RESUMO
Testing for viral BKV-DNA in urine is a non-invasive early detection and monitoring tool in the diagnostic of BKV-related pathologies: quantitative analysis by Real-Time PCR can provide useful information in addition to cytologic analysis, although our study suggests that high BKV viruria is not necessarily associated with kidney or bladder damage.
Assuntos
Vírus BK/isolamento & purificação , DNA Viral/urina , Hospedeiro Imunocomprometido , Nefropatias/diagnóstico , Infecções por Polyomavirus/diagnóstico , Infecções Tumorais por Vírus/diagnóstico , Adolescente , Adulto , Idoso , Vírus BK/fisiologia , Criança , Pré-Escolar , Diagnóstico Precoce , Feminino , Humanos , Lactente , Nefropatias/virologia , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Sensibilidade e Especificidade , Infecções Tumorais por Vírus/virologia , Ativação ViralRESUMO
A rare case of brain abscess due to Gemella morbillorum, a normal inhabitant of the oral cavity, is presented. The aim of this report is to draw the attention of radiology literature readers to this little known pathogen, which caused a potentially life-threatening condition in an immunocompetent young man, and to emphasise the usefulness of a combined stereotactic, medical, and imaging approach to deep-located brain abscesses.
Assuntos
Abscesso Encefálico/microbiologia , Abscesso Encefálico/terapia , Staphylococcaceae/isolamento & purificação , Adulto , Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico , Antibacterianos/uso terapêutico , Abscesso Encefálico/diagnóstico por imagem , Clindamicina/uso terapêutico , Terapia Combinada , Humanos , Masculino , Staphylococcaceae/efeitos dos fármacos , Técnicas Estereotáxicas , Tomografia Computadorizada por Raios XRESUMO
The efficacy of two polymyxin-like peptides, KFFKFFKFF and IKFLKFLKFL, alone and combined with levofloxacin, was investigated in a rat model of septic shock. Rats were given an ip injection of 2 x 10(10) cfu of Escherichia coli and randomized to receive ip isotonic sodium chloride solution, 7 mg/kg levofloxacin, 1 mg/kg polymyxin B and 1 mg/kg of each polymyxin-like peptides alone or combined with 7 mg/kg levofloxacin. Polymyxins achieved a significant reduction in plasma endotoxin and tumour necrosis factor alpha (TNF-alpha) concentration. Levofloxacin significantly reduced the bacterial growth and TNF-alpha concentration. The combinations of polymyxin-like peptides and levofloxacin demonstrated the highest efficacy.