Detalhe da pesquisa
1.
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection.
N Engl J Med
; 387(21): 1957-1968, 2022 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36346079
2.
Comparison of Pharmacokinetics of the GalNAc-Conjugated Antisense Oligonucleotide GSK3389404 in Participants with Chronic Hepatitis B Infection across the Asia-Pacific Region.
Antimicrob Agents Chemother
; 67(1): e0090022, 2023 01 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36507675
3.
Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy.
J Hepatol
; 77(4): 967-977, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35714812
4.
Safety, Tolerability, Pharmacokinetics, and Acceptability of Oral and Long-Acting Cabotegravir in HIV-Negative Chinese Men.
Antimicrob Agents Chemother
; 66(3): e0205721, 2022 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35129374
5.
China-United States Research Collaborations in Antimicrobial Resistance.
Clin Infect Dis
; 67(suppl_2): S142-S145, 2018 11 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30423056
6.
B-Clear Phase 2b Study Design: Establishing the Efficacy and Safety of Bepirovirsen in Patients with Chronic Hepatitis B Virus Infection.
Adv Ther
; 40(9): 4101-4110, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37393402
7.
Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus-Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses.
Clin Pharmacol Drug Dev
; 11(10): 1191-1202, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35971951
8.
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Nat Med
; 27(10): 1725-1734, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34642494
9.
A Randomized, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects.
Clin Pharmacol Drug Dev
; 8(6): 790-801, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30861337