Detalhe da pesquisa
1.
Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase.
Bioorg Med Chem Lett
; 24(19): 4689-4693, 2014 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25193234
2.
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality.
ACS Infect Dis
; 10(3): 928-937, 2024 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38334357
3.
Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality.
bioRxiv
; 2023 Sep 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37781587
4.
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State.
ACS Chem Biol
; 17(9): 2507-2518, 2022 09 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36038138
5.
Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun
; 12(1): 6285, 2021 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34725358
6.
Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase.
Antibiotics (Basel)
; 9(4)2020 Apr 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32268615
7.
Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.
ACS Chem Biol
; 14(9): 1990-1997, 2019 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31407891
8.
Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis
; 4(2): 175-184, 2018 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29131575
9.
Biotin Protein Ligase Is a Target for New Antibacterials.
Antibiotics (Basel)
; 5(3)2016 Jul 25.
Artigo
Inglês
| MEDLINE | ID: mdl-27463729
10.
New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase.
ACS Med Chem Lett
; 7(12): 1068-1072, 2016 Dec 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27994739
11.
Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.
ACS Med Chem Lett
; 6(2): 216-20, 2015 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25699152
12.
Structure guided design of biotin protein ligase inhibitors for antibiotic discovery.
Curr Top Med Chem
; 14(1): 4-20, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24236729