD) para cada principio activo, calculándose tasas crudas y ajustadas por edad para las variables área sanitaria, tipo de zona de salud y año del estudio. RESULTADOS: Se realizaron 462.354 prescripciones de antiasmáticos a una población expuesta de 1.580.229 personas-año. Hubo amplia variabilidad entre las áreas en el tipo e intensidad de los antiasmáticos utilizados, en parte explicada por diferencias en su prevalencia de asma. Montelukast predominó como fármaco controlador en la mayoría de ellas (3,1-7,7 PDHD), siendo su intensidad de consumo similar en los 3 tipos de zonas de salud (4,7-4,8 PDHD). La variabilidad anual fue escasa. CONCLUSIONES: El estudio describe el patrón pediátrico de prescripción de antiasmáticos en Castilla y León entre 2005 y 2010. Muestra gran variabilidad geográfica, así como inadecuaciones respecto a las recomendaciones actuales de tratamiento del asma

INTRODUCTION AND OBJECTIVES: Asthma is one of the most prevalent chronic diseases with effective treatment in paediatrics. The aim of this study is to describe the paediatric prescribing of anti-asthmatics in Castilla-León, analyzing its geographic variability and temporal evolution. MATERIAL AND METHODS: An analysis was made of prescriptions dispensed in pharmacies of R03 therapeutic subgroup (anti-asthmatic agents), and the active ingredients mepyramine and ketotifen, prescribed in children less than 14 years of age in the Castilla-León health service from 2005 to 2010 in Primary Care. Data is presented in prescribed daily doses per thousand inhabitants per day (PDHD) for each active ingredient being calculated raw rates and age-adjusted to the variables health area, type of health zone and year of study. RESULTS: A total of 462,354 prescriptions of anti-asthmatic agents were dispensed to a population of 1,580,229 persons/year. There was wide variation between areas in the type and intensity of anti-asthmatic agents used, partly explained by differences in the prevalence of asthma. Montelukast predominated as controller drug in most of them (PDHD 3.1 to 7.7), being similar the consumption intensity in the three types of health zones (PDHD 4.7 to 4.8). The annual variability was low. CONCLUSIONS: The study describes the paediatric prescribing pattern of anti-asthmatic agents in Castilla-León between 2005-2010. It shows wide geographical variation, as well as inadequacies regarding current recommendations of asthma treatment

Prescripción off-label de antiasmáticos en Atención Primaria / Off-label prescription of anti-asthmatic agents in Primary Care

Introducción y objetivos: se denomina prescripción off-label a la realizada fuera de las condiciones autorizadas en la ficha técnica de un medicamento. En Atención Primaria se publican cifras globales de prescripción off-label en diferentes países del 3-67%. El objetivo del estudio ha sido conocer la intensidad de este tipo de prescripción en el caso de los antiasmáticos en un periodo reciente, en Castilla-León (España). Métodos: se analizaron las prescripciones correspondientes al subgrupo terapéutico R03 (medicamentos para enfermedades obstructivas respiratorias) realizadas a menores de 14 años entre 2005-2010 en el sistema público de salud autonómico. La información sobre el uso off-label se presenta en número de prescripciones consumidas de antiasmáticos a dosis y/o edades no recomendadas en su ficha técnica. Resultados: se realizaron 394876 prescripciones de antiasmáticos a una población expuesta de 1 580229 personas/año. Los menores de cuatro años fueron los que más antiasmáticos recibieron. La máxima prescripción de broncodilatadores ocurrió en menores de dos años, la de montelukast y corticoides inhalados monofármaco al año de edad. El 46% de las prescripciones de salbutamol sistémico y el 15,9% de las de la terapia de mantenimiento se prescribieron off-label. Conclusiones: el estudio muestra un uso importante de antiasmáticos a edades muy tempranas en las que es difícil hacer el diagnóstico de asma y un consumo notable de fármacos controladores a dosis y/o edades no autorizadas. La prescripción off-label no presupone una prescripción inadecuada, pero debería tener un beneficio real para el paciente y estar apoyada por avales científicos que justifiquen su uso (AU)

Introduction and objectives: off-label prescribing is when performed outside of the official information of the product. Overall figures of off-label prescribing in primary care in different countries are 3-67%. The aim of the study was to determine the intensity of this type of prescription in anti-asthmatic agents in a recent period of time, in Castilla y León. Methods: the requirements for the therapeutic subgroup R03 (anti-asthmatic agents) prescribed in children less than 14 years of age in the Castilla-León health service from 2005 to 2010 were analyzed. Information on off-label prescribing is shown in number of anti-asthmatic prescriptions consumed at doses and/or at ages not recommended in its technical specifications. Results: a total of 394 876 prescriptions for anti-asthmatic agents were performed to an exposed population of 1 580 229 person-years. Children under four years received the highest levels of anti-asthmatic agents. The maximum prescription of bronchodilators occurred in children under 2 years, and of montelukast and single inhaled corticosteroids at one year of age. 46% of prescriptions of systemic salbutamol and 15.9% of maintenance therapy prescriptions were made in an off-label manner. Conclusions: the study shows an important and very early use of anti-asthmatic agents at ages where it is difficult to make a diagnosis of asthma and also a remarkable consumption of controller therapy at not authorized dose and/or ages. Off-label prescription do not presuppose inappropriate prescription but it should have a real benefit to the patient and be supported by scientific guarantees to justify its use (AU)

Opiniones y expectativas de los padres respecto a las infecciones respiratorias agudas de lactantes y pre-escolares. Influencia en la disposición a consultar / Opinions and expectations of the parents regarding acute respiratory infections of infants and pre-school children. Influence on the facility to consult

Objetivos: Describir las opiniones y expectativas de los padres relacionadas con la disposición a consultar por infecciones respiratorias agudas de lactantes y pre-escolares. Métodos: Estudio transversal con muestra oportunista de padres de niños menores de cinco años. Se diseñó un cuestionario que exploraba las opiniones acerca de la frecuencia, sintomatología, gravedad y tratamiento de las infecciones respiratorias agudas, así como las expectativas respecto a la atención médica por esas enfermedades, y la disposición de los padres a consultar con el médico en distintas situaciones. Se realizó un análisis multivariante exploratorio para identificar las variables más relacionadas con la disposición a consultar. Resultados: Se recogieron 317 encuestas. El 54,6% de los niños del estudio eran varones, la edad mediana (amplitud intercuartil) era de 2,0 (0,6-3,3 años) y un 5,7% había estado alguna vez hospitalizado por enfermedades respiratorias. El modelo multivariante encontró siete variables asociadas a la disposición a consultar, agrupables en tres dominios: 1) percepción de vulnerabilidad del niño (menor edad y antecedentes de hospitalización); 2) percepción de una amenaza (creencia en la gravedad de las infecciones respiratorias y expectativa de que el médico le indique si es grave); y 3) percepción de eficacia del tratamiento farmacológico (creer en la eficacia de medicinas para tos y mocos, creer en la eficacia de antibióticos, y esperar una prescripción en la consulta). Conclusiones: La disposición a consultar por las infecciones respiratorias agudas de lactantes y pre-escolares se asocia a un conjunto definido de opiniones y expectativas de los padres

Aim: Describe the parents' beliefs and expectations related to the willingness to consult for acute respiratory infections in infants and preschool children. Methods: Cross-sectional study of an opportunistic sample of parents of children of less than five years. A questionnaire was designed to explore beliefs about frequency, symptoms, severity and treatment of acute respiratory infections, expectations on health care from doctors, and willingness to consult in certain circumstances. In an exploratory multivariate analysis, the main variables related to willingness to consult were identified. Results:. There were 317 questionnaires collected; 54.6 percent of children were male, their median age (interquartile range) was 2.0 years (0.6-3.3 years), and 5.7% had been hospitalized because respiratory diseases. The multivariate model found seven variables related to the willingness to consult, that could be clustered in three domains: 1) perception of vulnerability in children (lower age and previous hospitalization); 2) perception of threat (beliefs about severity of respiratory diseases and expectations that the doctor says whether the disease is severe); and 3) perception of efficacy of drugs (beliefs about efficacy of symptomatic drugs and of antibiotics, and expectations of being prescribed a drug). Conclusions:. The willingness to consult for acute respiratory infections in infants and preschool children is related to a definite set parents' beliefs and expectations

Anti-asthmatic prescription variability in children according to age

INTRODUCTION: There is little research in the Spanish paediatric population about the consumption of anti-asthmatic agents. The aim of this study was to describe the current pattern of anti-asthmatic drug prescription in the paediatric population from a region of Spain, using the prescribed daily dose as a unit of measurement. METHODS: We analysed the requirements of R03 therapeutic subgroup (anti-asthmatic agents) in children less than 14 years of age in the Public Health System of Castilla y León from 2005 to 2010. Consumption data are presented in prescribed daily doses per thousand inhabitants per day (PDHD) and compared with defined daily doses per thousand inhabitants per day (DHD). RESULTS: 394 876 prescriptions of anti-asthmatics were given to a population of 1 580 229 persons/year. Bronchodilators, leukotriene receptor antagonists, single inhaled corticosteroids (ICS) and long-acting β2-adrenergics associated with inhaled corticosteroids were the most commonly prescribed drugs: 7.5, 5.2, 4.9 and 2.2 PDHD, respectively. The maximum prescription of bronchodilators (15.9 PDHD/9.8 DHD) occurred in children under 12 months, with montelukast (8.9 PDHD/3.6 DHD) and single inhaled corticosteroids (7.9 PDHD/2.9 DHD) at one year of age. CONCLUSIONS: Between 2005 and 2010, children under four years received a high prescription of anti-asthmatic drugs. The use of maintenance therapy was poorly aligned with the recommendations of asthma guidelines. The PDHD was more accurate for measuring consumption than DHD, especially in younger children

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Mochilas escolares y dolor de espalda en la población infantil / School backpacks and back pain in child population

Introducción: el peso de las mochilas preocupa por el esfuerzo físico que realizan los niños y su relación con problemas de espalda. El objetivo es conocer los hábitos del uso de mochilas y su relación con el dolor de espalda en población escolar. Material y métodos: estudio observacional en 4 consultas pediátricas. Se analizan variables demográficas, antropométricas y se administra un cuestionario. Resultados: son 159 niños, 80 varones y 79 mujeres, de 11 y 14 años, que cursan 5º de Educación Primaria (EP) y 2º de Educación Secundaria (ESO). El 69% acude al colegio andando, el 80% lleva la mochila en ambos hombros, el 59% se cansa y el 62,3% refiere dolor de espalda. La puntuación del dolor es 5 (escala 0-10). La mochila pesa 6,3 ± 2 kg. El peso relativo (porcentaje de peso en relación al peso del niño) es 13,4% ± 5,5 y no difiere entre sexos, medio urbano o rural, pero sí entre grupos de edad (15,5% en EP, 11,6% en ESO, p < 0,001) y centro (público: 14,3%; concertado: 12,3%; p = 0,02). No encontramos diferencias en el peso con o sin dolor (13,8% versus 12,7%; p = 0,19) ni en la presencia de dolor por sexo o edad. No se encuentra asociación entre dolor y horas de tele/ videojuegos pero sí entre dolor y horas de deporte extraescolar (más horas, menos dolor: OR [odds ratio]: 0,23; IC [intervalo de confianza] 95%: 0,08-0,7). Existe diferencia en la puntuación de síntomas psicosomáticos, mayor en los que sufren dolor (OR 1,37; IC 95%: 1,2-1,6). Conclusiones: el peso de las mochilas es el 13,4% ± 5,5 del peso del niño. Aunque no encontramos asociación entre dolor y peso, este influye en la sensación de malestar en la infancia y debe considerarse un problema de salud(AU)

[Differentiation of Yersinia enterocolitica 0:3 and 0:9 by precipitation of CaCO3 at 37 degrees C]. / Différenciation de Yersinia enterocolitica 0:3 et 0:9 par la précipitation à 37 degr'es C du CaCO3.

Precipitation of CaCO3 by different Yersinia strains on B-4 agar at 25 and 37 degrees C was studied. The 185 Yersinia strains examined produced crystals at 25 degrees C, but only 121 strains produced crystal at 37 degrees C. Strains of serotype 0:9 produced crystals at 37 degrees C, whereas strains of serotype 0:3 failed to do so. The calcium carbonate precipitation test at 37 degrees C should enable a differentiation between the two serotypes incriminated in human pathology in Europe.

Formation of bobierrite (magnesium phosphate) crystal aggregates by bacteria from human urine and renal calculi.

The formation of extracellular crystal aggregates of bobierrite [Mg3(PO4)2.8H2O] by bacteria isolated from renal calculi and urine of urolithiasic patients is found with the use of B-17 and B-43 media. The crystal aggregates were observed in the colonies as deposits of brown-yellow coloration, and were identified by X-ray powder diffraction, chemical analysis and scanning electron microscopy. The production of bobierrite by bacteria from human urine and renal calculi implies further versatility of crystal formation by microorganisms, and it may be interesting to investigate the possible relationships between calculi precipitation and urinary infection.

Precipitation of struvite in urine medium by urease-positive and urease-negative Yersinia strains.

Yersinia strains either urease-positive or urease-negative were examined for precipitation of struvite in human urine at 25 and 37 degrees C. All urease-positive strains and 8 out of 10 urease-negative strains showed the ability to produce these crystals. Incubation time required for precipitation was longer for urease-negative strains and quantity of struvite formed was higher in urease-positive ones. Regarding incubation temperature, no significant influence has been observed.

Prescripción de fármacos anticatarrales de uso sistémico a niños de 0-13 años. Un problema no resuelto / Prescription of systemic cold and cough drugs to children 0-13 years old. An unresolved problem

Introducción y objetivos: La infección de las vías respiratorias superiores es el motivo de consulta pediátrica más frecuente, generando un elevado volumen de prescripción de fármacos con desfavorable relación riesgo-beneficio. El objetivo del estudio es describir la prescripción de anticatarrales por vía sistémica a menores de 14 años en Castilla y León y analizar su variabilidad. Población y métodos: Se contabilizaron las prescripciones de los subgrupos R05 (antitusivos y mucolíticos) y R01B (simpaticomiméticos) realizadas a menores de 14 años en el sistema público de salud entre 2005-2010. Se analizaron las prescripciones como tasas crudas y ajustadas por edad, y se realizó un análisis multivariante (regresión de Poisson) de la variabilidad relacionada con el área sanitaria, el ámbito urbano/rural, la edad y el año de prescripción. Resultados: Hubo 806.785 prescripciones de anticatarrales sistémicos realizadas a una población expuesta de 1.580.229 personas-año. Las tasas de prescripción (por 100 personas-año) fueron de 20,7 (antitusivos), 7,0 (simpaticomiméticos) y 23,4 (mucolíticos). Las tasas eran mayores en los niños menores de 4 años. La prescripción máxima de mucolíticos y simpaticomiméticos ocurrió a la edad de 1 año (tasas de 41,9 y 18,7) y la de antitusivos a los 3 años (35,7). El análisis multivariante demostró una mayor prescripción en el medio rural y diferencias notables entre áreas. El número de prescripciones disminuyó entre 2005 y 2010, pero no hubo una tendencia estable en esa reducción. Conclusiones: Entre 2005 y 2010 la prescripción de anticatarrales sistémicos fue alta, alejada de las recomendaciones internacionales de tratamiento y con una marcada variabilidad geográfica(AU)

Introduction and objectives: Upper respiratory tract infections are the most common cause of paediatric consultation, generating a high volume of prescriptions of drugs with unfavourable risk-benefit ratio. The aim of this study is to describe the prescription of systemic cough and cold medicines to children under 14 years of age in Castilla y León and analyse its variability. Population and methods: A count was made of the prescriptions for the R05 therapeutic subgroup (antitussives and mucolytics) and the R01B pharmacological therapeutic subgroup (nasal decongestants for systemic use), prescribed for children under the age of 14 in the Public Health System between 2005-2010. The number of prescriptions was analysed as crude and age-adjusted rates, as well as a a multivariate analysis (Poisson regression) of the variability associated with health area, the urban/rural environment, age, and year of prescription. Results: There were 806,785 prescriptions for systemic cough and cold drugs given to an exposed population of 1,580,229 person-years. Prescription rates (per 100 person-years) were 20.7 (antitussives), 7.0 (sympathomimetic) and 23.4 (mucolytics). These drugs were employed more often in children <4 years. The prescription of mucolytics and sympathomimetics was highest at age of 1 year (rates=41.9 and 18.7, respectively) and of antitussives at 3 years (35.7). Multivariate analysis showed that in rural areas the prescription was higher than in urban areas, and that there were also significant differences between health areas. Conclusions: Between 2005 and 2010 there was a high prescription of systemic cough and cold medicines, especially in children under 2 years old, and often outside the recommended conditions of use, and there was a high geographic variabilty(AU)