Detalhe da pesquisa
1.
Evaluation of the drug disposition of RO7049389 with in vitro data and human mass balance supported by physiologically based pharmacokinetic modelling.
Br J Clin Pharmacol
; 89(10): 3079-3091, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37264516
2.
Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor.
Birth Defects Res B Dev Reprod Toxicol
; 107(3): 148-56, 2016 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27221585
3.
Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
J Pharmacol Exp Ther
; 353(1): 213-33, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25665805
4.
Translating pharmacology models effectively to predict therapeutic benefit.
Drug Discov Today
; 27(6): 1604-1621, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35304340
5.
BET Inhibition Enhances TNF-Mediated Antitumor Immunity.
Cancer Immunol Res
; 10(1): 87-107, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34782346
6.
Bioavailability and pharmacokinetic profile of balovaptan, a selective, brain-penetrant vasopressin 1a receptor antagonist, in healthy volunteers.
Expert Opin Investig Drugs
; 30(8): 893-901, 2021 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-34176392
7.
How Semiphysiological Population Pharmacokinetic Modeling Incorporating Active Hepatic Uptake Supports Phase II Dose Selection of RO7049389, A Novel Anti-Hepatitis B Virus Drug.
Clin Pharmacol Ther
; 109(4): 1081-1091, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33523474
8.
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Bioorg Med Chem Lett
; 20(2): 594-9, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19969452
9.
Pharmacokinetics and metabolism of the dipeptidyl peptidase IV inhibitor carmegliptin in rats, dogs, and monkeys.
Xenobiotica
; 40(12): 840-52, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-20868265
10.
Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein.
Neuro Oncol
; 22(6): 819-829, 2020 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32383735
11.
Metabolism, excretion, and pharmacokinetics of [14c]-radiolabeled aleglitazar: a phase I, nonrandomized, open-label, single-center, single-dose study in healthy male volunteers.
Clin Ther
; 34(2): 420-9, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22244809
12.
Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.
Drug Metab Lett
; 4(2): 77-87, 2010 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20446913
13.
Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.
Toxicol Lett
; 190(3): 310-6, 2009 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-19695316
14.
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.
Carcinogenesis
; 23(1): 115-22, 2002 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-11756232
15.
Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometry.
Chem Res Toxicol
; 15(4): 551-61, 2002 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-11952342