Acute hemodynamics of cardiac sympathetic denervation.

INTRODUCTION: We aimed to study the immediate hemodynamic effects of thoracoscopic bilateral cardiac sympathetic denervation (CSD) for recurrent ventricular tachycardia (VT) or VT storm. METHOD: We studied a group of 18 adults who underwent bilateral thoracoscopic CSD; the blood pressure (BP) and Heart Rate (HR) were continuously monitored during the surgery and up to 6 h post-operatively. RESULTS: Immediately on removal of the sympathetic ganglia, the patients had a drop in both the systolic (110 mm Hg to 95.8 mm Hg, p < 0.001) and diastolic BP (69.4 mm Hg to65 mm Hg, p = 0.007) along with a drop in the HR (81.6 bpm to 61.2 bpm, p < 0.001).At 6 h after CSD, the systolic and diastolic BP did not recover significantly, while there was recovery in HR (61.2 bpm to 66 bpm, p = 0.02). There was no significant difference between those with and without left ventricular (LV) systolic dysfunction. CONCLUSION: The acute hemodynamic changes during the perioperative period of CSD are significant but not serious. Awareness of this is useful for peri-operative management.

Semen quality of industrial workers occupationally exposed to chromium.

A total of sixty-one subjects occupationally exposed to chromium in an industry which manufactures chromium sulphate and fifteen control subjects from a nearby industry which does not manufacture any chromium related compounds were studied. The history of each subject was recorded on pre-designed form through interview and a routine medical examination was carried out. Blood samples (5-6 ml) were collected for the estimation of chromium and semen samples were collected for semen analysis and the determination of copper and zinc levels in the seminal plasma. Clinical examination revealed nasal perforation in 10 subjects (out of 61) in the exposed group as compared to none in the control group. A significantly higher level of chromium was observed in the blood of the exposed workers as compared to the control. The concentration of zinc in seminal plasma was lower while the level of copper was higher in the exposed group as compared to the control. However, these changes were not statistically significant. Statistically significant higher numbers of morphologically abnormal sperms were noticed in the exposed group with respect to the control. Further analysis of the data indicated that about 53% of the exposed subjects showed less than 30% normal forms as compared to 10% in control subjects. However, no significant alterations in semen volume, liquefaction time, mean pH value, sperm viability, concentration or motility, were noticed between chromium exposed and unexposed workers. The data also indicates that exposure to chromium has some effect on human sperm as a significant positive correlation (r=0.301) was observed between percentages of abnormal sperm morphology and blood chromium levels (p=0.016) after pooling all the data of the control and exposure groups.

Effects of industrial pollution on respiratory morbidity among female residents of India.

The authors evaluated the respiratory symptoms and pulmonary function test results (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1], and ratio of FEV1 to FVC [FEV1%]) of female residents of the critically polluted industrial estate of Vapi, Gujarat (state), India, and compared these with control information derived from a village 20 km away. The authors categorized the studied residents as living in Vapi, in town, or in villages proximal to the Gujarat Industrial Development Corporation; living 2 to 3 km away from Vapi; living 3 to 5 km away from Vapi; and being in the control group. The authors found no significant association between respiratory symptoms and pulmonary function among Vapi residents. However, the obstructive type of abnormality was most predominant and significantly different among Vapi residents. The restrictive type was highly prevalent among residents living 2 to 3 km away from Vapi compared with the control group. These results suggest significant respiratory morbidity among residents that was associated with age and distance from the development corporation.