Detalhe da pesquisa
1.
GPCR-G Protein-ß-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Cell
; 166(4): 907-919, 2016 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27499021
2.
Mechanism of intracellular allosteric ß2AR antagonist revealed by X-ray crystal structure.
Nature
; 548(7668): 480-484, 2017 08 24.
Artigo
Inglês
| MEDLINE | ID: mdl-28813418
3.
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Nature
; 535(7612): 448-52, 2016 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27409812
4.
ß-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated ß Adrenergic Receptor Cardioprotection.
Mol Pharmacol
; 100(6): 568-579, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34561298
5.
Unique Positive Cooperativity Between the ß-Arrestin-Biased ß-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the ß2-Adrenergic Receptor.
Mol Pharmacol
; 100(5): 513-525, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34580163
6.
Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
J Biol Chem
; 295(49): 16773-16784, 2020 12 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32978252
7.
Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in ß-arrestin coupling.
Proc Natl Acad Sci U S A
; 115(15): 3834-3839, 2018 04 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29581292
8.
Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
Proc Natl Acad Sci U S A
; 114(7): 1708-1713, 2017 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28130548
9.
Small-Molecule Positive Allosteric Modulators of the ß2-Adrenoceptor Isolated from DNA-Encoded Libraries.
Mol Pharmacol
; 94(2): 850-861, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29769246
10.
Conformationally selective RNA aptamers allosterically modulate the ß2-adrenoceptor.
Nat Chem Biol
; 12(9): 709-16, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27398998
11.
Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function.
Adv Exp Med Biol
; 993: 535-556, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28900932
12.
Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1.
J Cell Sci
; 126(Pt 2): 667-75, 2013 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23203809
13.
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
bioRxiv
; 2024 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38586060
14.
Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.
Proc Natl Acad Sci U S A
; 106(47): 20087-92, 2009 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19897728
15.
Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.
Mol Biol Cell
; 17(10): 4446-58, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16899508
16.
Mechanism of ß2AR regulation by an intracellular positive allosteric modulator.
Science
; 364(6447): 1283-1287, 2019 06 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31249059
17.
G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the ß2-adrenergic receptor.
Sci Signal
; 11(544)2018 08 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30131371
18.
How carvedilol does not activate ß2-adrenoceptors.
Nat Commun
; 14(1): 7866, 2023 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38036531
19.
Manifold roles of ß-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
Sci Signal
; 11(549)2018 09 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30254056
20.
Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity.
PLoS One
; 9(7): e101023, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25013939